sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers M Suárez‐Calvet, G Kleinberger, MÁ Araque Caballero, M Brendel, ... EMBO molecular medicine 8 (5), 466-476, 2016 | 511 | 2016 |
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE S Parhizkar, T Arzberger, M Brendel, G Kleinberger, M Deussing, C Focke, ... Nature neuroscience 22 (2), 191-204, 2019 | 508 | 2019 |
White matter aging drives microglial diversity S Safaiyan, S Besson-Girard, T Kaya, L Cantuti-Castelvetri, L Liu, H Ji, ... Neuron 109 (7), 1100-1117. e10, 2021 | 329 | 2021 |
The FTD‐like syndrome causing TREM 2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism G Kleinberger, M Brendel, E Mracsko, B Wefers, L Groeneweg, X Xiang, ... The EMBO journal 36 (13), 1837-1853, 2017 | 210 | 2017 |
Assessment of 18F-PI-2620 as a biomarker in progressive supranuclear palsy M Brendel, H Barthel, T van Eimeren, K Marek, L Beyer, M Song, C Palleis, ... JAMA neurology 77 (11), 1408-1419, 2020 | 203 | 2020 |
Four-repeat tauopathies TW Roesler, AT Marvian, M Brendel, NP Nykaenen, M Höllerhage, ... Progress in neurobiology 180, 101644, 2019 | 203 | 2019 |
EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3 E Guedj, A Varrone, R Boellaard, NL Albert, H Barthel, B van Berckel, ... European journal of nuclear medicine and molecular imaging, 1-20, 2022 | 192 | 2022 |
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases X Xiang, K Wind, T Wiedemann, T Blume, Y Shi, N Briel, L Beyer, ... Science translational medicine 13 (615), eabe5640, 2021 | 182 | 2021 |
Improved longitudinal [18F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction M Brendel, M Högenauer, A Delker, J Sauerbeck, P Bartenstein, J Seibyl, ... Neuroimage 108, 450-459, 2015 | 151 | 2015 |
Glial activation and glucose metabolism in a transgenic amyloid mouse model: a triple-tracer PET study M Brendel, F Probst, A Jaworska, F Overhoff, V Korzhova, NL Albert, ... Journal of Nuclear Medicine 57 (6), 954-960, 2016 | 150 | 2016 |
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 143 | 2023 |
Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects M Ewers, M Brendel, A Rizk-Jackson, A Rominger, P Bartenstein, ... NeuroImage: Clinical 4, 45-52, 2014 | 133 | 2014 |
Evaluation of early-phase [18F]-florbetaben PET acquisition in clinical routine cases S Daerr, M Brendel, C Zach, E Mille, D Schilling, MJ Zacherl, K Bürger, ... NeuroImage: Clinical 14, 77-86, 2017 | 120 | 2017 |
Early static 18F-FET-PET scans have a higher accuracy for glioma grading than the standard 20–40 min scans NL Albert, I Winkelmann, B Suchorska, V Wenter, C Schmid-Tannwald, ... European journal of nuclear medicine and molecular imaging 43, 1105-1114, 2016 | 117 | 2016 |
TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma NL Albert, M Unterrainer, DF Fleischmann, S Lindner, F Vettermann, ... European journal of nuclear medicine and molecular imaging 44, 2230-2238, 2017 | 111 | 2017 |
Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients M Brendel, O Pogarell, G Xiong, A Delker, P Bartenstein, A Rominger, ... European journal of nuclear medicine and molecular imaging 42, 716-724, 2015 | 110 | 2015 |
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation M Ewers, G Biechele, M Suárez‐Calvet, C Sacher, T Blume, ... EMBO molecular medicine 12 (9), e12308, 2020 | 108 | 2020 |
Opposite microglial activation stages upon loss of PGRN or TREM 2 result in reduced cerebral glucose metabolism JK Götzl, M Brendel, G Werner, S Parhizkar, L Sebastian Monasor, ... EMBO molecular medicine 11 (6), e9711, 2019 | 108 | 2019 |
Towards standardization of 18F-FET PET imaging: do we need a consistent method of background activity assessment? M Unterrainer, F Vettermann, M Brendel, A Holzgreve, M Lifschitz, ... EJNMMI research 7, 1-8, 2017 | 107 | 2017 |
Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals D Biel, M Brendel, A Rubinski, K Buerger, D Janowitz, M Dichgans, ... Alzheimer's research & therapy 13 (1), 137, 2021 | 105 | 2021 |