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| RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS Y Ito, D Ofengeim, A Najafov, S Das, S Saberi, Y Li, J Hitomi, H Zhu, ... Science 353 (6299), 603-608, 2016 | 578 | 2016 |
| A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader HT Huang, D Dobrovolsky, J Paulk, G Yang, EL Weisberg, ZM Doctor, ... Cell chemical biology 25 (1), 88-99. e6, 2018 | 427 | 2018 |
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| Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation Z Liu, S Zhang, J Gu, Y Tong, Y Li, X Gui, H Long, C Wang, C Zhao, J Lu, ... Nature structural & molecular biology 27 (4), 363-372, 2020 | 147 | 2020 |
| Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis H Meng, Z Liu, X Li, H Wang, T Jin, G Wu, B Shan, DE Christofferson, C Qi, ... Proceedings of the National Academy of Sciences 115 (9), E2001-E2009, 2018 | 140 | 2018 |
| TAM kinases promote necroptosis by regulating oligomerization of MLKL A Najafov, AK Mookhtiar, HS Luu, A Ordureau, H Pan, PP Amin, Y Li, Q Lu, ... Molecular cell 75 (3), 457-468. e4, 2019 | 121 | 2019 |
| PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP H Wang, H Meng, X Li, K Zhu, K Dong, AK Mookhtiar, H Wei, Y Li, SC Sun, ... Proceedings of the National Academy of Sciences 114 (45), 11944-11949, 2017 | 119 | 2017 |
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| Modification of BECN1 by ISG15 Plays a Crucial Role in Autophagy Regulation by Type I IFN/interferon D Xu, T Zhang, J Xiao, K Zhu, R Wei, Z Wu, H Meng, Y Li, J Yuan Autophagy 11 (4), 617-628, 2015 | 95 | 2015 |
| SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation G Xu, Y Li, S Zhang, H Peng, Y Wang, D Li, T Jin, Z He, Y Tong, C Qi, ... Cell research 31 (12), 1230-1243, 2021 | 90 | 2021 |
| Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2 H Shan, J Liu, J Shen, J Dai, G Xu, K Lu, C Han, Y Wang, X Xu, Y Tong, ... Cell chemical biology 28 (6), 855-865. e9, 2021 | 88 | 2021 |
| 17-Acetoxyjolkinolide B irreversibly inhibits IκB kinase and induces apoptosis of tumor cells SS Yan, Y Li, Y Wang, SS Shen, Y Gu, HB Wang, GW Qin, Q Yu Molecular Cancer Therapeutics 7 (6), 1523-1532, 2008 | 69 | 2008 |
| NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation H Wang, W Qi, C Zou, Z Xie, M Zhang, MG Naito, L Mifflin, Z Liu, A Najafov, ... Nature communications 12 (1), 4826, 2021 | 38 | 2021 |
| A novel necroptosis inhibitor—necrostatin-21 and its SAR study Z Wu, Y Li, Y Cai, J Yuan, C Yuan Bioorganic & medicinal chemistry letters 23 (17), 4903-4906, 2013 | 37 | 2013 |
| HOIP modulates the stability of GPx4 by linear ubiquitination K Dong, R Wei, T Jin, M Zhang, J Shen, H Xiang, B Shan, J Yuan, Y Li Proceedings of the National Academy of Sciences 119 (44), e2214227119, 2022 | 31 | 2022 |
| Dual inhibition of CDK12/CDK13 targets both tumor and immune cells in ovarian cancer L Cheng, S Zhou, S Zhou, K Shi, Y Cheng, MC Cai, K Ye, L Lin, Z Zhang, ... Cancer Research 82 (19), 3588-3602, 2022 | 26 | 2022 |
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Junying YuanProfessor, Interdisciplinary Research Center on Biology and Chemistry, Shanghai, ChinaVerified email at hms.harvard.edu