| Structure-based discovery of β2-adrenergic receptor ligands P Kolb, DM Rosenbaum, JJ Irwin, JJ Fung, BK Kobilka, BK Shoichet Proceedings of the National Academy of Sciences 106 (16), 6843-6848, 2009 | 357 | 2009 |
| GPCRdb: the G protein‐coupled receptor database–an introduction C Munk, V Isberg, S Mordalski, K Harpsøe, K Rataj, AS Hauser, P Kolb, ... British journal of pharmacology 173 (14), 2195-2207, 2016 | 247 | 2016 |
| Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant J Yin, JC Mobarec, P Kolb, DM Rosenbaum Nature 519 (7542), 247-250, 2015 | 243 | 2015 |
| Docking and chemoinformatic screens for new ligands and targets P Kolb, RS Ferreira, JJ Irwin, BK Shoichet Current opinion in biotechnology 20 (4), 429-436, 2009 | 238 | 2009 |
| Community guidelines for GPCR ligand bias: IUPHAR review 32 P Kolb, T Kenakin, SPH Alexander, M Bermudez, LM Bohn, CS Breinholt, ... British journal of pharmacology 179 (14), 3651-3674, 2022 | 157 | 2022 |
| Docking screens: right for the right reasons? P Kolb, JJ Irwin Current Topics in Medicinal Chemistry 9 (9), 755-770, 2009 | 152 | 2009 |
| GPCRmd uncovers the dynamics of the 3D-GPCRome I Rodríguez-Espigares, M Torrens-Fontanals, JKS Tiemann, ... Nature Methods 17 (8), 777-787, 2020 | 142 | 2020 |
| Direct targeting of Gαq and Gα11 oncoproteins in cancer cells S Annala, X Feng, N Shridhar, F Eryilmaz, J Patt, JH Yang, EM Pfeil, ... Sci. Signal. 12 (573), eaau5948, 2019 | 118 | 2019 |
| Automatic and efficient decomposition of two-dimensional structures of small molecules for fragment-based high-throughput docking P Kolb, A Caflisch Journal of medicinal chemistry 49 (25), 7384-7392, 2006 | 110 | 2006 |
| Discovery of Cell-Permeable Non-Peptide Inhibitors of β-Secretase by High-Throughput Docking and Continuum Electrostatics Calculations# D Huang, U Lüthi, P Kolb, K Edler, M Cecchini, S Audetat, A Barberis, ... Journal of medicinal chemistry 48 (16), 5108-5111, 2005 | 109 | 2005 |
| SCUBIDOO: A Large yet Screenable and Easily Searchable Database of Computationally Created Chemical Compounds Optimized toward High Likelihood of Synthetic Tractability F Chevillard, P Kolb Journal of chemical information and modeling 55 (9), 1824-1835, 2015 | 108 | 2015 |
| In silico discovery of β-secretase inhibitors D Huang, U Lüthi, P Kolb, M Cecchini, A Barberis, A Caflisch Journal of the American Chemical Society 128 (16), 5436-5443, 2006 | 105 | 2006 |
| Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next‐Generation Anticoagulants M Stieler, J Weber, M Hils, P Kolb, A Heine, C Büchold, R Pasternack, ... Angewandte Chemie International Edition 52 (45), 11930-11934, 2013 | 99 | 2013 |
| Functional Annotation and Three-Dimensional Structure of Dr0930 from Deinococcus radiodurans, a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily†‡ DF Xiang, P Kolb, AA Fedorov, MM Meier, LV Fedorov, TT Nguyen, ... Biochemistry 48 (10), 2237-2247, 2009 | 98 | 2009 |
| Virtual compound libraries in computer-assisted drug discovery N van Hilten, F Chevillard, P Kolb Journal of chemical information and modeling 59 (2), 644-651, 2019 | 83 | 2019 |
| Virtual Compound Libraries in Computer-Assisted Drug Discovery N van Hilten, F Chevillard, P Kolb Journal of chemical information and modeling 59 (2), 644-651, 2019 | 83 | 2019 |
| Automated docking of highly flexible ligands by genetic algorithms: A critical assessment M Cecchini, P Kolb, N Majeux, A Caflisch Journal of computational chemistry 25 (3), 412-422, 2004 | 76 | 2004 |
| The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites JB Hedderich, M Persechino, K Becker, FM Heydenreich, T Gutermuth, ... Nature Communications 13 (1), 2567, 2022 | 73 | 2022 |
| Structure‐based tailoring of compound libraries for high‐throughput screening: Discovery of novel EphB4 kinase inhibitors P Kolb, CB Kipouros, D Huang, A Caflisch Proteins: Structure, Function, and Bioinformatics 73 (1), 11-18, 2008 | 73 | 2008 |
| The mode of agonist binding to a G protein–coupled receptor switches the effect that voltage changes have on signaling A Rinne, JC Mobarec, M Mahaut-Smith, P Kolb, M Bünemann Sci. Signal. 8 (401), ra110-ra110, 2015 | 71 | 2015 |
Amedeo CaflischDepartment of Biochemistry, University of ZurichVerified email at bioc.uzh.ch