Gonzalo de Prat Gay

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Lucia Beatriz ChemesInvestigadora Independiente, CONICET, ArgentinaVerified email at iib.unsam.edu.ar
Ignacio Enrique SanchezCONICET researcher, Universidad de Buenos Aires (Argentina)Verified email at qb.fcen.uba.ar
Alan FershtEmeritus Group Leader, MRC Laboratory of Molecular Biology, University of CambridgeVerified email at cam.ac.uk
Alejandro Daniel NadraUBA - CONICETVerified email at qi.fcen.uba.ar
Diego U. FerreiroCONICET, FCEyN, Universidad de Buenos AiresVerified email at qb.fcen.uba.ar
Mariano DellaroleCIBION, CONICET (Argentina)Verified email at cibion.conicet.gov.ar
Mok YKAssociate Professor of Biological Sciences, National University of SingaporeVerified email at nus.edu.sg
Andreas LadurnerChair of Physiological Chemistry, LMU Munich; Founder, Managing Director and CSO, Eisbach Bio GmbHVerified email at med.lmu.de
Juliana GlavinaPost-Doctoral. FONCyT, ArgentinaVerified email at iib.unsam.edu.ar
Fabio Ceneviva Lacerda de AlmeidaProfessor of Biochemistry, Federal University of Rio de JaneiroVerified email at bioqmed.ufrj.br
Jerson L. SilvaProfessor of Biochemistry, Universidade Federal do Rio de JaneiroVerified email at bioqmed.ufrj.br
Luis Mauricio T R LimaProfessor of Structural Biology, Federal University of Rio de Janeiro - UFRJ - BrazilVerified email at UFRJ.BR
Laura MorelliCONICETVerified email at leloir.org.ar
Cristina Marino BusljeResearcher, Nat. Research Council (CONICET). Head of the Bioinformatics Unit.Fundación InstitutoVerified email at leloir.org.ar
Alison McBridenational institutes of healthVerified email at nih.gov
Guilherme A. P. de OliveiraAssociate Professor, Medical Biochemistry Institute Leopoldo de Meis, National Institute ofVerified email at bioqmed.ufrj.br
Ashley BuckleReplayVerified email at replay.bio
Debora FoguelProfessor Titular, Universidade Federal do Rio de JaneiroVerified email at bioqmed.ufrj.br
Gastón ParisCentro de Investigaciones en BionanocienciasVerified email at cibion.conicet.gov.ar
Andrés G. SalvayPh.D., Professor of Physics, Universidad Nacional de Quilmes, ArgentinaVerified email at unq.edu.ar

Gonzalo de Prat Gay

Head, Protein Structure-Function and Engineering Lab, Fundación Instituto Leloir-CONICET, Argentina

Verified email at leloir.org.ar

Virus biomolecular condensates intrinsically disordered proteins protein folding assembly and interactions


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UDP-Glc: glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten globule-like folding intermediates JJ Caramelo, OA Castro, LG Alonso, G de Prat-Gay, AJ Parodi Proceedings of the National Academy of Sciences 100 (1), 86-91, 2003	221	2003
The endoplasmic reticulum glucosyltransferase recognizes nearly native glycoprotein folding intermediates JJ Caramelo, OA Castro, G de Prat-Gay, AJ Parodi Journal of Biological Chemistry 279 (44), 46280-46285, 2004	165	2004
Circular dichroism techniques for the analysis of intrinsically disordered proteins and domains LB Chemes, LG Alonso, MG Noval, G de Prat-Gay Intrinsically disordered protein analysis: Volume 1, methods and …, 2012	125	2012
Equilibrium dissociation and unfolding of the dimeric human papillomavirus strain‐16 E2 DNA‐binding domain YK Mok, M Bycroft, GDP Gay, P Jonathan Butler Protein science 5 (2), 310-319, 1996	120	1996
Molecular basis for phosphorylation-dependent, PEST-mediated protein turnover MM García-Alai, M Gallo, M Salame, DE Wetzler, AA McBride, M Paci, ... Structure 14 (2), 309-319, 2006	111	2006
High-risk (HPV16) human papillomavirus E7 oncoprotein is highly stable and extended, with conformational transitions that could explain its multiple cellular binding partners LG Alonso, MM García-Alai, AD Nadra, AN Lapeña, FL Almeida, ... Biochemistry 41 (33), 10510-10518, 2002	94	2002
Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2 LS Itzhaki, JL Neira, J Ruiz-Sanz, G de Prat Gay, AR Fersht Journal of molecular biology 254 (2), 289-304, 1995	87	1995
The N-terminal module of HPV16 E7 is an intrinsically disordered domain that confers conformational and recognition plasticity to the oncoprotein MM García-Alai, LG Alonso, G de Prat-Gay Biochemistry 46 (37), 10405-10412, 2007	85	2007
Conformational buffering underlies functional selection in intrinsically disordered protein regions NS Gonzalez-Foutel, J Glavina, WM Borcherds, M Safranchik, ... Nature structural & molecular biology 29 (8), 781-790, 2022	82	2022
The HPV16 E7 viral oncoprotein self-assembles into defined spherical oligomers LG Alonso, MM García-Alai, C Smal, JM Centeno, R Iacono, E Castano, ... Biochemistry 43 (12), 3310-3317, 2004	80	2004
Casein Kinase II phosphorylation-induced conformational switch triggers degradation of the papillomavirus E2 protein KJ Penrose, M Garcia-Alai, G de Prat-Gay, AA McBride Journal of Biological Chemistry 279 (21), 22430-22439, 2004	76	2004
Conformational pathway of the polypeptide chain of chymotrypsin inhibitor-2 growing from its N terminusin vitro. Parallels with the protein folding pathway G de Prat Gay, J Ruiz-Sanz, JL Neira, FJ Corrales, DE Otzen, ... Journal of molecular biology 254 (5), 968-979, 1995	76	1995
Generation of a family of protein fragments for structure-folding studies. 1. Folding complementation of two fragments of chymotrypsin inhibitor-2 formed by cleavage at its … G de Prat Gay, AR Fersht Biochemistry 33 (25), 7957-7963, 1994	74	1994
Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module. G de Prat Gay, J Ruiz-Sanz, JL Neira, LS Itzhaki, AR Fersht Proceedings of the National Academy of Sciences 92 (9), 3683-3686, 1995	71	1995
Folding of a pressure-denatured model protein R Mohana-Borges, JL Silva, J Ruiz-Sanz, G de Prat-Gay Proceedings of the National Academy of Sciences 96 (14), 7888-7893, 1999	66	1999
Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2 AG Ladurner, LS Itzhaki, G de Prat Gay, AR Fersht Journal of molecular biology 273 (1), 317-329, 1997	66	1997
Deconstructing virus condensation N Lopez, G Camporeale, M Salgueiro, SS Borkosky, A Visentín, ... PLoS pathogens 17 (10), e1009926, 2021	65	2021
Towards the complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two … JL Neira, B Davis, AG Ladurner, AM Buckle, G de Prat Gay, AR Fersht Folding and Design 1 (3), 189-208, 1996	64	1996
Convergent evolution and mimicry of protein linear motifs in host–pathogen interactions LB Chemes, G de Prat-Gay, IE Sánchez Current opinion in structural biology 32, 91-101, 2015	60	2015
Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein: Structural modularity, intrinsic disorder and phosphorylation of human … LB Chemes, IE Sanchez, C Smal, G de Prat‐Gay The FEBS journal 277 (4), 973-988, 2010	60	2010

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