| Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease K Hou, J Zhao, H Wang, B Li, K Li, X Shi, K Wan, J Ai, J Lv, D Wang, ... Nature Communications 11 (1), 1-11, 2020 | 258 | 2020 |
| Cryo-EM structures of four polymorphic TDP-43 amyloid cores Q Cao, DR Boyer, MR Sawaya, P Ge, DS Eisenberg Nature Structural & Molecular Biology 26 (7), 619-627, 2019 | 237 | 2019 |
| Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation EL Guenther, Q Cao, H Trinh, J Lu, MR Sawaya, D Cascio, DR Boyer, ... Nature structural & molecular biology 25 (6), 463-471, 2018 | 234 | 2018 |
| Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils Q Cao, DR Boyer, MR Sawaya, P Ge, DS Eisenberg Nature Structural & Molecular Biology 27 (7), 653-659, 2020 | 134 | 2020 |
| Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43 YX Jiang, Q Cao, MR Sawaya, R Abskharon, P Ge, M DeTure, ... Nature 605 (7909), 304-309, 2022 | 123 | 2022 |
| Activation and regulation of caspase-6 and its role in neurodegenerative diseases XJ Wang, Q Cao, Y Zhang, XD Su Annual review of pharmacology and toxicology 55, 553-572, 2015 | 112 | 2015 |
| Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation WS Shin, J Di, Q Cao, B Li, PM Seidler, KA Murray, G Bitan, L Jiang Alzheimer's Research & Therapy 11 (1), 1-13, 2019 | 103 | 2019 |
| Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self‐activation XJ Wang, Q Cao, X Liu, KT Wang, W Mi, Y Zhang, LF Li, AC LeBlanc, ... EMBO reports 11 (11), 841-847, 2010 | 99 | 2010 |
| CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid J Lu, Q Cao, MP Hughes, MR Sawaya, DR Boyer, D Cascio, ... Nature Communications 11 (1), 1-11, 2020 | 94 | 2020 |
| Structure-based peptide inhibitor design of amyloid-β aggregation J Lu, Q Cao, C Wang, J Zheng, F Luo, J Xie, Y Li, X Ma, L He, ... Frontiers in molecular neuroscience 12, 54, 2019 | 78 | 2019 |
| Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design Q Cao, WS Shin, H Chan, CK Vuong, B Dubois, B Li, KA Murray, ... Nature chemistry 10 (12), 1213-1221, 2018 | 70 | 2018 |
| Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Q Cao, DR Boyer, MR Sawaya, R Abskharon, L Saelices, BA Nguyen, ... Nature Structural & Molecular Biology 28 (9), 724-730, 2021 | 65 | 2021 |
| The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein Y Sun, H Long, W Xia, K Wang, X Zhang, B Sun, Q Cao, Y Zhang, B Dai, ... Nature communications 12 (1), 1-10, 2021 | 62 | 2021 |
| Conformational change of α-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson’s disease Y Fan, Y Sun, W Yu, Y Tao, W Xia, Y Liu, Q Zhao, Y Tang, Y Sun, F Liu, ... Structure, 2022 | 37 | 2022 |
| Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays Q Cao, XJ Wang, CW Liu, DF Liu, LF Li, YQ Gao, XD Su Journal of Biological Chemistry 287 (19), 15371-15379, 2012 | 36 | 2012 |
| Molecular structure of an amyloid fibril formed by FUS low-complexity domain Y Sun, S Zhang, J Hu, Y Tao, W Xia, J Gu, Y Li, Q Cao, D Li, C Liu Iscience 25 (1), 103701, 2022 | 25 | 2022 |
| The inhibition of cellular toxicity of amyloid-β by dissociated transthyretin Q Cao, DH Anderson, WY Liang, J Chou, L Saelices Journal of Biological Chemistry 295 (41), 14015-14024, 2020 | 22 | 2020 |
| The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays Q Cao, XJ Wang, LF Li, XD Su Acta Crystallographica Section D: Biological Crystallography 70 (1), 58-67, 2014 | 17 | 2014 |
| Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM Y Cheng, J Han, M Song, S Zhang, Q Cao Nature Communications 14 (1), 7503, 2023 | 6 | 2023 |
| Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation J Lu, P Ge, MR Sawaya, MP Hughes, DR Boyer, Q Cao, R Abskharon, ... Journal of Biological Chemistry, 105531, 2023 | 1 | 2023 |
David S. EisenbergPaul Boyer Professor, HHMI-UCLAVerified email at mbi.ucla.edu
