| Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response MM Szewczyk, Y Ishikawa, S Organ, N Sakai, F Li, L Halabelian, S Ackloo, ... Nature communications 11 (1), 2396, 2020 | 98 | 2020 |
| Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities RJ Harding, Y Tong Acta Pharmacologica Sinica 39 (5), 754-769, 2018 | 91 | 2018 |
| Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules S Johnson, L Tan, S van der Veen, J Caesar, E Goicoechea De Jorge, ... PLoS pathogens 8 (10), e1002981, 2012 | 76 | 2012 |
| Identification and structure–activity relationship of HDAC6 zinc-finger ubiquitin binding domain inhibitors R Ferreira de Freitas, RJ Harding, I Franzoni, M Ravichandran, MK Mann, ... Journal of Medicinal Chemistry 61 (10), 4517-4527, 2018 | 60 | 2018 |
| Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1 RJ Harding, JC Deme, JF Hevler, S Tamara, A Lemak, JP Cantle, ... Communications Biology 4 (1), 1374, 2021 | 43 | 2021 |
| Small molecule antagonists of the interaction between the histone deacetylase 6 zinc-finger domain and ubiquitin RJ Harding, R Ferreira de Freitas, P Collins, I Franzoni, M Ravichandran, ... Journal of Medicinal Chemistry 60 (21), 9090-9096, 2017 | 39 | 2017 |
| The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear Q Zhang, Z Wang, F Hou, R Harding, X Huang, A Dong, JR Walker, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1861 (1), 3095-3105, 2017 | 36 | 2017 |
| Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems RJ Harding, P Loppnau, S Ackloo, A Lemak, A Hutchinson, B Hunt, ... Journal of Biological Chemistry 294 (17), 6986-7001, 2019 | 35 | 2019 |
| Structural basis of the recruitment of ubiquitin-specific protease USP15 by spliceosome recycling factor SART3 Q Zhang, R Harding, F Hou, A Dong, JR Walker, J Bteich, Y Tong Journal of Biological Chemistry 291 (33), 17283-17292, 2016 | 33 | 2016 |
| Open laboratory notebooks: good for science, good for society, good for scientists M Schapira, TOLN Consortium, RJ Harding F1000Research 8 (87), https://doi.org/10.12688/f1000research.1, 2019 | 30 | 2019 |
| Foundations for open scholarship strategy development J Tennant, J Beamer, J Bosman, B Brembs, NC Chung, G Clement, ... MetaArXiv, 2019 | 28 | 2019 |
| Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis H Zhang, B Zhou, S Qin, J Xu, R Harding, W Tempel, V Nayak, Y Li, ... Genes & Development 32 (5-6), 341-346, 2018 | 19 | 2018 |
| Structure–Activity Relationship of USP5 Inhibitors MK Mann, CA Zepeda-Velázquez, H González-Álvarez, A Dong, T Kiyota, ... Journal of medicinal chemistry 64 (20), 15017-15036, 2021 | 17 | 2021 |
| Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain MS Mandeep K. Mann, Ivan Franzoni, Renato Ferreira de Freitas, Wolfram ... Journal of Medicinal Chemistry 62 (22), 10144-10155, 2019 | 16 | 2019 |
| Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability T Gall-Duncan, J Luo, CM Jurkovic, LA Fischer, K Fujita, AL Deshmukh, ... Cell 186 (22), 4898-4919. e25, 2023 | 14* | 2023 |
| Open notebook science can maximize impact for rare disease projects RJ Harding PLOS Biology 17 (1), e3000120, 2019 | 13 | 2019 |
| The Canadian Open Neuroscience Platform—An open science framework for the neuroscience community RJ Harding, P Bermudez, A Bernier, M Beauvais, P Bellec, S Hill, ... PLOS Computational Biology 19 (7), e1011230, 2023 | 11 | 2023 |
| Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6 RJ Harding, I Franzoni, MK Mann, MM Szewczyk, B Mirabi, ... Journal of Medicinal Chemistry 66 (15), 10273-10288, 2023 | 7 | 2023 |
| CACHE Challenge# 1: targeting the WDR domain of LRRK2, a Parkinson’s Disease associated protein F Li, S Ackloo, CH Arrowsmith, F Ban, CJ Barden, H Beck, J Beránek, ... Journal of Chemical Information and Modeling 64 (22), 8521-8536, 2024 | 6 | 2024 |
| Detection of antibodies against the huntingtin protein in human plasma HL Denis, M Alpaugh, CP Alvarez, A Fenyi, RA Barker, S Chouinard, ... Cellular and Molecular Life Sciences 80 (2), 45, 2023 | 5 | 2023 |
