| DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation CJ Bakkenist, MB Kastan Nature 421 (6922), 499-506, 2003 | 4455 | 2003 |
| Initiating cellular stress responses CJ Bakkenist, MB Kastan Cell 118 (1), 9-17, 2004 | 618 | 2004 |
| Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway R Kitagawa, CJ Bakkenist, PJ McKinnon, MB Kastan Genes & development 18 (12), 1423-1438, 2004 | 557 | 2004 |
| The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response J Karlseder, K Hoke, OK Mirzoeva, C Bakkenist, MB Kastan, JHJ Petrini, ... PLoS biology 2 (8), e240, 2004 | 508 | 2004 |
| The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo FP Vendetti, A Lau, S Schamus, TP Conrads, MJ O'Connor, CJ Bakkenist Oncotarget 6 (42), 44289, 2015 | 274 | 2015 |
| Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress W Qian, S Choi, GA Gibson, SC Watkins, CJ Bakkenist, B Van Houten Journal of cell science 125 (23), 5745-5757, 2012 | 223 | 2012 |
| ATR kinase inhibitor AZD6738 potentiates CD8+ T cell–dependent antitumor activity following radiation FP Vendetti, P Karukonda, DA Clump, T Teo, R Lalonde, K Nugent, ... The Journal of clinical investigation 128 (9), 3926-3940, 2018 | 183 | 2018 |
| ATM activation in normal human tissues and testicular cancer J Bartkova, CJ Bakkenist, ERD Meyts, NE Skakkebæk, M Sehested, ... Cell cycle 4 (6), 838-845, 2005 | 183 | 2005 |
| Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation Z Hořejší, J Falck, CJ Bakkenist, MB Kastan, J Lukas, J Bartek Oncogene 23 (17), 3122-3127, 2004 | 171 | 2004 |
| Ionizing Radiation Induces Ataxia Telangiectasia Mutated-Dependent Checkpoint Signaling and G2 But Not G1 Cell Cycle Arrest in Pluripotent Human Embryonic … O Momčilović, S Choi, S Varum, C Bakkenist, G Schatten, C Navara Stem Cells 27 (8), 1822-1835, 2009 | 160 | 2009 |
| An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication TN Moiseeva, Y Yin, MJ Calderon, C Qian, S Schamus-Haynes, ... Proceedings of the National Academy of Sciences 116 (27), 13374-13383, 2019 | 153 | 2019 |
| Few-shot learning creates predictive models of drug response that translate from high-throughput screens to individual patients J Ma, SH Fong, Y Luo, CJ Bakkenist, JP Shen, S Mourragui, LFA Wessels, ... Nature Cancer 2 (2), 233-244, 2021 | 147 | 2021 |
| Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice K Yamamoto, Y Wang, W Jiang, X Liu, RL Dubois, CS Lin, T Ludwig, ... Journal of Cell Biology 198 (3), 305-313, 2012 | 130 | 2012 |
| Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma RA Parikh, JS White, X Huang, DW Schoppy, BE Baysal, R Baskaran, ... Genes, Chromosomes and Cancer 46 (8), 761-775, 2007 | 118 | 2007 |
| Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells P Teng, NW Bateman, KM Darcy, CA Hamilton, GL Maxwell, CJ Bakkenist, ... Gynecologic oncology 136 (3), 554-561, 2015 | 112 | 2015 |
| ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1 T Moiseeva, B Hood, S Schamus, MJ O’Connor, TP Conrads, ... Nature communications 8 (1), 1392, 2017 | 94 | 2017 |
| Disappearance of the telomere dysfunction-induced stress response in fully senescent cells CJ Bakkenist, R Drissi, J Wu, MB Kastan, JS Dome Cancer research 64 (11), 3748-3752, 2004 | 91 | 2004 |
| Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation JP Goff, DS Shields, M Seki, S Choi, MW Epperly, T Dixon, H Wang, ... Radiation research 172 (2), 165-174, 2009 | 90 | 2009 |
| ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage AM Gamper, R Rofougaran, SC Watkins, JS Greenberger, JH Beumer, ... Nucleic acids research 41 (22), 10334-10344, 2013 | 84 | 2013 |
| WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1-and S-phase cells TN Moiseeva, C Qian, N Sugitani, HU Osmanbeyoglu, CJ Bakkenist Proceedings of the National Academy of Sciences 116 (48), 23891-23893, 2019 | 81 | 2019 |
