| A community effort to assess and improve drug sensitivity prediction algorithms JC Costello, LM Heiser, E Georgii, M Gönen, MP Menden, NJ Wang, ... Nature biotechnology 32 (12), 1202-1212, 2014 | 817 | 2014 |
| Subtype and pathway specific responses to anticancer compounds in breast cancer LM Heiser, A Sadanandam, WL Kuo, SC Benz, TC Goldstein, S Ng, ... Proceedings of the National Academy of Sciences 109 (8), 2724-2729, 2012 | 552 | 2012 |
| How machine learning will transform biomedicine J Goecks, V Jalili, LM Heiser, JW Gray Cell 181 (1), 92-101, 2020 | 458 | 2020 |
| Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition OK Mirzoeva, D Das, LM Heiser, S Bhattacharya, D Siwak, R Gendelman, ... Cancer research 69 (2), 565-572, 2009 | 444 | 2009 |
| The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ... Cell systems 6 (1), 13-24, 2018 | 436 | 2018 |
| Metrics other than potency reveal systematic variation in responses to cancer drugs M Fallahi-Sichani, S Honarnejad, LM Heiser, JW Gray, PK Sorger Nature chemical biology 9 (11), 708, 2013 | 379 | 2013 |
| A central role for RAF→ MEK→ ERK signaling in the genesis of pancreatic ductal adenocarcinoma EA Collisson, CL Trejo, JM Silva, S Gu, JE Korkola, LM Heiser, ... Cancer discovery 2 (8), 685-693, 2012 | 365 | 2012 |
| Tumor-derived Cell Lines as Molecular Models of Cancer Pharmacogenomics A Goodspeed, LM Heiser, JW Gray, JC Costello Molecular Cancer Research 14 (1), 3-13, 2016 | 354 | 2016 |
| Modeling precision treatment of breast cancer A Daemen, OL Griffith, LM Heiser, NJ Wang, OM Enache, Z Sanborn, ... Genome biology 14 (10), R110, 2013 | 345 | 2013 |
| A community computational challenge to predict the activity of pairs of compounds M Bansal, J Yang, C Karan, MP Menden, JC Costello, H Tang, G Xiao, ... Nature biotechnology 32 (12), 1213-1222, 2014 | 343 | 2014 |
| Inferring causal molecular networks: empirical assessment through a community-based effort SM Hill, LM Heiser, T Cokelaer, M Unger, NK Nesser, DE Carlin, Y Zhang, ... Nature methods 13 (4), 310-318, 2016 | 260 | 2016 |
| LSD1 activates a lethal prostate cancer gene network independently of its demethylase function A Sehrawat, L Gao, Y Wang, A Bankhead, SK McWeeney, CJ King, ... Proceedings of the National Academy of Sciences, 201719168, 2018 | 230 | 2018 |
| FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer X Fu, R Jeselsohn, R Pereira, EF Hollingsworth, CJ Creighton, F Li, ... Proceedings of the National Academy of Sciences, 201612835, 2016 | 170 | 2016 |
| Combating subclonal evolution of resistant cancer phenotypes SW Brady, JA McQuerry, Y Qiao, SR Piccolo, G Shrestha, DF Jenkins, ... Nature communications 8 (1), 1231, 2017 | 163 | 2017 |
| Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with anti-HER2 therapy M Giuliano, H Hu, YC Wang, X Fu, A Nardone, S Herrera, S Mao, ... Clinical Cancer Research 21 (17), 3995-4003, 2015 | 135 | 2015 |
| A multi-center study on the reproducibility of drug-response assays in mammalian cell lines M Niepel, M Hafner, CE Mills, K Subramanian, EH Williams, M Chung, ... Cell systems 9 (1), 35-48. e5, 2019 | 134 | 2019 |
| Bayesian inference of signaling network topology in a cancer cell line SM Hill, Y Lu, J Molina, LM Heiser, PT Spellman, TP Speed, JW Gray, ... Bioinformatics 28 (21), 2804-2810, 2012 | 128 | 2012 |
| HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer X Xu, C De Angelis, KA Burke, A Nardone, H Hu, L Qin, J Veeraraghavan, ... Clinical Cancer Research, clincanres. 2191.2016, 2017 | 118 | 2017 |
| MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance AS Farrell, MM Joly, BL Allen-Petersen, PJ Worth, C Lanciault, D Sauer, ... Nature Communications 8 (1), 1728, 2017 | 108 | 2017 |
| Spatial updating in area LIP is independent of saccade direction LM Heiser, CL Colby Journal of neurophysiology 95 (5), 2751-2767, 2006 | 107 | 2006 |
Joe GrayBiomedical Engineering, Oregon Health and Science UniversityVerified email at ohsu.edu
