| The cellular thermal shift assay for evaluating drug target interactions in cells R Jafari, H Almqvist, H Axelsson, M Ignatushchenko, T Lundbäck, ... Nature protocols 9 (9), 2100-2122, 2014 | 1263 | 2014 |
| MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ... Nature 508 (7495), 215-221, 2014 | 565 | 2014 |
| Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus H Baumann, S Knapp, T Lundbäck, R Ladenstein, T Härd Nature structural biology 1 (11), 808-819, 1994 | 220 | 1994 |
| CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ... Nature communications 7 (1), 11040, 2016 | 168 | 2016 |
| Oligomerization of the chromatin‐structuring protein H‐NS CP Smyth, T Lundbäck, D Renzoni, G Siligardi, R Beavil, M Layton, ... Molecular microbiology 36 (4), 962-972, 2000 | 131 | 2000 |
| Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies N Herold, SG Rudd, L Ljungblad, K Sanjiv, IH Myrberg, CBJ Paulin, ... Nature medicine 23 (2), 256-263, 2017 | 130 | 2017 |
| N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors T Barf, F Lehmann, K Hammer, S Haile, E Axen, C Medina, J Uppenberg, ... Bioorganic & medicinal chemistry letters 19 (6), 1745-1748, 2009 | 115 | 2009 |
| Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus T Lundbäck, H Hansson, S Knapp, R Ladenstein, T Härd Journal of molecular biology 276 (4), 775-786, 1998 | 108 | 1998 |
| Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target F Lehmann, S Haile, E Axen, C Medina, J Uppenberg, S Svensson, ... Bioorganic & medicinal chemistry letters 14 (17), 4445-4448, 2004 | 102 | 2004 |
| Sequence-specific DNA-binding dominated by dehydration. T Lundbäck, T Härd Proceedings of the National Academy of Sciences 93 (10), 4754-4759, 1996 | 93 | 1996 |
| Prediction of intracellular exposure bridges the gap between target-and cell-based drug discovery A Mateus, LJ Gordon, GJ Wayne, H Almqvist, H Axelsson, ... Proceedings of the National Academy of Sciences 114 (30), E6231-E6239, 2017 | 90 | 2017 |
| Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells BDG Page, NCK Valerie, RHG Wright, O Wallner, R Isaksson, M Carter, ... Nature communications 9 (1), 250, 2018 | 87 | 2018 |
| Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors R Ringom, E Axen, J Uppenberg, T Lundbäck, L Rondahl, T Barf Bioorganic & medicinal chemistry letters 14 (17), 4449-4452, 2004 | 86 | 2004 |
| Structure-based screening as applied to human FABP4: a highly efficient alternative to HTS for hit generation MJP van Dongen, J Uppenberg, S Svensson, T Lundbäck, T Åkerud, ... Journal of the American Chemical Society 124 (40), 11874-11880, 2002 | 77 | 2002 |
| CETSA beyond soluble targets: a broad application to multipass transmembrane proteins A Kawatkar, M Schefter, NO Hermansson, A Snijder, N Dekker, DG Brown, ... ACS chemical biology 14 (9), 1913-1920, 2019 | 76 | 2019 |
| Thermodynamics of sequence-specific protein-DNA interactions T Härd, T Lundbäck Biophysical chemistry 62 (1-3), 121-139, 1996 | 76 | 1996 |
| Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis K Brunner, S Maric, RS Reshma, H Almqvist, B Seashore-Ludlow, ... Journal of Medicinal Chemistry 59 (14), 6848-6859, 2016 | 64 | 2016 |
| Structure–activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis SK Vodnala, T Lundbäck, E Yeheskieli, B Sjöberg, AL Gustavsson, ... Journal of medicinal chemistry 56 (24), 9861-9873, 2013 | 63 | 2013 |
| Thermodynamics of the glucocorticoid receptor-DNA interaction: binding of wild-type GR DBD to different response elements T Lundbäck, C Cairns, JÅ Gustafsson, J Carlstedt-Duke, T Härd Biochemistry 32 (19), 5074-5082, 1993 | 62 | 1993 |
| Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding JF Chang, K Phillips, T LundbaÈck, M Gstaiger, JE Ladbury, B Luisi Journal of molecular biology 288 (5), 941-952, 1999 | 58 | 1999 |
Torleif HärdProfessor of Structural Molecular Biology, SLU, UppsalaVerified email at slu.se
