| Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain SE Marsh, AJ Walker, T Kamath, L Dissing-Olesen, TR Hammond, ... Nature neuroscience 25 (3), 306-316, 2022 | 263 | 2022 |
| PD-1 marks dysfunctional regulatory T cells in malignant gliomas DE Lowther, BA Goods, LE Lucca, BA Lerner, K Raddassi, D van Dijk, ... JCI insight 1 (5), 2016 | 262 | 2016 |
| Modulation of regulatory T cell function and stability by co-inhibitory receptors LE Lucca, M Dominguez-Villar Nature Reviews Immunology 20 (11), 680-693, 2020 | 178 | 2020 |
| TIGIT signaling restores suppressor function of Th1 Tregs LE Lucca, PP Axisa, ER Singer, NM Nolan, M Dominguez-Villar, ... JCI insight 4 (3), 2019 | 124 | 2019 |
| Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells LE Lucca, PP Axisa, B Lu, B Harnett, S Jessel, L Zhang, K Raddassi, ... Journal of Experimental Medicine 218 (4), e20200921, 2021 | 61 | 2021 |
| Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme BA Goods, AL Hernandez, DE Lowther, LE Lucca, BA Lerner, M Gunel, ... PLoS One 12 (9), e0181538, 2017 | 49 | 2017 |
| TCR-sequencing in cancer and autoimmunity: barcodes and beyond KE Pauken, KA Lagattuta, BY Lu, LE Lucca, AI Daud, DA Hafler, ... Trends in immunology 43 (3), 180-194, 2022 | 41 | 2022 |
| TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation AC Pichler, N Carrié, M Cuisinier, S Ghazali, A Voisin, PP Axisa, ... Immunity 56 (7), 1631-1648. e10, 2023 | 39 | 2023 |
| Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS LE Lucca, BA Lerner, C Park, D DeBartolo, B Harnett, VP Kumar, ... Neurology: Neuroimmunology & Neuroinflammation 7 (3), e712, 2020 | 36 | 2020 |
| The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity JR Kuchroo, DA Hafler, AH Sharpe, LE Lucca Science immunology 6 (65), eabf4034, 2021 | 34 | 2021 |
| In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS A Ramadan, LE Lucca, N Carrié, S Desbois, PP Axisa, M Hayder, J Bauer, ... Brain 139 (5), 1433-1446, 2016 | 19 | 2016 |
| Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice LE Lucca, S Desbois, A Ramadan, A Ben-Nun, M Eisenstein, N Carrié, ... The Journal of Immunology 193 (7), 3267-3277, 2014 | 19 | 2014 |
| Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment LE Lucca, DA Hafler The Journal of Clinical Investigation 127 (4), 1218-1220, 2017 | 18 | 2017 |
| Co‐inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma LE Lucca, DA Hafler Immunological reviews 276 (1), 9-25, 2017 | 18 | 2017 |
| Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4+ T cells specific for both a myelin and a neuronal self‐antigen in mice LE Lucca, PP Axisa, M Aloulou, C Perals, A Ramadan, P Rufas, ... European Journal of Immunology 46 (9), 2247-2259, 2016 | 17 | 2016 |
| Thymic-specific serine protease limits central tolerance and exacerbates experimental autoimmune encephalomyelitis L Serre, M Girard, A Ramadan, P Menut, N Rouquié, LE Lucca, ... The Journal of Immunology 199 (11), 3748-3756, 2017 | 16 | 2017 |
| Clinical significance of PDCD4 in melanoma by subcellular expression and in tumor-associated immune cells TT Tran, CK Rane, CR Zito, SA Weiss, S Jessel, L Lucca, BY Lu, VO Oria, ... Cancers 13 (5), 1049, 2021 | 14 | 2021 |
| T cell dysfunction in glioblastoma: a barrier and an opportunity for the development of successful immunotherapies JA Jansen, A Omuro, LE Lucca Current opinion in neurology 34 (6), 827-833, 2021 | 11 | 2021 |
| A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells PP Axisa, TM Yoshida, LE Lucca, HG Kasler, MR Lincoln, GH Pham, ... Science Translational Medicine 14 (675), eabl3651, 2022 | 10 | 2022 |
| Sodium-activated macrophages: the salt mine expands LE Lucca, DA Hafler Cell Research 25 (8), 885-886, 2015 | 9 | 2015 |
David HaflerProfessor of Neurology and Immunobiology, Yale UniversityVerified email at yale.edu