| Small-molecule inhibitors of protein–protein interactions: progressing towards the dream MR Arkin, JA Wells Nature reviews Drug discovery 3 (4), 301-317, 2004 | 2112 | 2004 |
| Long-range photoinduced electron transfer through a DNA helix CJ Murphy, MR Arkin, Y Jenkins, ND Ghatlia, SH Bossmann, NJ Turro, ... Science 262 (5136), 1025-1029, 1993 | 1391 | 1993 |
| Small-molecule inhibitors of protein-protein interactions: progressing toward the reality MR Arkin, Y Tang, JA Wells Chemistry & biology 21 (9), 1102-1114, 2014 | 1198 | 2014 |
| Pharmacological brake-release of mRNA translation enhances cognitive memory C Sidrauski, D Acosta-Alvear, A Khoutorsky, P Vedantham, BR Hearn, ... elife 2, e00498, 2013 | 696 | 2013 |
| Rates of DNA-mediated electron transfer between metallointercalators MR Arkin, EDA Stemp, RE Holmlin, JK Barton, A Hörmann, EJC Olson, ... Science 273 (5274), 475-480, 1996 | 566 | 1996 |
| Binding of small molecules to an adaptive protein–protein interface MR Arkin, M Randal, WL DeLano, J Hyde, TN Luong, JD Oslob, ... Proceedings of the National Academy of Sciences 100 (4), 1603-1608, 2003 | 489 | 2003 |
| First observation of the key intermediate in the “light-switch” mechanism of [Ru (phen) 2dppz] 2+ EJC Olson, D Hu, A Hörmann, AM Jonkman, MR Arkin, EDA Stemp, ... Journal of the American Chemical Society 119 (47), 11458-11467, 1997 | 454 | 1997 |
| 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition S Banerjee, A Bartesaghi, A Merk, P Rao, SL Bulfer, Y Yan, N Green, ... Science 351 (6275), 871-875, 2016 | 390 | 2016 |
| A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target A Debnath, D Parsonage, RM Andrade, C He, ER Cobo, K Hirata, S Chen, ... Nature medicine 18 (6), 956-960, 2012 | 352 | 2012 |
| USP7 small-molecule inhibitors interfere with ubiquitin binding L Kategaya, P Di Lello, L Rougé, R Pastor, KR Clark, J Drummond, ... Nature 550 (7677), 534-538, 2017 | 315 | 2017 |
| Oxidation of guanine in DNA by Ru (phen) 2 (dppz) 3+ using the flash-quench technique EDA Stemp, MR Arkin, JK Barton Journal of the American Chemical Society 119 (12), 2921-2925, 1997 | 313 | 1997 |
| Discovery of a potent small molecule IL-2 inhibitor through fragment assembly AC Braisted, JD Oslob, WL Delano, J Hyde, RS McDowell, N Waal, C Yu, ... Journal of the American Chemical Society 125 (13), 3714-3715, 2003 | 309 | 2003 |
| High-throughput screening: today’s biochemical and cell-based approaches V Blay, B Tolani, SP Ho, MR Arkin Drug Discovery Today 25 (10), 1807-1821, 2020 | 264 | 2020 |
| Fast photoinduced electron transfer through DNA intercalation. CJ Murphy, MR Arkin, ND Ghatlia, S Bossmann, NJ Turro, JK Barton Proceedings of the National Academy of Sciences 91 (12), 5315-5319, 1994 | 260 | 1994 |
| Long-range oxidation of guanine by Ru (III) in duplex DNA MR Arkin, EDA Stemp, SC Pulver, JK Barton Chemistry & Biology 4 (5), 389-400, 1997 | 257 | 1997 |
| A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit G De Muylder, KKH Ang, S Chen, MR Arkin, JC Engel, JH McKerrow PLoS neglected tropical diseases 5 (7), e1253, 2011 | 239 | 2011 |
| Protein–protein interactions and cancer: small molecules going in for the kill M Arkin Current opinion in chemical biology 9 (3), 317-324, 2005 | 239 | 2005 |
| Assay guidance manual GS Sittampalam, NP Coussens, H Nelson, M Arkin, D Auld, C Austin, ... Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004 | 239 | 2004 |
| Screening for noise in gene expression identifies drug synergies RD Dar, NN Hosmane, MR Arkin, RF Siliciano, LS Weinberger Science 344 (6190), 1392-1396, 2014 | 229 | 2014 |
| Two approaches to discovering and developing new drugs for Chagas disease JH McKerrow, PS Doyle, JC Engel, LM Podust, SA Robertson, R Ferreira, ... Memórias do Instituto Oswaldo Cruz 104, 263-269, 2009 | 228 | 2009 |
Adam R. RensloProfessor, UCSFVerified email at ucsf.edu