| Large-scale analysis of the human and mouse transcriptomes AI Su, MP Cooke, KA Ching, Y Hakak, JR Walker, T Wiltshire, AP Orth, ... Proceedings of the National Academy of Sciences 99 (7), 4465-4470, 2002 | 1835 | 2002 |
| Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication R König, Y Zhou, D Elleder, TL Diamond, GMC Bonamy, JT Irelan, ... Cell 135 (1), 49-60, 2008 | 1203 | 2008 |
| Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling W Li, MH Bengtson, A Ulbrich, A Matsuda, VA Reddy, A Orth, SK Chanda, ... PloS one 3 (1), e1487, 2008 | 1005 | 2008 |
| Human host factors required for influenza virus replication R König, S Stertz, Y Zhou, A Inoue, HH Hoffmann, S Bhattacharyya, ... Nature 463 (7282), 813-817, 2010 | 991 | 2010 |
| A strategy for probing the function of noncoding RNAs finds a repressor of NFAT AT Willingham, AP Orth, S Batalov, EC Peters, BG Wen, P Aza-Blanc, ... Science 309 (5740), 1570-1573, 2005 | 877 | 2005 |
| SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel Z Qiu, AE Dubin, J Mathur, B Tu, K Reddy, LJ Miraglia, J Reinhardt, ... Cell 157 (2), 447-458, 2014 | 586 | 2014 |
| Co-regulatory networks of human serum proteins link genetics to disease V Emilsson, M Ilkov, JR Lamb, N Finkel, EF Gudmundsson, R Pitts, ... Science 361 (6404), 769-773, 2018 | 528 | 2018 |
| Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells V Iourgenko, W Zhang, C Mickanin, I Daly, C Jiang, JM Hexham, AP Orth, ... Proceedings of the National Academy of Sciences 100 (21), 12147-12152, 2003 | 438 | 2003 |
| A probability-based approach for the analysis of large-scale RNAi screens R König, C Chiang, BP Tu, SF Yan, PD DeJesus, A Romero, T Bergauer, ... Nature methods 4 (10), 847-849, 2007 | 385 | 2007 |
| An approach to genomewide screens of expressed small interfering RNAs in mammalian cells L Zheng, J Liu, S Batalov, D Zhou, A Orth, S Ding, PG Schultz Proceedings of the National Academy of Sciences 101 (1), 135-140, 2004 | 306 | 2004 |
| High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol M Bandell, AE Dubin, MJ Petrus, A Orth, J Mathur, SW Hwang, ... Nature neuroscience 9 (4), 493-500, 2006 | 300 | 2006 |
| GPR68 senses flow and is essential for vascular physiology J Xu, J Mathur, E Vessières, S Hammack, K Nonomura, J Favre, ... Cell 173 (3), 762-775. e16, 2018 | 280 | 2018 |
| Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression H Teo, S Ghosh, H Luesch, A Ghosh, ET Wong, N Malik, A Orth, ... Nature cell biology 12 (8), 758-767, 2010 | 247 | 2010 |
| Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets SR Horman, MM Janas, C Litterst, B Wang, IJ MacRae, MJ Sever, ... Molecular cell 50 (3), 356-367, 2013 | 194 | 2013 |
| A functional genomics approach to the mode of action of apratoxin A H Luesch, SK Chanda, RM Raya, PD DeJesus, AP Orth, JR Walker, ... Nature chemical biology 2 (3), 158-167, 2006 | 194 | 2006 |
| An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation H Wurdak, S Zhu, A Romero, M Lorger, J Watson, C Chiang, J Zhang, ... Cell stem cell 6 (1), 37-47, 2010 | 186 | 2010 |
| Genome-wide functional analysis of human cell-cycle regulators M Mukherji, R Bell, L Supekova, Y Wang, AP Orth, S Batalov, L Miraglia, ... Proceedings of the National Academy of Sciences 103 (40), 14819-14824, 2006 | 159 | 2006 |
| The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα A Britschgi, S Duss, S Kim, JP Couto, H Brinkhaus, S Koren, D De Silva, ... Nature 541 (7638), 541-545, 2017 | 141 | 2017 |
| Structure-guided combination therapy to potently improve the function of mutant CFTRs G Veit, H Xu, E Dreano, RG Avramescu, M Bagdany, LK Beitel, A Roldan, ... Nature medicine 24 (11), 1732-1742, 2018 | 139 | 2018 |
| A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway AL Amelio, LJ Miraglia, JJ Conkright, BA Mercer, S Batalov, V Cavett, ... Proceedings of the National Academy of Sciences 104 (51), 20314-20319, 2007 | 136 | 2007 |
