Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13752* | 2021 |
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ... Cell Death & Differentiation 25 (3), 486-541, 2018 | 6302 | 2018 |
The consensus molecular subtypes of colorectal cancer J Guinney, R Dienstmann, X Wang, A De Reynies, A Schlicker, ... Nature medicine 21 (11), 1350-1356, 2015 | 5045 | 2015 |
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment L Vermeulen, F De Sousa E Melo, M Van Der Heijden, K Cameron, ... Nature cell biology 12 (5), 468-476, 2010 | 2124 | 2010 |
FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC) JP Medema, C Scaffidi, FC Kischkel, A Shevchenko, M Mann, ... The EMBO journal, 1997 | 1635 | 1997 |
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 M Todaro, MP Alea, AB Di Stefano, P Cammareri, L Vermeulen, F Iovino, ... Cell stem cell 1 (4), 389-402, 2007 | 1357 | 2007 |
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 L Galluzzi, BS Pedro, I Vitale, SA Aaronson, JM Abrams, D Adam, ... Cell Death & Differentiation 22 (1), 58-73, 2015 | 1221 | 2015 |
Sequential cancer mutations in cultured human intestinal stem cells J Drost, RH Van Jaarsveld, B Ponsioen, C Zimberlin, R Van Boxtel, ... Nature 521 (7550), 43-47, 2015 | 1141 | 2015 |
Cancer stem cells: the challenges ahead JP Medema Nature cell biology 15 (4), 338-344, 2013 | 949 | 2013 |
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity L Vermeulen, M Todaro, F de Sousa Mello, MR Sprick, K Kemper, ... Proceedings of the National Academy of Sciences 105 (36), 13427-13432, 2008 | 931 | 2008 |
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions F De Sousa E Melo, X Wang, M Jansen, E Fessler, A Trinh, ... Nature medicine 19 (5), 614-618, 2013 | 895 | 2013 |
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes L Galluzzi, SA Aaronson, J Abrams, ES Alnemri, DW Andrews, ... Cell Death & Differentiation 16 (8), 1093-1107, 2009 | 868 | 2009 |
Intra-tumor heterogeneity from a cancer stem cell perspective PR Prasetyanti, JP Medema Molecular cancer 16 (1), 41, 2017 | 764 | 2017 |
Cancer stem cell niche: the place to be T Borovski, F De Sousa E Melo, L Vermeulen, JP Medema Cancer research 71 (3), 634-639, 2011 | 670 | 2011 |
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer JP Medema, L Vermeulen Nature 474 (7351), 318-326, 2011 | 631 | 2011 |
Colon cancer stem cells: promise of targeted therapy M Todaro, MG Francipane, JP Medema, G Stassi Gastroenterology 138 (6), 2151-2162, 2010 | 569 | 2010 |
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b C Scaffidi, JP Medema, PH Krammer, ME Peter Journal of Biological Chemistry 272 (43), 26953-26958, 1997 | 497 | 1997 |
The developing cancer stem-cell model: clinical challenges and opportunities L Vermeulen, FS e Melo, DJ Richel, JP Medema The lancet oncology 13 (2), e83-e89, 2012 | 481 | 2012 |
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors JP Medema, J De Jong, LTC Peltenburg, EME Verdegaal, A Gorter, ... Proceedings of the National Academy of Sciences 98 (20), 11515-11520, 2001 | 473 | 2001 |
Cancer stem cells–old concepts, new insights L Vermeulen, MR Sprick, K Kemper, G Stassi, JP Medema Cell Death & Differentiation 15 (6), 947-958, 2008 | 468 | 2008 |