| Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ... Neuron 17 (5), 1005-1013, 1996 | 2143 | 1996 |
| Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ... Human molecular genetics 13 (2), 159-170, 2004 | 1842 | 2004 |
| An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ... Neuron 14 (6), 1105-1116, 1995 | 1762 | 1995 |
| ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions LI Bruijn, MW Becher, MK Lee, KL Anderson, NA Jenkins, NG Copeland, ... neuron 18 (2), 327-338, 1997 | 1655 | 1997 |
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo G Thinakaran, DR Borchelt, MK Lee, HH Slunt, L Spitzer, G Kim, ... Neuron 17 (1), 181-190, 1996 | 1358 | 1996 |
| Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins DR Borchelt, T Ratovitski, J Van Lare, MK Lee, V Gonzales, NA Jenkins, ... Neuron 19 (4), 939-945, 1997 | 1352 | 1997 |
| Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis VM Nemani, W Lu, V Berge, K Nakamura, B Onoa, MK Lee, FA Chaudhry, ... Neuron 65 (1), 66-79, 2010 | 1292 | 2010 |
| Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→ Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice MK Lee, W Stirling, Y Xu, X Xu, D Qui, AS Mandir, TM Dawson, ... Proceedings of the National Academy of Sciences 99 (13), 8968-8973, 2002 | 994 | 2002 |
| Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis M Wiedau-Pazos, JJ Goto, S Rabizadeh, EB Gralla, JA Roe, MK Lee, ... Science 271 (5248), 515-518, 1996 | 952 | 1996 |
| Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death LJ Martin, Y Pan, AC Price, W Sterling, NG Copeland, NA Jenkins, ... Journal of Neuroscience 26 (1), 41-50, 2006 | 871 | 2006 |
| Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ... Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994 | 814 | 1994 |
| Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform T Ishihara, M Hong, B Zhang, Y Nakagawa, MK Lee, JQ Trojanowski, ... Neuron 24 (3), 751-762, 1999 | 720 | 1999 |
| The expression and posttranslational modification of a neuron‐specific β‐tubulin isotype during chick embryogenesis MK Lee, JB Tuttle, LI Rebhun, DW Cleveland, A Frankfurter Cell motility and the cytoskeleton 17 (2), 118-132, 1990 | 707 | 1990 |
| Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations W Li, N West, E Colla, O Pletnikova, JC Troncoso, L Marsh, TM Dawson, ... Proceedings of the National Academy of Sciences 102 (6), 2162-2167, 2005 | 587 | 2005 |
| Neuronal intermediate filaments MK Lee, DW Cleveland Annual review of neuroscience 19 (1), 187-217, 1996 | 578 | 1996 |
| Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases JMM Tan, ESP Wong, DS Kirkpatrick, O Pletnikova, HS Ko, SP Tay, ... Human molecular genetics 17 (3), 431-439, 2008 | 568 | 2008 |
| Assessment of normal and mutant human presenilin function in Caenorhabditis elegans D Levitan, TG Doyle, D Brousseau, MK Lee, G Thinakaran, HH Slunt, ... Proceedings of the National Academy of Sciences 93 (25), 14940-14944, 1996 | 490 | 1996 |
| Neurofilaments are obligate heteropolymers in vivo MK Lee, Z Xu, PC Wong, DW Cleveland The Journal of cell biology 122 (6), 1337-1350, 1993 | 476 | 1993 |
| Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2 D Ramonet, JPL Daher, BM Lin, K Stafa, J Kim, R Banerjee, M Westerlund, ... PloS one 6 (4), e18568, 2011 | 474 | 2011 |
| The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine CS Arnold, GVW Johnson, RN Cole, DLY Dong, M Lee, GW Hart Journal of Biological Chemistry 271 (46), 28741-28744, 1996 | 472 | 1996 |