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| Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 trial CS Fuchs, T Doi, RW Jang, K Muro, T Satoh, M Machado, W Sun, SI Jalal, ... JAMA oncology 4 (5), e180013-e180013, 2018 | 1843 | 2018 |
| Regulatory T cells in cancer immunosuppression—implications for anticancer therapy Y Togashi, K Shitara, H Nishikawa Nature reviews Clinical oncology 16 (6), 356-371, 2019 | 1348 | 2019 |
| Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial K Shitara, M Özgüroğlu, YJ Bang, M Di Bartolomeo, M Mandalà, MH Ryu, ... The Lancet 392 (10142), 123-133, 2018 | 1273 | 2018 |
| Trastuzumab deruxtecan in previously treated HER2-positive gastric cancer K Shitara, YJ Bang, S Iwasa, N Sugimoto, MH Ryu, D Sakai, HC Chung, ... New England Journal of Medicine 382 (25), 2419-2430, 2020 | 1095 | 2020 |
| Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line, advanced gastric cancer: the KEYNOTE-062 phase 3 … K Shitara, E Van Cutsem, YJ Bang, C Fuchs, L Wyrwicz, KW Lee, ... JAMA oncology 6 (10), 1571-1580, 2020 | 1001 | 2020 |
| PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer T Kamada, Y Togashi, C Tay, D Ha, A Sasaki, Y Nakamura, E Sato, ... Proceedings of the National Academy of Sciences 116 (20), 9999-10008, 2019 | 922 | 2019 |
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| The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies S Kumagai, Y Togashi, T Kamada, E Sugiyama, H Nishinakamura, ... Nature immunology 21 (11), 1346-1358, 2020 | 678 | 2020 |
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| Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an … PC Thuss-Patience, MA Shah, A Ohtsu, E Van Cutsem, JA Ajani, H Castro, ... The lancet oncology 18 (5), 640-653, 2017 | 562 | 2017 |
| Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal … YK Kang, LT Chen, MH Ryu, DY Oh, SC Oh, HC Chung, KW Lee, T Omori, ... The Lancet Oncology 23 (2), 234-247, 2022 | 536 | 2022 |
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| Trifluridine/tipiracil versus placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomised, double-blind, placebo-controlled, phase 3 trial K Shitara, T Doi, M Dvorkin, W Mansoor, HT Arkenau, A Prokharau, ... The Lancet Oncology 19 (11), 1437-1448, 2018 | 487 | 2018 |
| Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody–drug conjugate, in patients with advanced breast and gastric or … T Doi, K Shitara, Y Naito, A Shimomura, Y Fujiwara, K Yonemori, ... The Lancet Oncology 18 (11), 1512-1522, 2017 | 479 | 2017 |
| BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer T Yokota, T Ura, N Shibata, D Takahari, K Shitara, M Nomura, C Kondo, ... British journal of cancer 104 (5), 856-862, 2011 | 471 | 2011 |
| Zolbetuximab plus mFOLFOX6 in patients with CLDN18. 2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction … K Shitara, F Lordick, YJ Bang, P Enzinger, D Ilson, MA Shah, ... The Lancet 401 (10389), 1655-1668, 2023 | 403 | 2023 |
| Assessment of pembrolizumab therapy for the treatment of microsatellite instability–high gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE … J Chao, CS Fuchs, K Shitara, J Tabernero, K Muro, E Van Cutsem, ... JAMA oncology 7 (6), 895-902, 2021 | 354 | 2021 |
| Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer K Shitara, JA Ajani, M Moehler, M Garrido, C Gallardo, L Shen, ... Nature 603 (7903), 942-948, 2022 | 333 | 2022 |
| Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised … CS Fuchs, K Shitara, M Di Bartolomeo, S Lonardi, SE Al-Batran, ... The Lancet Oncology 20 (3), 420-435, 2019 | 271 | 2019 |