| Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia LJ Russell, M Capasso, I Vater, T Akasaka, OA Bernard, MJ Calasanz, ... Blood, The Journal of the American Society of Hematology 114 (13), 2688-2698, 2009 | 613 | 2009 |
| Loci on 7p12. 2, 10q21. 2 and 14q11. 2 are associated with risk of childhood acute lymphoblastic leukemia E Papaemmanuil, FJ Hosking, J Vijayakrishnan, A Price, B Olver, ... Nature genetics 41 (9), 1006-1010, 2009 | 594 | 2009 |
| In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties C le Viseur, M Hotfilder, S Bomken, K Wilson, S Röttgers, A Schrauder, ... Cancer cell 14 (1), 47-58, 2008 | 357 | 2008 |
| Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk AL Sherborne, FJ Hosking, RB Prasad, R Kumar, R Koehler, ... Nature genetics 42 (6), 492-494, 2010 | 321 | 2010 |
| Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition J Irving, E Matheson, L Minto, H Blair, M Case, C Halsey, I Swidenbank, ... Blood 124 (23), 3420-3430, 2014 | 279 | 2014 |
| Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia V Frismantas, MP Dobay, A Rinaldi, J Tchinda, SH Dunn, J Kunz, ... Blood, The Journal of the American Society of Hematology 129 (11), e26-e37, 2017 | 241 | 2017 |
| A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity … S Sulong, AV Moorman, JAE Irving, JC Strefford, ZJ Konn, MC Case, ... Blood, The Journal of the American Society of Hematology 113 (1), 100-107, 2009 | 222 | 2009 |
| Common variation at 3q26. 2, 6p21. 33, 17p11. 2 and 22q13. 1 influences multiple myeloma risk D Chubb, N Weinhold, P Broderick, B Chen, DC Johnson, A Försti, ... Nature genetics 45 (10), 1221-1225, 2013 | 194 | 2013 |
| Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting T Knight, JAE Irving Frontiers in oncology 4, 160, 2014 | 187 | 2014 |
| Variation at 10p12. 2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype G Migliorini, B Fiege, FJ Hosking, Y Ma, R Kumar, AL Sherborne, ... Blood, the Journal of the American Society of Hematology 122 (19), 3298-3307, 2013 | 180 | 2013 |
| Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia M Case, E Matheson, L Minto, R Hassan, CJ Harrison, N Bown, S Bailey, ... Cancer research 68 (16), 6803-6809, 2008 | 171 | 2008 |
| Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia V Rand, H Parker, LJ Russell, C Schwab, H Ensor, J Irving, L Jones, ... Blood, The Journal of the American Society of Hematology 117 (25), 6848-6855, 2011 | 160 | 2011 |
| MMSET deregulation affects cell cycle progression and adhesion regulons in t (4; 14) myeloma plasma cells JLR Brito, B Walker, M Jenner, NJ Dickens, NJM Brown, FM Ross, ... haematologica 94 (1), 78, 2008 | 151 | 2008 |
| Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia JAE Irving, A Enshaei, CA Parker, R Sutton, RP Kuiper, A Erhorn, L Minto, ... Blood, The Journal of the American Society of Hematology 128 (7), 911-922, 2016 | 143 | 2016 |
| Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a … J Irving, J Jesson, P Virgo, M Case, L Minto, L Eyre, N Noel, U Johansson, ... haematologica 94 (6), 870, 2009 | 141 | 2009 |
| Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis JAE Irving, L Bloodworth, NP Bown, MC Case, LA Hogarth, AG Hall Cancer research 65 (8), 3053-3058, 2005 | 126 | 2005 |
| Acute B lymphoblastic leukaemia‐propagating cells are present at high frequency in diverse lymphoblast populations K Rehe, K Wilson, S Bomken, D Williamson, J Irving, ML den Boer, ... EMBO molecular medicine 5 (1), 38-51, 2013 | 110 | 2013 |
| International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia O Hrusak, V De Haas, J Stancikova, B Vakrmanova, I Janotova, ... Blood, The Journal of the American Society of Hematology 132 (3), 264-276, 2018 | 109 | 2018 |
| Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer Q An, SL Wright, ZJ Konn, E Matheson, L Minto, AV Moorman, H Parker, ... Proceedings of the National Academy of Sciences 105 (44), 17050-17054, 2008 | 94 | 2008 |
| Association of glucocorticoid receptor polymorphism A3669G in exon 9β with reduced central adiposity in women AA Syed, JAE Irving, CPF Redfern, AG Hall, NC Unwin, M White, ... Obesity 14 (5), 759-764, 2006 | 87 | 2006 |