| Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life SBJ Kan, RD Lewis, K Chen, FH Arnold Science 354 (6315), 1048-1051, 2016 | 624 | 2016 |
| Machine learning-assisted directed protein evolution with combinatorial libraries Z Wu, SBJ Kan, RD Lewis, BJ Wittmann, FH Arnold Proceedings of the National Academy of Sciences 116 (18), 8852-8858, 2019 | 563 | 2019 |
| Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes AM Knight, SBJ Kan, RD Lewis, OF Brandenberg, K Chen, FH Arnold ACS Central Science 4 (3), 372-377, 2018 | 142 | 2018 |
| Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase RD Lewis, M Garcia-Borràs, MJ Chalkley, AR Buller, KN Houk, SBJ Kan, ... Proceedings of the National Academy of Sciences 115 (28), 7308-7313, 2018 | 126 | 2018 |
| Highly stereoselective biocatalytic synthesis of key cyclopropane intermediate to ticagrelor KE Hernandez, H Renata, RD Lewis, SBJ Kan, C Zhang, J Forte, ... ACS catalysis 6 (11), 7810-7813, 2016 | 96 | 2016 |
| The evolving nature of biocatalysis in pharmaceutical research and development SP France, RD Lewis, CA Martinez JACS Au 3 (3), 715-735, 2023 | 84 | 2023 |
| Identification of mechanism-based inactivation in P450-catalyzed cyclopropanation facilitates engineering of improved enzymes H Renata, RD Lewis, MJ Sweredoski, A Moradian, S Hess, ZJ Wang, ... Journal of the American Chemical Society 138 (38), 12527-12533, 2016 | 79 | 2016 |
| Origin and Control of Chemoselectivity in Cytochrome c Catalyzed Carbene Transfer into Si–H and N–H bonds M Garcia-Borràs, SBJ Kan, RD Lewis, A Tang, G Jimenez-Osés, ... Journal of the American Chemical Society 143 (18), 7114-7123, 2021 | 47 | 2021 |
| Ancestral sequence reconstruction enhances gene mining efforts for industrial ene reductases by expanding enzyme panels with thermostable catalysts J Livada, AM Vargas, CA Martinez, RD Lewis ACS Catalysis 13 (4), 2576-2585, 2023 | 32 | 2023 |
| The Single‐Component Flavin Reductase/Flavin‐Dependent Halogenase AetF is a Versatile Catalyst for Selective Bromination and Iodination of Arenes and Olefins Y Jiang, HM Snodgrass, YS Zubi, CV Roof, Y Guan, D Mondal, ... Angewandte Chemie 134 (51), e202214610, 2022 | 29 | 2022 |
| Emerging technologies for biocatalysis in the pharmaceutical industry RD Lewis, SP France, CA Martinez ACS Catalysis 13 (8), 5571-5577, 2023 | 26 | 2023 |
| A regulated, ubiquitin-independent degron in IκBα KT Fortmann, RD Lewis, KA Ngo, R Fagerlund, A Hoffmann Journal of molecular biology 427 (17), 2748-2756, 2015 | 26 | 2015 |
| A reductive aminase switches to imine reductase mode for a bulky amine substrate AK Gilio, TW Thorpe, A Heyam, MR Petchey, B Pogranyi, SP France, ... ACS catalysis 13 (3), 1669-1677, 2023 | 17 | 2023 |
| Engineering of a Reductive Aminase to Enable the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor J Steflik, A Gilio, M Burns, G Grogan, R Kumar, R Lewis, C Martinez ACS Catalysis 13 (15), 10065-10075, 2023 | 8 | 2023 |
| Evolution and characterization of carbene transferases for cyclopropanation and carbon–silicon bond formation RDR Lewis California Institute of Technology, 2019 | 2 | 2019 |
| Cytochrome C protein variants for catalyzing carbon-silicon bond formation SBJ Kan, RD Lewis, K Chen, FH Arnold US Patent 10,093,906, 2018 | 2 | 2018 |
| Heme Protein Catalysts for Carbon-Silicon Bond Formation In Vitro and In Vivo SBJ Kan, RD Lewis, K Chen, FH Arnold US Patent App. 15/422,360, 2017 | 2 | 2017 |
| Development of the Synthetic Route to PF-06878031 Part 2: Amide Reduction Route MS Brown, J Buck, DJ Critcher, AM Derrick, H Fenton, SJ Fussell, ... Organic Process Research & Development, 2024 | 1 | 2024 |
| Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor FH Arnold, H Renata, JA McIntosh, RD Lewis, SBJ Kan, K Hernandez, ... US Patent App. 15/576,243, 2018 | 1 | 2018 |
| Ancestral Sequence Reconstruction Meets Machine Learning: Ene Reductase Thermostabilization Yields Enzymes with Improved Reactivity Profiles CK Brennan, J Livada, CA Martinez, RD Lewis ACS Catalysis 14 (23), 17893-17900, 2024 | | 2024 |
