Jacques Pouyssegur

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Nathalie MazureCNRSVerified email at unice.fr
jean claude ChambardcnrsVerified email at unice.fr
Ellen Van Obberghen-SchillingVerified email at unice.fr
Scott K. ParksPost-doctoral Scientist, Centre Scientifique de MonacoVerified email at centrescientifique.mc
Anne BrunetProfessor of Genetics, Stanford UniversityVerified email at stanford.edu
Darren E RichardFull Professor, Université LavalVerified email at crchudequebec.ulaval.ca
Sylvain MelocheInstitute of Research in Immunology and Cancer, Université de MontréalVerified email at umontreal.ca
Jerome DurivaultCentre Scientifique de MonacoVerified email at centrescientifique.mc
Mark DonowitzProfessor of Medicine and Physiology, Johns Hopkins University School of MedicineVerified email at jhmi.edu
Maša ŽdralevićUniversity of Montenegro, Institute for Advanced StudiesVerified email at ucg.ac.me
Guido KroemerUniversité de Paris Cité, Hôpital Européen George Pompidou - AP-HP, Gustave Roussy Cancer CampusVerified email at inserm.fr
Chris YunProfessor of Medicine, Emory UniversityVerified email at emory.edu
Bernard MariDirecteur de Recherche CNRSVerified email at unice.fr
Sergio GrinsteinSenior Scientist, Hospital for Sick Children, Cell Biology ProgramVerified email at sickkids.ca
Josee N. LavoieCentre de recherche du CHU de Québec-Université LavalVerified email at crchudequebec.ulaval.ca
Stephen M HedrickUniversity of California, San DiegoVerified email at ucsd.edu
Nathalie RivardVerified email at usherbrooke.ca
Maude Le GallInserm, Université Paris CitéVerified email at inserm.fr
Pascal BarbryDirecteur de Recherches, IHU RespirERA, 3IA Côte d'Azur, CNRS, Inserm, University Cote d'AzurVerified email at ipmc.cnrs.fr
Kenneth M YamadaNIH, NIDCRVerified email at nih.gov

Jacques Pouyssegur

IRCAN, Centre A. Lacassagne, University of Nice and Centre Scientifique de Monaco (CSM)

Verified email at unice.fr - Homepage

Hypoxia signaling Nutritional Stress pHi regulation Cancer Metabolism


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Tumor cell metabolism: cancer's Achilles' heel G Kroemer, J Pouyssegur Cancer cell 13 (6), 472-482, 2008	2813	2008
Hypoxia signalling in cancer and approaches to enforce tumour regression J Pouysségur, F Dayan, NM Mazure Nature 441 (7092), 437-443, 2006	2115	2006
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia E Berra, E Benizri, A Ginouvès, V Volmat, D Roux, J Pouysségur The EMBO journal, 2003	1789	2003
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains G Bellot, R Garcia-Medina, P Gounon, J Chiche, D Roux, J Pouysségur, ... Molecular and cellular biology, 2009	1689	2009
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway JN Lavoie, G L'Allemain, A Brunet, R Müller, J Pouysségur Journal of Biological Chemistry 271 (34), 20608-20616, 1996	1637	1996
LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells A Brand, K Singer, GE Koehl, M Kolitzus, G Schoenhammer, A Thiel, ... Cell metabolism 24 (5), 657-671, 2016	1556	2016
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition S Meloche, J Pouysségur Oncogene 26 (22), 3227-3239, 2007	1401	2007
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. G Pages, P Lenormand, G L'Allemain, JC Chambard, S Meloche, ... Proceedings of the National Academy of Sciences 90 (18), 8319-8323, 1993	1296	1993
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1 DE Richard, E Berra, E Gothié, D Roux, J Pouysségur Journal of Biological Chemistry 274 (46), 32631-32637, 1999	1067	1999
Hypoxia and cancer MC Brahimi-Horn, J Chiche, J Pouysségur Journal of molecular medicine 85, 1301-1307, 2007	1004	2007
Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+ H+ antiporter C Sardet, A Franchi, J Pouysségur Cell 56 (2), 271-280, 1989	985	1989
ERK implication in cell cycle regulation JC Chambard, R Lefloch, J Pouysségur, P Lenormand Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1773 (8), 1299-1310, 2007	981	2007
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity EP Cummins, E Berra, KM Comerford, A Ginouves, KT Fitzgerald, ... Proceedings of the National Academy of Sciences 103 (48), 18154-18159, 2006	947	2006
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice G Pagès, S Guérin, D Grall, F Bonino, A Smith, F Anjuere, P Auberger, ... Science 286 (5443), 1374-1377, 1999	918	1999
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells DE Richard, E Berra, J Pouysségur Journal of Biological Chemistry 275 (35), 26765-26771, 2000	880	2000
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH J Chiche, K Ilc, J Laferriere, E Trottier, F Dayan, NM Mazure, ... Cancer research 69 (1), 358-368, 2009	874	2009
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts P Lenormand, C Sardet, G Pages, G L'Allemain, A Brunet, J Pouysségur The Journal of cell biology 122 (5), 1079-1088, 1993	863	1993
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer J Chiche, MC Brahimi‐Horn, J Pouysségur Journal of cellular and molecular medicine 14 (4), 771-794, 2010	819	2010
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling J Pouysségur, V Volmat, P Lenormand Biochemical pharmacology 64 (5-6), 755-763, 2002	796*	2002
Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry A Brunet, D Roux, P Lenormand, S Dowd, S Keyse, J Pouysségur The EMBO journal, 1999	768	1999

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