| Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria KJ Wicht, S Mok, DA Fidock Annual review of microbiology 74 (1), 431-454, 2020 | 259 | 2020 |
| Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ... Nature communications 9 (1), 3314, 2018 | 241 | 2018 |
| Structure and drug resistance of the Plasmodium falciparum transporter PfCRT J Kim, YZ Tan, KJ Wicht, SK Erramilli, SK Dhingra, J Okombo, J Vendome, ... Nature 576 (7786), 315-320, 2019 | 189 | 2019 |
| Antimalarial drug discovery: Progress and approaches JL Siqueira-Neto, KJ Wicht, K Chibale, JN Burrows, DA Fidock, ... Nature Reviews Drug Discovery 22 (10), 807-826, 2023 | 88 | 2023 |
| Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity M Vanaerschot, JM Murithi, CFA Pasaje, S Ghidelli-Disse, L Dwomoh, ... Cell chemical biology 27 (7), 806-816. e8, 2020 | 76 | 2020 |
| In vitro antimalarial activity, β-haematin inhibition and structure–activity relationships in a series of quinoline triazoles MC Joshi, KJ Wicht, D Taylor, R Hunter, PJ Smith, TJ Egan European journal of medicinal chemistry 69, 338-347, 2013 | 73 | 2013 |
| Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo [3, 2-c] quinolines with various substituents at C2, C6 … N Wang, KJ Wicht, K Imai, M Wang, TA Ngoc, R Kiguchi, M Kaiser, ... Bioorganic & medicinal chemistry 22 (9), 2629-2642, 2014 | 72 | 2014 |
| Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2, 11-disubstituted indolo [2, 3-b] quinolines WJ Lu, KJ Wicht, L Wang, K Imai, ZW Mei, M Kaiser, IET El Sayed, ... European journal of medicinal chemistry 64, 498-511, 2013 | 69 | 2013 |
| Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity RD Sandlin, KY Fong, KJ Wicht, HM Carrell, TJ Egan, DW Wright International Journal for Parasitology: Drugs and Drug Resistance 4 (3), 316-325, 2014 | 57 | 2014 |
| Synthesis and evaluation of artesunate–indoloquinoline hybrids as antimalarial drug candidates N Wang, KJ Wicht, E Shaban, TA Ngoc, MQ Wang, I Hayashi, MI Hossain, ... MedChemComm 5 (7), 927-931, 2014 | 48 | 2014 |
| Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains M Chugh, C Scheurer, S Sax, E Bilsland, DA van Schalkwyk, KJ Wicht, ... Antimicrobial agents and chemotherapy 59 (2), 1110-1118, 2015 | 47 | 2015 |
| Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity R Raj, V Mehra, J Gut, PJ Rosenthal, KJ Wicht, TJ Egan, M Hopper, ... European Journal of Medicinal Chemistry 84, 425-432, 2014 | 46 | 2014 |
| Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum KJ Wicht, JM Combrinck, PJ Smith, R Hunter, TJ Egan Journal of medicinal chemistry 59 (13), 6512-6530, 2016 | 31 | 2016 |
| Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance JL Small-Saunders, LM Hagenah, KJ Wicht, SK Dhingra, I Deni, J Kim, ... PLoS Pathogens 18 (2), e1010278, 2022 | 30 | 2022 |
| Antimalarial benzoheterocyclic 4-aminoquinolines: structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies DSB Ongarora, N Strydom, K Wicht, M Njoroge, L Wiesner, TJ Egan, ... Bioorganic & medicinal chemistry 23 (17), 5419-5432, 2015 | 28 | 2015 |
| Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines: Structure–activity relationship study of 2, 11-and 9, 11-disubstituted 6 … N Wang, KJ Wicht, L Wang, WJ Lu, R Misumi, M Wang, AAA El Gokha, ... Chemical and pharmaceutical bulletin 61 (12), 1282-1290, 2013 | 26 | 2013 |
| Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials KJ Wicht, JL Small-Saunders, LM Hagenah, S Mok, DA Fidock The Journal of Infectious Diseases 226 (11), 2021-2029, 2022 | 25 | 2022 |
| Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine. Nat Commun 9: 3314 LS Ross, SK Dhingra, S Mok, T Yeo, KJ Wicht, K Kümpornsin, ... | 24 | 2018 |
| Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity KJ Wicht, JM Combrinck, PJ Smith, TJ Egan Bioorganic & medicinal chemistry 23 (16), 5210-5217, 2015 | 24 | 2015 |
| Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse … AT Nchinda, C Le Manach, T Paquet, D Gonzàlez Cabrera, KJ Wicht, ... Journal of medicinal chemistry 61 (9), 4213-4227, 2018 | 23 | 2018 |
