| Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand R Ochoa-Sanchez, S Comai, B Lacoste, FR Bambico, ... Journal of Neuroscience 31 (50), 18439-18452, 2011 | 155 | 2011 |
| Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice J LoVerme, A Duranti, A Tontini, G Spadoni, M Mor, S Rivara, N Stella, ... Bioorganic & medicinal chemistry letters 19 (3), 639-643, 2009 | 137 | 2009 |
| 2-[N-Acylamino(C1−C3)alkyl]indoles as MT1 Melatonin Receptor Partial Agonists, Antagonists, and Putative Inverse Agonists G Spadoni, C Balsamini, A Bedini, G Diamantini, B Di Giacomo, A Tontini, ... Journal of medicinal chemistry 41 (19), 3624-3634, 1998 | 129 | 1998 |
| N-(Substituted-anilinoethyl)amides: Design, Synthesis, and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands S Rivara, A Lodola, M Mor, A Bedini, G Spadoni, V Lucini, M Pannacci, ... Journal of medicinal chemistry 50 (26), 6618-6626, 2007 | 105 | 2007 |
| Melatonin receptor ligands: Synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study M Mor, S Rivara, C Silva, F Bordi, PV Plazzi, G Spadoni, G Diamantini, ... Journal of medicinal chemistry 41 (20), 3831-3844, 1998 | 101 | 1998 |
| Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways M Lopez-Canul, E Palazzo, S Dominguez-Lopez, L Luongo, B Lacoste, ... Pain 156 (2), 305-317, 2015 | 100 | 2015 |
| Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models S Rivara, S Lorenzi, M Mor, PV Plazzi, G Spadoni, A Bedini, G Tarzia Journal of medicinal chemistry 48 (12), 4049-4060, 2005 | 93 | 2005 |
| 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity G Spadoni, B Stankov, A Duranti, G Biella, V Lucini, A Salvatori, ... Journal of medicinal chemistry 36 (25), 4069-4074, 1993 | 93 | 1993 |
| Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam R Ochoa-Sanchez, Q Rainer, S Comai, G Spadoni, A Bedini, S Rivara, ... Progress in neuro-psychopharmacology and biological psychiatry 39 (2), 318-325, 2012 | 92 | 2012 |
| Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study G Spadoni, C Balsamini, G Diamantini, B Di Giacomo, G Tarzia, M Mor, ... Journal of medicinal chemistry 40 (13), 1990-2002, 1997 | 92 | 1997 |
| Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells F Radogna, L Paternoster, MC Albertini, C Cerella, A Accorsi, A Bucchini, ... Journal of pineal research 43 (2), 154-162, 2007 | 89 | 2007 |
| Melatonin. M Mor, PV Plazzi, G Spadoni, G Tarzia Current medicinal chemistry 6 (6), 501-518, 1999 | 84 | 1999 |
| Melatonin receptor agonists: new options for insomnia and depression treatment G Spadoni, A Bedini, S Rivara, M Mor CNS neuroscience & therapeutics 17 (6), 733-741, 2011 | 83 | 2011 |
| Synthesis of tryptamine derivatives via a direct, one-pot reductive alkylation of indoles M Righi, F Topi, S Bartolucci, A Bedini, G Piersanti, G Spadoni The Journal of Organic Chemistry 77 (14), 6351-6357, 2012 | 79 | 2012 |
| Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders S Rivara, M Mor, A Bedini, G Spadoni, G Tarzia Current topics in medicinal chemistry 8 (11), 954-968, 2008 | 77 | 2008 |
| Iridium-catalyzed direct synthesis of tryptamine derivatives from indoles: exploiting N-protected β-amino alcohols as alkylating agents S Bartolucci, M Mari, A Bedini, G Piersanti, G Spadoni The Journal of Organic Chemistry 80 (6), 3217-3222, 2015 | 74 | 2015 |
| N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition D Piomelli, L Scalvini, Y Fotio, A Lodola, G Spadoni, G Tarzia, M Mor Journal of Medicinal Chemistry 63 (14), 7475-7490, 2020 | 71 | 2020 |
| 2-N-Acylaminoalkylindoles: Design and Quantitative Structure−Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists G Spadoni, C Balsamini, G Diamantini, A Tontini, G Tarzia, M Mor, ... Journal of medicinal chemistry 44 (18), 2900-2912, 2001 | 69 | 2001 |
| Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands M Mor, G Spadoni, B Di Giacomo, G Diamantini, A Bedini, G Tarzia, ... Bioorganic & medicinal chemistry 9 (4), 1045-1057, 2001 | 69 | 2001 |
| 1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: A new class of potent indole melatonin analogues G Tarzia, G Diamantini, B Di Giacomo, G Spadoni, D Esposti, R Nonno, ... Journal of medicinal chemistry 40 (13), 2003-2010, 1997 | 68 | 1997 |
Giorgio TarziaHonorary Professor, Medicinal Chemistry, University of UrbinoVerified email at uniurb.it
