| Unresponsiveness of colon cancer to BRAF (V600E) inhibition through feedback activation of EGFR A Prahallad, C Sun, S Huang, F Di Nicolantonio, R Salazar, D Zecchin, ... Nature 483 (7387), 100-103, 2012 | 2268 | 2012 |
| Reversible and adaptive resistance to BRAF (V600E) inhibition in melanoma C Sun, L Wang, S Huang, GJJE Heynen, A Prahallad, C Robert, ... Nature 508 (7494), 118-122, 2014 | 940 | 2014 |
| MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling S Huang, M Hölzel, T Knijnenburg, A Schlicker, P Roepman, U McDermott, ... Cell 151 (5), 937-950, 2012 | 503 | 2012 |
| Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3 C Sun, S Hobor, A Bertotti, D Zecchin, S Huang, F Galimi, F Cottino, ... Cell reports 7 (1), 86-93, 2014 | 360 | 2014 |
| NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome M Hölzel, S Huang, J Koster, I Øra, A Lakeman, H Caron, W Nijkamp, ... Cell 142 (2), 218-229, 2010 | 233 | 2010 |
| SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer Y Xue, B Meehan, Z Fu, XQD Wang, PO Fiset, R Rieker, C Levins, T Kong, ... Nature communications 10 (1), 557, 2019 | 179 | 2019 |
| Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics JM Scharf, MG Endrizzi, A Wetter, S Huang, TG Thompson, K Zerres, ... Nature genetics 20 (1), 83-86, 1998 | 174 | 1998 |
| ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome S Huang, J Laoukili, MT Epping, J Koster, M Hölzel, BA Westerman, ... Cancer cell 15 (4), 328-340, 2009 | 157 | 2009 |
| CD44 promotes PD-L1 expression and its tumor-intrinsic function in breast and lung cancers T Kong, R Ahn, K Yang, X Zhu, Z Fu, G Morin, R Bramley, NC Cliffe, Y Xue, ... Cancer research 80 (3), 444-457, 2020 | 138 | 2020 |
| Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress K Rajesh, J Krishnamoorthy, U Kazimierczak, C Tenkerian, AI Papadakis, ... Cell death & disease 6 (1), e1591-e1591, 2015 | 137 | 2015 |
| Expression of DRD2 is increased in human pancreatic ductal adenocarcinoma and inhibitors slow tumor growth in mice P Jandaghi, HS Najafabadi, AS Bauer, AI Papadakis, M Fassan, A Hall, ... Gastroenterology 151 (6), 1218-1231, 2016 | 134 | 2016 |
| Small-cell carcinoma of the ovary, hypercalcemic type–genetics, new treatment targets, and current management guidelines M Tischkowitz, S Huang, S Banerjee, J Hague, WPD Hendricks, ... Clinical Cancer Research 26 (15), 3908-3917, 2020 | 133 | 2020 |
| CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary Y Xue, B Meehan, E Macdonald, S Venneti, XQD Wang, L Witkowski, ... Nature communications 10 (1), 558, 2019 | 130 | 2019 |
| Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway M Drosten, EYM Sum, CG Lechuga, L Simón-Carrasco, HKC Jacob, ... Proceedings of the National Academy of Sciences 111 (42), 15155-15160, 2014 | 107 | 2014 |
| MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma Y Zhan, J Guo, W Yang, C Goncalves, T Rzymski, A Dreas, E Żyłkiewicz, ... The Journal of clinical investigation 127 (11), 4179-4192, 2017 | 79 | 2017 |
| A Systematic High-Throughput Screen of a Yeast Deletion Collection for Mutants Defective in PHO5 Regulation S Huang, EK O'Shea Genetics 169 (4), 1859-1871, 2005 | 76 | 2005 |
| SWI/SNF-compromised cancers are susceptible to bromodomain inhibitors T Shorstova, M Marques, J Su, J Johnston, CL Kleinman, N Hamel, ... Cancer research 79 (10), 2761-2774, 2019 | 72 | 2019 |
| SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer AI Papadakis, C Sun, TA Knijnenburg, Y Xue, W Grernrum, M Hölzel, ... Cell research 25 (4), 445-458, 2015 | 70 | 2015 |
| A general framework for interrogation of mRNA stability programs identifies RNA-binding proteins that govern cancer transcriptomes G Perron, P Jandaghi, S Solanki, M Safisamghabadi, C Storoz, ... Cell Reports 23 (6), 1639-1650, 2018 | 67 | 2018 |
| Methods and means for predicting resistance to anti-cancer treatment R Bernards, P Roepman, S Huang US Patent App. 14/434,474, 2015 | 65 | 2015 |
Rene BernardsNetherlands Cancer InstituteVerified email at nki.nl