Estrogens and androgens in skeletal physiology and pathophysiology M Almeida, MR Laurent, V Dubois, F Claessens, CA O'Brien, R Bouillon, ... Physiological reviews 97 (1), 135-187, 2017 | 829 | 2017 |
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids M Almeida, LI Han, M Martin-Millan, LI Plotkin, SA Stewart, PK Roberson, ... Journal of Biological Chemistry 282 (37), 27285-27297, 2007 | 780 | 2007 |
The role of estrogen and androgen receptors in bone health and disease SC Manolagas, CA O'brien, M Almeida Nature Reviews Endocrinology 9 (12), 699, 2013 | 678 | 2013 |
Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor-to forkhead box O-mediated transcription M Almeida, L Han, M Martin-Millan, CA O'Brien, SC Manolagas Journal of Biological Chemistry 282 (37), 27298-27305, 2007 | 617 | 2007 |
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling cascades involving Src … M Almeida, L Han, T Bellido, SC Manolagas, S Kousteni Journal of Biological Chemistry 280 (50), 41342-41351, 2005 | 521 | 2005 |
Gone with the Wnts: β-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism SC Manolagas, M Almeida Molecular Endocrinology 21 (11), 2605-2614, 2007 | 413 | 2007 |
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids S Kousteni, L Han, JR Chen, M Almeida, LI Plotkin, T Bellido, ... The Journal of clinical investigation 111 (11), 1651-1664, 2003 | 361 | 2003 |
The estrogen receptor-α in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone M Martin-Millan, M Almeida, E Ambrogini, L Han, H Zhao, RS Weinstein, ... Molecular endocrinology 24 (2), 323-334, 2010 | 354 | 2010 |
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice E Ambrogini, M Almeida, M Martin-Millan, JH Paik, RA DePinho, L Han, ... Cell metabolism 11 (2), 136-146, 2010 | 320 | 2010 |
Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-γ expression, and diminished pro-osteogenic Wnt signaling in the skeleton M Almeida, E Ambrogini, L Han, SC Manolagas, RL Jilka Journal of Biological Chemistry 284 (40), 27438-27448, 2009 | 320 | 2009 |
Glucocorticoids and tumor necrosis factor α increase oxidative stress and suppress Wnt protein signaling in osteoblasts M Almeida, L Han, E Ambrogini, RS Weinstein, SC Manolagas Journal of Biological Chemistry 286 (52), 44326-44335, 2011 | 307 | 2011 |
Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice RS Weinstein, C Wan, Q Liu, Y Wang, M Almeida, CA O’Brien, ... Aging cell 9 (2), 147-161, 2010 | 306 | 2010 |
Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual M Almeida, S Iyer, M Martin-Millan, SM Bartell, L Han, E Ambrogini, ... The Journal of clinical investigation 123 (1), 2012 | 302 | 2012 |
Stimulation of Piezo1 by mechanical signals promotes bone anabolism X Li, L Han, I Nookaew, E Mannen, MJ Silva, M Almeida, J Xiong elife 8, e49631, 2019 | 289 | 2019 |
SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass EM Mercken, SJ Mitchell, A Martin‐Montalvo, RK Minor, M Almeida, ... Aging cell 13 (5), 787-796, 2014 | 262 | 2014 |
Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss M Onal, J Xiong, X Chen, JD Thostenson, M Almeida, SC Manolagas, ... Journal of Biological Chemistry 287 (35), 29851-29860, 2012 | 261 | 2012 |
FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation SM Bartell, HN Kim, E Ambrogini, L Han, S Iyer, S Serra Ucer, ... Nature communications 5 (1), 3773, 2014 | 257 | 2014 |
Basic biology of skeletal aging: role of stress response pathways M Almeida, CA O’Brien Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences …, 2013 | 255 | 2013 |
FOXOs attenuate bone formation by suppressing Wnt signaling S Iyer, E Ambrogini, SM Bartell, L Han, PK Roberson, R de Cabo, RL Jilka, ... The Journal of clinical investigation 123 (8), 3409-3419, 2013 | 244 | 2013 |
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity Y He, X Zhang, J Chang, HN Kim, P Zhang, Y Wang, S Khan, X Liu, ... Nature communications 11 (1), 1996, 2020 | 225 | 2020 |