| Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate O Cuvillier, G Pirianov, B Kleuser, PG Vanek, OA Coso, JS Gutkind, ... Nature 381 (6585), 800-803, 1996 | 1940 | 1996 |
| Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival A Olivera, T Kohama, L Edsall, V Nava, O Cuvillier, S Poulton, S Spiegel The Journal of cell biology 147 (3), 545-558, 1999 | 678 | 1999 |
| Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival JR Van Brocklyn, MJ Lee, R Menzeleev, A Olivera, L Edsall, O Cuvillier, ... The Journal of cell biology 142 (1), 229-240, 1998 | 584 | 1998 |
| Sphingosine in apoptosis signaling O Cuvillier Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2002 | 447 | 2002 |
| Sphingosine 1-phosphate inhibits activation of caspases that cleave poly (ADP-ribose) polymerase and lamins during Fas-and ceramide-mediated apoptosis in Jurkat T lymphocytes O Cuvillier, DS Rosenthal, ME Smulson, S Spiegel Journal of Biological Chemistry 273 (5), 2910-2916, 1998 | 329 | 1998 |
| N, N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide LC Edsall, JR Van Brocklyn, O Cuvillier, B Kleuser, S Spiegel Biochemistry 37 (37), 12892-12898, 1998 | 293 | 1998 |
| Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models D Pchejetski, M Golzio, E Bonhoure, C Calvet, N Doumerc, V Garcia, ... Cancer research 65 (24), 11667-11675, 2005 | 277 | 2005 |
| Sphingosine‐1‐Phosphate in Cell Growth and Cell Deatha S Spiegel, O Cuvillier, LC Edsall, T Kohama, R Menzeleev, Z Olah, ... Annals of the New York Academy of Sciences 845 (1), 11-18, 1998 | 251 | 1998 |
| Oxidative stress–dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A–associated cardiac cell apoptosis D Pchejetski, O Kunduzova, A Dayon, D Calise, MH Seguelas, N Leducq, ... Circulation research 100 (1), 41-49, 2007 | 240 | 2007 |
| Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells LC Edsall, O Cuvillier, S Twitty, S Spiegel, S Milstien Journal of neurochemistry 76 (5), 1573-1584, 2001 | 235 | 2001 |
| Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1 E Bonhoure, D Pchejetski, N Aouali, H Morjani, T Levade, T Kohama, ... Leukemia 20 (1), 95-102, 2006 | 233 | 2006 |
| Sphingolipid mediators in cardiovascular cell biology and pathology T Levade, N Augé, RJ Veldman, O Cuvillier, A Nègre-Salvayre, ... Circulation research 89 (11), 957-968, 2001 | 233 | 2001 |
| Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells O Cuvillier, L Edsall, S Spiegel Journal of Biological Chemistry 275 (21), 15691-15700, 2000 | 215 | 2000 |
| Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells VE Nava, O Cuvillier, LC Edsall, K Kimura, S Milstien, EP Gelmann, ... Cancer Research 60 (16), 4468-4474, 2000 | 199 | 2000 |
| Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis J Guillermet, N Saint-Laurent, P Rochaix, O Cuvillier, T Levade, ... Proceedings of the National Academy of Sciences 100 (1), 155-160, 2003 | 193 | 2003 |
| Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria O Cuvillier, T Levade Blood, The Journal of the American Society of Hematology 98 (9), 2828-2836, 2001 | 192 | 2001 |
| Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug J Guillermet-Guibert, L Davenne, D Pchejetski, N Saint-Laurent, ... Molecular cancer therapeutics 8 (4), 809-820, 2009 | 183 | 2009 |
| Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells O Cuvillier, VE Nava, SK Murthy, LC Edsall, T Levade, S Milstien, ... Cell Death & Differentiation 8 (2), 162-171, 2001 | 178 | 2001 |
| Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1α during hypoxia in human cancer cells I Ader, L Brizuela, P Bouquerel, B Malavaud, O Cuvillier Cancer research 68 (20), 8635-8642, 2008 | 176 | 2008 |
| FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1 D Pchejetski, T Bohler, L Brizuela, L Sauer, N Doumerc, M Golzio, ... Cancer research 70 (21), 8651-8661, 2010 | 172 | 2010 |
Sarah SpiegelProfessor of Biochemistry and Molecular Biology, VCUVerified email at vcuhealth.org