| The BioPlex Network: A Systematic Exploration of the Human Interactome EL Huttlin, L Ting, RJ Bruckner, F Gebreab, MP Gygi, J Szpyt, S Tam, ... Cell 162 (2), 425-440, 2015 | 1534 | 2015 |
| Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways ET Cirulli, BN Lasseigne, S Petrovski, PC Sapp, PA Dion, CS Leblond, ... Science 347 (6229), 1436-1441, 2015 | 1060 | 2015 |
| The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy JM Heo, A Ordureau, JA Paulo, J Rinehart, JW Harper Molecular Cell 60 (1), 7-20, 2015 | 861 | 2015 |
| Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis A Ordureau, SA Sarraf, DM Duda, JM Heo, MP Jedrychowski, ... Molecular cell 56 (3), 360-375, 2014 | 736 | 2014 |
| Building and decoding ubiquitin chains for mitophagy JW Harper, A Ordureau, JM Heo Nature Reviews Molecular Cell Biology 19 (2), 93, 2018 | 596 | 2018 |
| Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains CH Emmerich, A Ordureau, S Strickson, JSC Arthur, PGA Pedrioli, ... Proceedings of the National Academy of Sciences 110 (38), 15247-15252, 2013 | 501 | 2013 |
| 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization RJ Nichols, N Dzamko, NA Morrice, DG Campbell, M Deak, A Ordureau, ... Biochemical Journal 430 (3), 393-404, 2010 | 441 | 2010 |
| Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress AM Pickrell, CH Huang, SR Kennedy, A Ordureau, DP Sideris, ... Neuron 87 (2), 371-381, 2015 | 350 | 2015 |
| Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy A Ordureau, JM Heo, DM Duda, JA Paulo, JL Olszewski, D Yanishevski, ... Proceedings of the National Academy of Sciences 112 (21), 6637-6642, 2015 | 346 | 2015 |
| TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress H An, A Ordureau, JA Paulo, CJ Shoemaker, V Denic, JW Harper Molecular cell 74 (5), 891-908. e10, 2019 | 261 | 2019 |
| The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 A Ordureau, H Smith, M Windheim, M Peggie, E Carrick, N Morrice, ... Biochemical journal 409 (1), 43-52, 2008 | 198 | 2008 |
| Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β CE Gleason, A Ordureau, R Gourlay, JSC Arthur, P Cohen Journal of Biological Chemistry 286 (41), 35663-35674, 2011 | 189 | 2011 |
| Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes CM Rose, M Isasa, A Ordureau, MA Prado, SA Beausoleil, ... Cell Systems 3 (4), 395-403. e4, 2016 | 185 | 2016 |
| System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ... Molecular cell 62 (1), 121-136, 2016 | 185 | 2016 |
| RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway JM Heo, A Ordureau, S Swarup, JA Paulo, K Shen, DM Sabatini, ... Science Advances 4 (11), eaav0443, 2018 | 178 | 2018 |
| TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling B Wang, Z Jie, D Joo, A Ordureau, P Liu, W Gan, J Guo, J Zhang, BJ North, ... Nature 545 (7654), 365-369, 2017 | 175 | 2017 |
| Polyubiquitin binding to ABIN1 is required to prevent autoimmunity SK Nanda, RKC Venigalla, A Ordureau, JC Patterson-Kane, DW Powell, ... Journal of Experimental Medicine 208 (6), 1215-1228, 2011 | 174 | 2011 |
| Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling A Ordureau, JA Paulo, J Zhang, H An, KN Swatek, JR Cannon, Q Wan, ... Molecular Cell 77 (5), 1124-1142. e10, 2020 | 173 | 2020 |
| Cyclin C is a haploinsufficient tumor suppressor N Li, A Fassl, J Chick, H Inuzuka, X Li, MR Mansour, L Liu, H Wang, ... Nature cell biology 16 (11), 1080, 2014 | 173 | 2014 |
| Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics A Ordureau, JA Paulo, W Zhang, T Ahfeldt, J Zhang, EF Cohn, Z Hou, ... Molecular cell 70 (2), 211-227. e8, 2018 | 172 | 2018 |
J.Wade HarperProfessor of Cell BiologyVerified email at hms.harvard.edu
