| APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 275 | 2020 |
| APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes J Zhao, MD Davis, YA Martens, M Shinohara, NR Graff-Radford, ... Human molecular genetics 26 (14), 2690-2700, 2017 | 221 | 2017 |
| Powerful beneficial effects of benfotiamine on cognitive impairment and β-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice X Pan, N Gong, J Zhao, Z Yu, F Gu, J Chen, X Sun, L Zhao, M Yu, Z Xu, ... Brain 133 (5), 1342-1351, 2010 | 161 | 2010 |
| A review on research progress of transketolase J Zhao, CJ Zhong Neuroscience bulletin 25 (2), 94, 2009 | 112 | 2009 |
| Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, ... Nature neuroscience 25 (8), 1020-1033, 2022 | 109 | 2022 |
| Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells MC Wren, J Zhao, CC Liu, ME Murray, Y Atagi, MD Davis, Y Fu, HJ Okano, ... Molecular neurodegeneration 10, 1-13, 2015 | 95 | 2015 |
| Modeling neurodegenerative microenvironment using cortical organoids derived from human stem cells Y Yan, L Song, J Bejoy, J Zhao, T Kanekiyo, G Bu, Y Zhou, Y Li Tissue Engineering Part A 24 (13-14), 1125-1137, 2018 | 81 | 2018 |
| Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway J Zhao, Y Fu, CC Liu, M Shinohara, HM Nielsen, Q Dong, T Kanekiyo, ... Journal of Biological Chemistry 289 (16), 11282-11292, 2014 | 81 | 2014 |
| Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan Y Fu, J Zhao, Y Atagi, HM Nielsen, CC Liu, H Zheng, M Shinohara, ... Molecular neurodegeneration 11, 1-11, 2016 | 75 | 2016 |
| APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia CC Liu, ME Murray, X Li, N Zhao, N Wang, MG Heckman, F Shue, ... Science translational medicine 13 (613), eabc9375, 2021 | 72 | 2021 |
| LRP1 is a neuronal receptor for α-synuclein uptake and spread K Chen, YA Martens, A Meneses, DH Ryu, W Lu, AC Raulin, F Li, J Zhao, ... Molecular neurodegeneration 17 (1), 57, 2022 | 67 | 2022 |
| APOE2 is associated with longevity independent of Alzheimer’s disease M Shinohara, T Kanekiyo, M Tachibana, A Kurti, M Shinohara, Y Fu, ... Elife 9, e62199, 2020 | 64 | 2020 |
| Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease CC Liu, N Wang, Y Chen, Y Inoue, F Shue, Y Ren, M Wang, W Qiao, ... Nature immunology 24 (11), 1854-1866, 2023 | 57 | 2023 |
| Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency Y Zhao, X Pan, J Zhao, Y Wang, Y Peng, C Zhong Journal of neurochemistry 111 (2), 537-546, 2009 | 54 | 2009 |
| Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease CC Liu, Y Yamazaki, MG Heckman, YA Martens, L Jia, A Yamazaki, ... Alzheimer's & Dementia 16 (10), 1372-1383, 2020 | 51 | 2020 |
| Exposure to pyrithiamine increases β-amyloid accumulation, Tau hyperphosphorylation, and glycogen synthase kinase-3 activity in the brain J Zhao, X Sun, Z Yu, X Pan, F Gu, J Chen, W Dong, L Zhao, C Zhong Neurotoxicity research 19, 575-583, 2011 | 45 | 2011 |
| APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology Y Jin, F Li, B Sonoustoun, NC Kondru, YA Martens, W Qiao, MG Heckman, ... Acta neuropathologica 143 (6), 641-662, 2022 | 41 | 2022 |
| Differential effects of extracellular vesicles of lineage-specific human pluripotent stem cells on the cellular behaviors of isogenic cortical spheroids M Marzano, J Bejoy, MR Cheerathodi, L Sun, SB York, J Zhao, ... Cells 8 (9), 993, 2019 | 35 | 2019 |
| Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids J Zhao, W Lu, Y Ren, Y Fu, YA Martens, F Shue, MD Davis, X Wang, ... Acta neuropathologica 142 (5), 807-825, 2021 | 32 | 2021 |
| Dync1h1 Mutation Causes Proprioceptive Sensory Neuron Loss and Impaired Retrograde Axonal Transport of Dorsal Root Ganglion Neurons J Zhao, Y Wang, H Xu, Y Fu, T Qian, D Bo, YX Lu, Y Xiong, J Wan, ... CNS neuroscience & therapeutics 22 (7), 593-601, 2016 | 24 | 2016 |
