| Combining microenvironment normalization strategies to improve cancer immunotherapy F Mpekris, C Voutouri, JW Baish, DG Duda, LL Munn, T Stylianopoulos, ... Proceedings of the National Academy of Sciences 117 (7), 3728-3737, 2020 | 213 | 2020 |
| Pirfenidone normalizes the tumor microenvironment to improve chemotherapy C Polydorou, F Mpekris, P Papageorgis, C Voutouri, T Stylianopoulos Oncotarget 8 (15), 24506, 2017 | 170 | 2017 |
| TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity M Panagi, C Voutouri, F Mpekris, P Papageorgis, MR Martin, JD Martin, ... Theranostics 10 (4), 1910, 2020 | 155 | 2020 |
| Hyaluronan-derived swelling of solid tumors, the contribution of collagen and cancer cells, and implications for cancer therapy C Voutouri, C Polydorou, P Papageorgis, V Gkretsi, T Stylianopoulos Neoplasia 18 (12), 732-741, 2016 | 133 | 2016 |
| Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors C Voutouri, F Mpekris, P Papageorgis, AD Odysseos, T Stylianopoulos PloS one 9 (8), e104717, 2014 | 132 | 2014 |
| Dexamethasone increases cisplatin-loaded nanocarrier delivery and efficacy in metastatic breast cancer by normalizing the tumor microenvironment JD Martin, M Panagi, C Wang, TT Khan, MR Martin, C Voutouri, K Toh, ... ACS nano 13 (6), 6396-6408, 2019 | 116 | 2019 |
| Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo-and nanotherapeutics in a size-independent manner P Papageorgis, C Polydorou, F Mpekris, C Voutouri, E Agathokleous, ... Scientific reports 7 (1), 46140, 2017 | 116 | 2017 |
| Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies C Voutouri, ND Kirkpatrick, E Chung, F Mpekris, JW Baish, LL Munn, ... Proceedings of the National Academy of Sciences 116 (7), 2662-2671, 2019 | 91 | 2019 |
| Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo-and nanotherapy F Mpekris, P Papageorgis, C Polydorou, C Voutouri, M Kalli, AP Pirentis, ... Journal of Controlled Release 261, 105-112, 2017 | 88 | 2017 |
| Normalizing the microenvironment overcomes vessel compression and resistance to nano‐immunotherapy in breast cancer lung metastasis F Mpekris, M Panagi, C Voutouri, JD Martin, R Samuel, S Takahashi, ... Advanced Science 8 (3), 2001917, 2021 | 85 | 2021 |
| Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness C Voutouri, T Stylianopoulos PloS one 13 (3), e0193801, 2018 | 80 | 2018 |
| Amphiphilic polymer conetworks based on end-linked “core-first” star block copolymers: Structure formation with long-range order EJ Kepola, E Loizou, CS Patrickios, E Leontidis, C Voutouri, ... ACS Macro Letters 4 (10), 1163-1168, 2015 | 61 | 2015 |
| Mechanical compression regulates brain cancer cell migration through MEK1/Erk1 pathway activation and GDF15 expression M Kalli, C Voutouri, A Minia, V Pliaka, C Fotis, LG Alexopoulos, ... Frontiers in oncology 9, 992, 2019 | 58 | 2019 |
| Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models M Panagi, F Mpekris, P Chen, C Voutouri, Y Nakagawa, JD Martin, T Hiroi, ... Nature Communications 13 (1), 7165, 2022 | 57 | 2022 |
| Evolution of osmotic pressure in solid tumors C Voutouri, T Stylianopoulos Journal of biomechanics 47 (14), 3441-3447, 2014 | 52 | 2014 |
| In silico dynamics of COVID-19 phenotypes for optimizing clinical management C Voutouri, MR Nikmaneshi, CC Hardin, AB Patel, A Verma, ... Proceedings of the National Academy of Sciences 118 (3), e2021642118, 2021 | 51 | 2021 |
| Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy F Mpekris, C Voutouri, M Panagi, JW Baish, RK Jain, T Stylianopoulos Journal of Controlled Release 345, 190-199, 2022 | 46 | 2022 |
| Double-networks based on pH-responsive, amphiphilic “core-first” star first polymer conetworks prepared by sequential RAFT polymerization EN Kitiri, CS Patrickios, C Voutouri, T Stylianopoulos, I Hoffmann, ... Polymer Chemistry 8 (1), 245-259, 2017 | 40 | 2017 |
| Nanomechanical properties of solid tumors as treatment monitoring biomarkers A Stylianou, F Mpekris, C Voutouri, A Papoui, A Constantinidou, E Kitiris, ... Acta Biomaterialia 154, 324-334, 2022 | 31 | 2022 |
| Endothelin inhibition potentiates cancer immunotherapy revealing mechanical biomarkers predictive of response C Voutouri, M Panagi, F Mpekris, A Stylianou, C Michael, MA Averkiou, ... Advanced Therapeutics 4 (9), 2000289, 2021 | 28 | 2021 |