| Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells MB Dong, G Wang, RD Chow, L Ye, L Zhu, X Dai, JJ Park, HR Kim, ... Cell 178 (5), 1189-1204. e23, 2019 | 277 | 2019 |
| AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma RD Chow, CD Guzman, G Wang, F Schmidt, MW Youngblood, L Ye, ... Nature neuroscience 20 (10), 1329-1341, 2017 | 246 | 2017 |
| In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma L Ye, JJ Park, MB Dong, Q Yang, RD Chow, L Peng, Y Du, J Guo, X Dai, ... Nature biotechnology 37 (11), 1302-1313, 2019 | 169 | 2019 |
| A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy L Ye, JJ Park, L Peng, Q Yang, RD Chow, MB Dong, SZ Lam, J Guo, ... Cell metabolism 34 (4), 595-614. e14, 2022 | 125 | 2022 |
| Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity G Wang, RD Chow, Z Bai, L Zhu, Y Errami, X Dai, MB Dong, L Ye, ... Nature Immunology 20 (11), 1494-1505, 2019 | 109 | 2019 |
| CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade G Wang, RD Chow, L Zhu, Z Bai, L Ye, F Zhang, PA Renauer, MB Dong, ... Cancer discovery 10 (12), 1912-1933, 2020 | 106 | 2020 |
| Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening G Wang, RD Chow, L Ye, CD Guzman, X Dai, MB Dong, F Zhang, ... Science advances 4 (2), eaao5508, 2018 | 98 | 2018 |
| Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9 L Ye, C Wang, L Hong, N Sun, D Chen, S Chen, F Han Cell discovery 4 (1), 46, 2018 | 67 | 2018 |
| In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens RD Chow, G Wang, L Ye, A Codina, HR Kim, L Shen, MB Dong, Y Errami, ... Nature methods 16 (5), 405-408, 2019 | 60 | 2019 |
| Comparative proteomic and phosphoproteomic analysis of the silkworm (Bombyx mori) posterior silk gland under high temperature treatment J Li, L Ye, T Lan, M Yu, J Liang, B Zhong Molecular biology reports 39, 8447-8456, 2012 | 42 | 2012 |
| Quantitative Proteomic and Transcriptomic Analyses of Molecular Mechanisms Associated with Low Silk Production in Silkworm Bombyx mori S Wang, Z You, L Ye, J Che, Q Qian, Y Nanjo, S Komatsu, B Zhong Journal of proteome research 13 (2), 735-751, 2014 | 38 | 2014 |
| MicroRNA expression profiling of the fifth-instar posterior silk gland of Bombyx mori J Li, Y Cai, L Ye, S Wang, J Che, Z You, J Yu, B Zhong BMC genomics 15, 1-11, 2014 | 35 | 2014 |
| Comparative proteomic analysis of the silkworm middle silk gland reveals the importance of ribosome biogenesis in silk protein production J Li, L Ye, J Che, J Song, Z You, K Yun, S Wang, B Zhong Journal of proteomics 126, 109-120, 2015 | 34 | 2015 |
| Extraordinary mechanical properties of composite silk through hereditable transgenic silkworm expressing recombinant major ampullate spidroin Z You, X Ye, L Ye, Q Qian, M Wu, J Song, J Che, B Zhong Scientific Reports 8 (1), 15956, 2018 | 32 | 2018 |
| CRISPR-Sunspot: Imaging of endogenous low-abundance RNA at the single-molecule level in live cells NH Sun, DY Chen, LP Ye, G Sheng, JJ Gong, BH Chen, YM Lu, F Han Theranostics 10 (24), 10993, 2020 | 27 | 2020 |
| Convergent identification and interrogation of tumor-intrinsic factors that modulate cancer immunity in vivo A Codina, PA Renauer, G Wang, RD Chow, JJ Park, H Ye, K Zhang, ... Cell systems 8 (2), 136-151. e7, 2019 | 21 | 2019 |
| Prdm6 controls heart development by regulating neural crest cell differentiation and migration L Hong, N Li, V Gasque, S Mehta, L Ye, Y Wu, J Li, A Gewies, J Ruland, ... JCI insight 7 (4), 2022 | 18 | 2022 |
| AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells L Ye, SZ Lam, L Yang, K Suzuki, Y Zou, Q Lin, Y Zhang, P Clark, L Peng, ... Nature Biomedical Engineering 8 (2), 132-148, 2024 | 17 | 2024 |
| Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B. 1.617 L Peng, Y Hu, MC Mankowski, P Ren, RE Chen, J Wei, M Zhao, T Li, ... Nature communications 13 (1), 1638, 2022 | 17 | 2022 |
| High-efficiency production of human serum albumin in the posterior silk glands of transgenic silkworms, Bombyx mori L Q Qian, Z You, L Ye, J Che, Y Wang, S Wang, B Zhong PLoS One 13 (1), e0191507, 2018 | 17 | 2018 |
Sidi Chen, PhDYale University (Previous: MIT, Broad Institute, University of Chicago)Verified email at yale.edu
