| Cancer SLC43A2 alters T cell methionine metabolism and histone methylation Y Bian, W Li, DM Kremer, P Sajjakulnukit, S Li, J Crespo, ZC Nwosu, ... Nature 585 (7824), 277-282, 2020 | 423 | 2020 |
| Regulatory T-cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis Y Zhang, J Lazarus, NG Steele, W Yan, HJ Lee, ZC Nwosu, CJ Halbrook, ... Cancer discovery 10 (3), 422-439, 2020 | 333 | 2020 |
| Caveolin-1 in the regulation of cell metabolism: a cancer perspective ZC Nwosu, MP Ebert, S Dooley, C Meyer Molecular cancer 15, 1-12, 2016 | 229 | 2016 |
| Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer NG Steele, G Biffi, SB Kemp, Y Zhang, D Drouillard, LJ Syu, Y Hao, ... Clinical Cancer Research 27 (7), 2023-2037, 2021 | 225 | 2021 |
| GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis DM Kremer, BS Nelson, L Lin, EL Yarosz, CJ Halbrook, SA Kerk, ... Nature communications 12 (1), 4860, 2021 | 190 | 2021 |
| Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours ZC Nwosu, N Battello, M Rothley, W Piorońska, B Sitek, MP Ebert, ... Journal of Experimental & Clinical Cancer Research 37, 1-15, 2018 | 148 | 2018 |
| Identification of the consistently altered metabolic targets in human hepatocellular carcinoma ZC Nwosu, DA Megger, S Hammad, B Sitek, S Roessler, MP Ebert, ... Cellular and molecular gastroenterology and hepatology 4 (2), 303-323. e1, 2017 | 128 | 2017 |
| Apolipoprotein E promotes immune suppression in pancreatic cancer through NF-κB–mediated production of CXCL1 SB Kemp, ES Carpenter, NG Steele, KL Donahue, ZC Nwosu, A Pacheco, ... Cancer research 81 (16), 4305-4318, 2021 | 124 | 2021 |
| Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages SB Kemp, NG Steele, ES Carpenter, KL Donahue, GG Bushnell, ... Life science alliance 4 (6), 2021 | 86 | 2021 |
| Uridine-derived ribose fuels glucose-restricted pancreatic cancer ZC Nwosu, MH Ward, P Sajjakulnukit, P Poudel, C Ragulan, S Kasperek, ... Nature 618 (7963), 151-158, 2023 | 78 | 2023 |
| Arginase 1 is a key driver of immune suppression in pancreatic cancer RE Menjivar, ZC Nwosu, W Du, KL Donahue, HS Hong, C Espinoza, ... Elife 12, e80721, 2023 | 69 | 2023 |
| MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis L Tao, D Xue, D Shen, W Ma, J Zhang, X Wang, W Zhang, L Wu, K Pan, ... Archives of toxicology 92, 2935-2946, 2018 | 58 | 2018 |
| Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context SA Kerk, L Lin, AL Myers, DJ Sutton, A Andren, P Sajjakulnukit, L Zhang, ... Elife 11, e73245, 2022 | 55 | 2022 |
| Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance ZC Nwosu, W Piorońska, N Battello, AD Zimmer, B Dewidar, M Han, ... EBioMedicine 54, 2020 | 48 | 2020 |
| Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy BS Nelson, L Lin, DM Kremer, CM Sousa, C Cotta-Ramusino, A Myers, ... Cancer & metabolism 8, 1-16, 2020 | 39 | 2020 |
| Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC‐induced cholestatic liver injury A Addante, C Roncero, L Almalé, N Lazcanoiturburu, M García‐Álvaro, ... Liver International 38 (9), 1664-1675, 2018 | 36 | 2018 |
| Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis JJA Saab, LN Dzierozynski, PB Jonker, R AminiTabrizi, H Shah, ... Elife 12, e81289, 2023 | 34 | 2023 |
| The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells J Moreno-Càceres, D Caballero-Díaz, ZC Nwosu, C Meyer, ... Cell Death & Disease 8 (10), e3098-e3098, 2017 | 32 | 2017 |
| Hepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease M Han, W Piorońska, S Wang, ZC Nwosu, C Sticht, S Wang, Y Gao, ... Cell death & disease 11 (2), 104, 2020 | 31 | 2020 |
| Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation S Hammad, A Othman, C Meyer, A Telfah, J Lambert, B Dewidar, J Werle, ... Archives of toxicology 92, 2549-2561, 2018 | 31 | 2018 |
Costas LyssiotisProfessor of Physiology, University of MichiganVerified email at lyssiotis.com