| A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission VRJ Clarke, BA Ballyk, KH Hoo, A Mandelzys, A Pellizzari, CP Bath, ... Nature 389 (6651), 599-603, 1997 | 478 | 1997 |
| Kainate receptors are involved in synaptic plasticity ZA Bortolotto, VRJ Clarke, CM Delany, MC Parry, I Smolders, M Vignes, ... Nature 402 (6759), 297-301, 1999 | 416 | 1999 |
| LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors AE Kingston, PL Ornstein, RA Wright, BG Johnson, NG Mayne, JP Burnett, ... Neuropharmacology 37 (1), 1-12, 1998 | 399 | 1998 |
| A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP SE Lauri, ZA Bortolotto, D Bleakman, PL Ornstein, D Lodge, JTR Isaac, ... Neuron 32 (4), 697-709, 2001 | 252 | 2001 |
| A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus SE Lauri, ZA Bortolotto, R Nistico, D Bleakman, PL Ornstein, D Lodge, ... Neuron 39 (2), 327-341, 2003 | 233 | 2003 |
| Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat RMA Simmons, DL Li, KH Hoo, M Deverill, PL Ornstein, S Iyengar Neuropharmacology 37 (1), 25-36, 1998 | 209 | 1998 |
| LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine CN Sang, NM Ramadan, RG Wallihan, AS Chappell, FG Freitag, ... Cephalalgia 24 (7), 596-602, 2004 | 196 | 2004 |
| Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures I Smolders, ZA Bortolotto, VRJ Clarke, R Warre, GM Khan, MJ O'neill, ... Nature neuroscience 5 (8), 796-804, 2002 | 183 | 2002 |
| Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy) methyl]-benzimidazoles as selective neuropeptide Y Y1 receptor antagonists H Zarrinmayeh, AM Nunes, PL Ornstein, DM Zimmerman, MB Arnold, ... Journal of Medicinal Chemistry 41 (15), 2709-2719, 1998 | 182 | 1998 |
| The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus M Vignes, VRJ Clarke, MJ Parry, D Bleakman, D Lodge, PL Ornstein, ... Neuropharmacology 37 (10-11), 1269-1277, 1998 | 180 | 1998 |
| The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity SM Fitzjohn, ZA Bortolotto, MJ Palmer, AJ Doherty, PL Ornstein, ... Neuropharmacology 37 (12), 1445-1458, 1998 | 176 | 1998 |
| NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal K Rasmussen, RW Fuller, ME Stockton, KW Perry, RM Swinford, ... European journal of pharmacology 197 (1-2), 9-16, 1991 | 174 | 1991 |
| Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia MJ O'Neill, A Bond, PL Ornstein, MA Ward, CA Hicks, K Hoo, D Bleakman, ... Neuropharmacology 37 (10-11), 1211-1222, 1998 | 141 | 1998 |
| Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S, 4aR, 6R, 8aR)-6-[2-(1 (2) H-tetrazole-5-yl) ethyl] decahyd roisdoquinoline-3 carboxylic-acid. R Bleakman, DD Schoepp, B Ballyk, H Bufton, EF Sharpe, K Thomas, ... Molecular Pharmacology 49 (4), 581-585, 1996 | 138 | 1996 |
| N-Methyl-d-aspartic acid-induced lethality in mice: selective antagonism by phencylidine-like drugs JD Leander, RR Lawson, PL Ornstein, DM Zimmerman Brain research 448 (1), 115-120, 1988 | 138 | 1988 |
| (3SR, 4aRS, 6RS, 8aRS)-6-[2-(1H-Tetrazol-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist PL Ornstein, MB Arnold, NK Augenstein, D Lodge, JD Leander, ... Journal of medicinal chemistry 36 (14), 2046-2048, 1993 | 135 | 1993 |
| Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists H Zarrinmayeh, DM Zimmerman, BE Cantrell, DA Schober, RE Bruns, ... Bioorganic & medicinal chemistry letters 9 (5), 647-652, 1999 | 131 | 1999 |
| 2-Substituted (2 SR)-2-amino-2-((1 SR, 2 SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of … PL Ornstein, TJ Bleisch, MB Arnold, JH Kennedy, RA Wright, BG Johnson, ... Journal of medicinal chemistry 41 (3), 358-378, 1998 | 122 | 1998 |
| A new method for the efficient conversion of alcohols into iodides via treatment with trimethylsilyl iodide ME Jung, PL Ornstein Tetrahedron Letters 18 (31), 2659-2662, 1977 | 119 | 1977 |
| An improved synthesis of homoproline and derivatives RT Shuman, PL Ornstein, JW Paschal, PD Gesellchen The Journal of Organic Chemistry 55 (2), 738-741, 1990 | 117 | 1990 |
graham collingridgeTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Lunenfeld-TanenbaumVerified email at bris.ac.uk