Aromatic thiol-mediated cleavage of N–O bonds enables chemical ubiquitylation of folded proteins CE Weller, A Dhall, F Ding, E Linares, SD Whedon, NA Senger, EL Tyson, ... Nature Communications 7 (1), 12979, 2016 | 70 | 2016 |
Selenocysteine as a latent bioorthogonal electrophilic probe for deubiquitylating enzymes SD Whedon, N Markandeya, ASJB Rana, NA Senger, CE Weller, ... Journal of the American Chemical Society 138 (42), 13774-13777, 2016 | 40 | 2016 |
Histone H2B deacylation selectivity: exploring chromatin’s dark matter with an engineered sortase ZA Wang, SD Whedon, M Wu, S Wang, EA Brown, A Anmangandla, ... Journal of the American Chemical Society 144 (8), 3360-3364, 2022 | 39 | 2022 |
Structural basis of sirtuin 6-catalyzed nucleosome deacetylation ZA Wang, JW Markert, SD Whedon, M Yapa Abeywardana, K Lee, ... Journal of the American Chemical Society 145 (12), 6811-6822, 2023 | 35 | 2023 |
Hairpin structure stability plays a role in the activity of two antimicrobial peptides K Sivanesam, BL Kier, SD Whedon, C Chatterjee, NH Andersen FEBS letters 590 (24), 4480-4488, 2016 | 21 | 2016 |
KATs off: Biomedical insights from lysine acetyltransferase inhibitors SD Whedon, PA Cole Current opinion in chemical biology 72, 102255, 2023 | 20 | 2023 |
Distinct biochemical properties of the class I histone deacetylase complexes K Lee, SD Whedon, ZA Wang, PA Cole Current opinion in chemical biology 70, 102179, 2022 | 14 | 2022 |
Trimethylation of the R5 silica‐precipitating peptide increases silica particle size by redirecting orthosilicate binding EL Buckle, J Sampath, N Michael, SD Whedon, CJA Leonen, ... ChemBioChem 21 (22), 3208-3211, 2020 | 11 | 2020 |
Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1 K Lee, M Barone, AL Waterbury, H Jiang, E Nam, SE DuBois-Coyne, ... Nature Chemical Biology, 1-11, 2024 | 5 | 2024 |
Semisynthetic approach to the analysis of tumor suppressor PTEN ubiquitination R Iwase, DR Dempsey, SD Whedon, H Jiang, BA Palanski, B Deng, ... Journal of the American Chemical Society 145 (11), 6039-6044, 2023 | 5 | 2023 |
A MOZ-TIF2 leukemia mouse model displays KAT6-dependent H3K23 propionylation and overexpression of a set of active developmental genes AE Smolko, DW Sullivan, SN Olsen, H Kang, SD Whedon, JB Baell, ... Proceedings of the National Academy of Sciences 121 (26), e2405905121, 2024 | 3 | 2024 |
A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins SD Whedon, MK Parker, EL Tyson, T Ritterhoff, PMM Shelton, ... Chemical Communications 55 (14), 2043-2045, 2019 | 3 | 2019 |
Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity MY Abeywardana, SD Whedon, K Lee, E Nam, R Dovarganes, ... Journal of Biological Chemistry 300 (9), 107722, 2024 | 2 | 2024 |
Biological consequences of improving the structural stability of hairpins that have antimicrobial activity K Sivanesam, BL Kier, SD Whedon, C Chatterjee, NH Andersen Journal of Peptide Science 23 (12), 899-906, 2017 | 2 | 2017 |
A time-resolved Förster resonance energy transfer assay to measure activity of the deamidase of the prokaryotic ubiquitin-like protein IC Eustis, J Huang, ME Pilkerton, SD Whedon, C Chatterjee Analytical biochemistry 487, 27-29, 2015 | 1 | 2015 |
A circular engineered sortase for interrogating histone H3 in chromatin SD Whedon, K Lee, ZA Wang, E Zahn, C Lu, M Yapa Abeywardana, ... bioRxiv, 2024 | | 2024 |