| CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy W Wang, M Green, JE Choi, M Gijón, PD Kennedy, JK Johnson, P Liao, ... Nature 569 (7755), 270-274, 2019 | 2167 | 2019 |
| Cysteine depletion induces pancreatic tumor ferroptosis in mice MA Badgley, DM Kremer, HC Maurer, KE DelGiorno, HJ Lee, V Purohit, ... Science 368 (6486), 85-89, 2020 | 1003 | 2020 |
| Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11 X Lang, MD Green, W Wang, J Yu, JE Choi, L Jiang, P Liao, J Zhou, ... Cancer discovery 9 (12), 1673-1685, 2019 | 800 | 2019 |
| Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth SL Cramer, A Saha, J Liu, S Tadi, S Tiziani, W Yan, K Triplett, C Lamb, ... Nature medicine 23 (1), 120-127, 2017 | 518 | 2017 |
| Reversal of indoleamine 2, 3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme TA Triplett, KC Garrison, N Marshall, M Donkor, J Blazeck, C Lamb, ... Nature biotechnology 36 (8), 758-764, 2018 | 279 | 2018 |
| Non-canonical glutamate-cysteine ligase activity protects against ferroptosis YP Kang, A Mockabee-Macias, C Jiang, A Falzone, N Prieto-Farigua, ... Cell metabolism 33 (1), 174-189. e7, 2021 | 261 | 2021 |
| Oncogene-selective sensitivity to synchronous cell death following modulation of the amino acid nutrient cystine I Poursaitidis, X Wang, T Crighton, C Labuschagne, D Mason, SL Cramer, ... Cell reports 18 (11), 2547-2556, 2017 | 236 | 2017 |
| A genome-wide haploid genetic screen identifies regulators of glutathione abundance and ferroptosis sensitivity JY Cao, A Poddar, L Magtanong, JH Lumb, TR Mileur, MA Reid, ... Cell reports 26 (6), 1544-1556. e8, 2019 | 193 | 2019 |
| The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein PW Thomas, EM Stone, AL Costello, DL Tierney, W Fast Biochemistry 44 (20), 7559-7569, 2005 | 174 | 2005 |
| Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis D Liu, BW Lepore, GA Petsko, PW Thomas, EM Stone, W Fast, D Ringe Proceedings of the National Academy of Sciences 102 (33), 11882-11887, 2005 | 149 | 2005 |
| Replacing Mn2+ with Co2+ in Human Arginase I Enhances Cytotoxicity toward l-Arginine Auxotrophic Cancer Cell Lines EM Stone, ES Glazer, L Chantranupong, P Cherukuri, RM Breece, ... ACS chemical biology 5 (3), 333-342, 2010 | 146 | 2010 |
| Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase EM Stone, TH Schaller, H Bianchi, MD Person, W Fast Biochemistry 44 (42), 13744-13752, 2005 | 107 | 2005 |
| Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11. Cancer Discov., 2019, 9 (12), 1673-1685. doi: 10.1158/2159 … X Lang, MD Green, W Wang, J Yu, JE Choi, L Jiang, P Liao, J Zhou, ... CD-19-0338 PMID: 31554642, 1997 | 107 | 1997 |
| Tryptophan depletion results in tryptophan-to-phenylalanine substitutants A Pataskar, J Champagne, R Nagel, J Kenski, M Laos, J Michaux, HS Pak, ... Nature 603 (7902), 721-727, 2022 | 103 | 2022 |
| The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with β-aspartyl peptidase activity JR Cantor, EM Stone, L Chantranupong, G Georgiou Biochemistry 48 (46), 11026-11031, 2009 | 98 | 2009 |
| Bioengineered human arginase I with enhanced activity and stability controls hepatocellular and pancreatic carcinoma xenografts ES Glazer, EM Stone, C Zhu, KL Massey, AN Hamir, SA Curley Translational oncology 4 (3), 138-146, 2011 | 96 | 2011 |
| Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells O Khoury, N Ghazale, E Stone, M El-Sibai, AE Frankel, RJ Abi-Habib Journal of neuro-oncology 122, 75-85, 2015 | 79 | 2015 |
| Engineering reduced-immunogenicity enzymes for amino acid depletion therapy in cancer JR Cantor, V Panayiotou, G Agnello, G Georgiou, EM Stone Methods in enzymology 502, 291-319, 2012 | 72 | 2012 |
| SCHEMA-designed variants of human arginase I and II reveal sequence elements important to stability and catalysis PA Romero, E Stone, C Lamb, L Chantranupong, A Krause, AE Miklos, ... ACS synthetic biology 1 (6), 221-228, 2012 | 66 | 2012 |
| Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells R Tanios, A Bekdash, E Kassab, E Stone, G Georgiou, AE Frankel, ... Leukemia Research 37 (11), 1565-1571, 2013 | 63 | 2013 |
George GeorgiouUniversity of Texas at AustinVerified email at che.utexas.edu