| Structures and mechanisms of Nudix hydrolases AS Mildvan, Z Xia, HF Azurmendi, V Saraswat, PM Legler, MA Massiah, ... Archives of biochemistry and biophysics 433 (1), 129-143, 2005 | 354 | 2005 |
| Histidine affinity tags affect MSP142 structural stability and immunodominance in mice F Khan, PM Legler, RM Mease, EH Duncan, ES Bergmann‐Leitner, ... Biotechnology journal 7 (1), 133-147, 2012 | 103 | 2012 |
| Adjustment of Codon Usage Frequencies by Codon Harmonization Improves Protein Expression and Folding E Angov, PM Legler, RM Mease Methods in Molecular Biology 705, 1-13, 2011 | 94 | 2011 |
| Cellular and humoral immune effector mechanisms required for sterile protection against sporozoite challenge induced with the novel malaria vaccine candidate CelTOS ES Bergmann-Leitner, PM Legler, T Savranskaya, CF Ockenhouse, ... Vaccine 29 (35), 5940-5949, 2011 | 82 | 2011 |
| Kinetic, stereochemical, and structural effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase TK Harris, RM Czerwinski, WH Johnson, PM Legler, C Abeygunawardana, ... Biochemistry 38 (38), 12343-12357, 1999 | 75 | 1999 |
| Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody D Zabetakis, MA Olson, GP Anderson, PM Legler, ER Goldman PLoS One 9 (12), e115405, 2014 | 64 | 2014 |
| Probing the donor and acceptor substrate specificity of the γ-glutamyl transpeptidase X Hu, PM Legler, I Khavrutskii, A Scorpio, JR Compton, KL Robertson, ... Biochemistry 51 (6), 1199-1212, 2012 | 53 | 2012 |
| Effects of mutations of the active site arginine residues in 4-oxalocrotonate tautomerase on the p K a values of active site residues and on the pH dependence of catalysis RM Czerwinski, TK Harris, WH Johnson, PM Legler, JT Stivers, ... Biochemistry 38 (38), 12358-12366, 1999 | 52 | 1999 |
| Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease X Hu, JR Compton, DH Leary, MA Olson, MS Lee, J Cheung, W Ye, ... Biochemistry, 10.13140/RG.2.1.2883.6721, 2016 | 48 | 2016 |
| Structure of RiVax: a recombinant ricin vaccine PM Legler, RN Brey, JE Smallshaw, ES Vitetta, CB Millard Acta Crystallographica Section D: Biological Crystallography 67 (9), 826-830, 2011 | 45 | 2011 |
| Reexamination of human T cell lymphotropic virus (HTLV-I/II) prevalence D Zucker-Franklin, BA Pancake, M Marmor, PM Legler Proceedings of the National Academy of Sciences 94 (12), 6403-6407, 1997 | 42 | 1997 |
| Three-dimensional solution structure of the cytoplasmic B domain of the mannitol transporter IIMannitol of the Escherichia coli phosphotransferase system PM Legler, M Cai, A Peterkofsky, GM Clore Journal of Biological Chemistry 279 (37), 39115-39121, 2004 | 40 | 2004 |
| Structural Characterization and Reversal of the Natural Organophosphate Resistance of a D-Type Esterase, Saccharomyces cerevisiae S-Formylglutathione … PM Legler, D Kumaran, S Swaminathan, FW Studier, CB Millard Biochemistry 47 (36), 9592-9601, 2008 | 37 | 2008 |
| GDP-Mannose Mannosyl Hydrolase Catalyzes Nucleophilic Substitution at Carbon, Unlike All Other Nudix Hydrolases PM Legler, MA Massiah, MJ Bessman, AS Mildvan Biochemistry 39 (29), 8603-8608, 2000 | 34 | 2000 |
| Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus EM Morazzani, JR Compton, DH Leary, AV Berry, X Hu, JJ Marugan, ... Antiviral research 164, 106-122, 2019 | 33 | 2019 |
| Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen JR Compton, PM Legler, BV Clingan, MA Olson, CB Millard Proteins: Structure, Function, and Bioinformatics 79 (4), 1048-1060, 2011 | 31 | 2011 |
| Mutational, kinetic, and NMR studies of the mechanism of E. coli GDP-mannose mannosyl hydrolase, an unusual Nudix enzyme PM Legler, MA Massiah, AS Mildvan Biochemistry 41 (35), 10834-10848, 2002 | 31 | 2002 |
| The SARS-CoV-2 SSHHPS recognized by the papain-like protease ND Reynolds, NM Aceves, JL Liu, JR Compton, DH Leary, BT Freitas, ... ACS Infectious Diseases 7 (6), 1483-1502, 2021 | 29 | 2021 |
| 3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening X Hu, JR Compton, MDM AbdulHameed, CL Marchand, KL Robertson, ... Journal of medicinal chemistry 56 (13), 5275-5287, 2013 | 28 | 2013 |
| Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity N Punde, J Kooken, D Leary, PM Legler, E Angov Amb Express 9, 1-14, 2019 | 24 | 2019 |
L Mario AmzelJohns Hopkins University School of MedicineVerified email at jhmi.edu