| CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ... Nature communications 8 (1), 14432, 2017 | 550 | 2017 |
| Targeting mitosis in cancer: emerging strategies C Dominguez-Brauer, KL Thu, JM Mason, H Blaser, MR Bray, TW Mak Molecular cell 60 (4), 524-536, 2015 | 517 | 2015 |
| Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell–like properties in cancer cells K Shien, S Toyooka, H Yamamoto, J Soh, M Jida, KL Thu, S Hashida, ... Cancer research 73 (10), 3051-3061, 2013 | 303 | 2013 |
| The detection and implication of genome instability in cancer L Pikor, K Thu, E Vucic, W Lam Cancer and Metastasis Reviews 32, 341-352, 2013 | 233 | 2013 |
| Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2 S Inoue, WY Li, A Tseng, I Beerman, AJ Elia, SC Bendall, F Lemonnier, ... Cancer cell 30 (2), 337-348, 2016 | 225 | 2016 |
| Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology VD Martinez, EA Vucic, KL Thu, R Hubaux, KSS Enfield, LA Pikor, ... Scientific reports 5 (1), 10423, 2015 | 192 | 2015 |
| Targeting the cell cycle in breast cancer: towards the next phase KL Thu, I Soria-Bretones, TW Mak, DW Cescon Cell Cycle 17 (15), 1871-1885, 2018 | 181 | 2018 |
| DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways EA Vucic, R Chari, KL Thu, IM Wilson, AM Cotton, JY Kennett, M Zhang, ... American journal of respiratory cell and molecular biology 50 (5), 912-922, 2014 | 163 | 2014 |
| Polycomb-mediated silencing in neuroendocrine prostate cancer PL Clermont, D Lin, F Crea, R Wu, H Xue, Y Wang, KL Thu, WL Lam, ... Clinical epigenetics 7, 1-13, 2015 | 155 | 2015 |
| Translating cancer ‘omics’ to improved outcomes EA Vucic, KL Thu, K Robison, LA Rybaczyk, R Chari, CE Alvarez, WL Lam Genome research 22 (2), 188-195, 2012 | 148 | 2012 |
| Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma WW Lockwood, R Chari, BP Coe, KL Thu, C Garnis, CA Malloff, ... PLoS medicine 7 (7), e1000315, 2010 | 135 | 2010 |
| CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non–small-cell lung cancer KW Tam, W Zhang, J Soh, V Stastny, M Chen, H Sun, K Thu, JJ Rios, ... Journal of thoracic oncology 8 (11), 1378-1388, 2013 | 114 | 2013 |
| AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer SP Kubli, C Bassi, C Roux, A Wakeham, C Göbl, W Zhou, SM Jafari, ... Proceedings of the National Academy of Sciences 116 (9), 3604-3613, 2019 | 112 | 2019 |
| Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer BP Coe, KL Thu, S Aviel-Ronen, EA Vucic, AF Gazdar, S Lam, MS Tsao, ... PloS one 8 (8), e71670, 2013 | 103 | 2013 |
| Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer SD Bailey, K Desai, KJ Kron, P Mazrooei, NA Sinnott-Armstrong, ... Nature genetics 48 (10), 1260-1266, 2016 | 102 | 2016 |
| EZH2 promotes E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation R Hubaux, KL Thu, BP Coe, C MacAulay, S Lam, WL Lam Journal of Thoracic Oncology 8 (8), 1102-1106, 2013 | 100 | 2013 |
| Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role PL Clermont, L Sun, F Crea, KL Thu, A Zhang, A Parolia, WL Lam, ... British journal of cancer 111 (8), 1663-1672, 2014 | 98 | 2014 |
| Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer PL Clermont, F Crea, YT Chiang, D Lin, A Zhang, JZL Wang, A Parolia, ... Clinical epigenetics 8, 1-14, 2016 | 90 | 2016 |
| Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers M Kawakami, LM Mustachio, L Zheng, Y Chen, J Rodriguez-Canales, ... Proceedings of the National Academy of Sciences 115 (8), 1913-1918, 2018 | 86 | 2018 |
| Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability KL Thu, EA Vucic, R Chari, W Zhang, WW Lockwood, JC English, R Fu, ... PloS one 7 (3), e33003, 2012 | 85 | 2012 |
Wan L. LamBC Cancer Research Centre; University of British ColumbiaVerified email at bccrc.ca