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Yogesh Dhungana
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Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
J Wei, L Long, W Zheng, Y Dhungana, SA Lim, C Guy, Y Wang, YD Wang, ...
Nature 576 (7787), 471-476, 2019
3432019
Lipid signalling enforces functional specialization of Treg cells in tumours
SA Lim, J Wei, TLM Nguyen, H Shi, W Su, G Palacios, Y Dhungana, ...
Nature 591 (7849), 306-311, 2021
2882021
Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells
X Du, J Wen, Y Wang, PWF Karmaus, A Khatamian, H Tan, Y Li, C Guy, ...
Nature 558 (7708), 141-145, 2018
1852018
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
PWF Karmaus, X Chen, SA Lim, AA Herrada, TLM Nguyen, B Xu, ...
Nature 565 (7737), 101-105, 2019
1812019
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis
NM Chapman, H Zeng, TLM Nguyen, Y Wang, P Vogel, Y Dhungana, ...
Nature communications 9 (1), 2095, 2018
1602018
cBAF complex components and MYC cooperate early in CD8+ T cell fate
A Guo, H Huang, Z Zhu, MJ Chen, H Shi, S Yuan, P Sharma, JP Connelly, ...
Nature 607 (7917), 135-141, 2022
1212022
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
C Guo, Z You, H Shi, Y Sun, X Du, G Palacios, C Guy, S Yuan, ...
Nature 620 (7972), 200-208, 2023
1162023
Hippo kinases Mst1 and Mst2 sense and amplify IL-2R-STAT5 signaling in regulatory T cells to establish stable regulatory activity
H Shi, C Liu, H Tan, Y Li, TLM Nguyen, Y Dhungana, C Guy, P Vogel, ...
Immunity 49 (5), 899-914. e6, 2018
1082018
Amino acids license kinase mTORC1 activity and Treg cell function via small G proteins Rag and Rheb
H Shi, NM Chapman, J Wen, C Guy, L Long, Y Dhungana, S Rankin, ...
Immunity 51 (6), 1012-1027. e7, 2019
1032019
Novel specialized cell state and spatial compartments within the germinal center
DE Kennedy, MK Okoreeh, M Maienschein-Cline, J Ai, M Veselits, ...
Nature immunology 21 (6), 660-670, 2020
1002020
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine
G Fu, CS Guy, NM Chapman, G Palacios, J Wei, P Zhou, L Long, ...
Nature 595 (7869), 724-729, 2021
982021
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions
H Huang, P Zhou, J Wei, L Long, H Shi, Y Dhungana, NM Chapman, G Fu, ...
Cell 184 (5), 1245-1261. e21, 2021
952021
Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells
K Yang, DB Blanco, X Chen, P Dash, G Neale, C Rosencrance, J Easton, ...
Science immunology 3 (25), eaas9818, 2018
782018
Homeostasis and transitional activation of regulatory T cells require c-Myc
J Saravia, H Zeng, Y Dhungana, D Bastardo Blanco, TLM Nguyen, ...
Science advances 6 (1), eaaw6443, 2020
732020
CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity
L Long, J Wei, SA Lim, JL Raynor, H Shi, JP Connelly, H Wang, C Guy, ...
Nature 600 (7888), 308-313, 2021
692021
LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity
Y Wang, X Du, J Wei, L Long, H Tan, C Guy, Y Dhungana, C Qian, ...
Cell research 29 (5), 391-405, 2019
682019
Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR–T-cell responses against ALL
W Zheng, J Wei, CC Zebley, LL Jones, Y Dhungana, YD Wang, J Mavuluri, ...
Blood, The Journal of the American Society of Hematology 138 (2), 122-135, 2021
512021
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis
PWF Karmaus, AA Herrada, C Guy, G Neale, Y Dhungana, L Long, ...
Journal of Experimental Medicine 214 (9), 2629-2647, 2017
512017
Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7–driven B lymphopoiesis
H Zeng, M Yu, H Tan, Y Li, W Su, H Shi, Y Dhungana, C Guy, G Neale, ...
Science Advances 4 (1), eaar5701, 2018
432018
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
N Baran, A Lodi, Y Dhungana, S Herbrich, M Collins, S Sweeney, ...
Nature communications 13 (1), 2801, 2022
422022
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