| Thrombin promotes diet-induced obesity through fibrin-driven inflammation AK Kopec, SR Abrahams, S Thornton, JS Palumbo, ES Mullins, ... The Journal of clinical investigation 127 (8), 3152-3166, 2017 | 130 | 2017 |
| Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium CM Thompson, DM Proctor, LC Haws, CD Hébert, SD Grimes, ... Toxicological Sciences 123 (1), 58-70, 2011 | 96 | 2011 |
| Role of the blood coagulation cascade in hepatic fibrosis A Pant, AK Kopec, JP Luyendyk American Journal of Physiology-Gastrointestinal and Liver Physiology 315 (2 …, 2018 | 82 | 2018 |
| Hepatocyte tissue factor activates the coagulation cascade in mice BP Sullivan, AK Kopec, N Joshi, H Cline, JA Brown, SC Bishop, ... Blood, The Journal of the American Society of Hematology 121 (10), 1868-1874, 2013 | 79 | 2013 |
| Fibrin (ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12 AK Kopec, N Joshi, H Cline-Fedewa, AV Wojcicki, JL Ray, BP Sullivan, ... Journal of hepatology 66 (4), 787-797, 2017 | 76 | 2017 |
| Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice AK Kopec, LD Burgoon, D Ibrahim-Aibo, AR Burg, AW Lee, C Tashiro, ... Toxicological Sciences 118 (1), 286-297, 2010 | 73 | 2010 |
| Thrombin Inhibition with Dabigatran Protects against High-Fat Diet-Induced Fatty Liver Disease in Mice AK Kopec, N Joshi, KM Kassel, BP Sullivan, MJ Flick, JP Luyendyk J Pharmacol Exp Ther. 351 (2), 288-97, 2014 | 71 | 2014 |
| PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands AK Kopec, LD Burgoon, D Ibrahim-Aibo, BD Mets, C Tashiro, D Potter, ... Toxicology and applied pharmacology 243 (3), 359-371, 2010 | 63 | 2010 |
| Intrahepatic fibrin (ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans D Groeneveld, D Pereyra, Z Veldhuis, J Adelmeijer, P Ottens, AK Kopec, ... Blood, The Journal of the American Society of Hematology 133 (11), 1245-1256, 2019 | 62 | 2019 |
| Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water AK Kopec, S Kim, AL Forgacs, TR Zacharewski, DM Proctor, MA Harris, ... Toxicology and applied pharmacology 259 (1), 13-26, 2012 | 60 | 2012 |
| Role of hemostatic factors in hepatic injury and disease: animal models de‐liver AK Kopec, N Joshi, JP Luyendyk Journal of Thrombosis and Haemostasis 14 (7), 1337-1349, 2016 | 58 | 2016 |
| Coagulation in liver toxicity and disease: role of hepatocyte tissue factor AK Kopec, JP Luyendyk Thrombosis research 133, S57-S59, 2014 | 57 | 2014 |
| Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate) SW Baran, PC Brown, AR Baudy, SC Fitzpatrick, C Frantz, A Fullerton, ... ALTEX-Alternatives to animal experimentation 39 (2), 297-314, 2022 | 56 | 2022 |
| Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury PE Rautou, K Tatsumi, S Antoniak, AP Owens III, E Sparkenbaugh, ... Journal of hepatology 64 (1), 53-59, 2016 | 53 | 2016 |
| Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice. N Joshi, AK Kopec, KM O'Brien, KL Towery, H Cline-Fedewa, KJ Williams, ... J Thromb Haemost, 2014 | 53 | 2014 |
| Dietary docosahexaenoic acid prevents silica-induced development of pulmonary ectopic germinal centers and glomerulonephritis in the lupus-prone NZBWF1 mouse MA Bates, P Akbari, KN Gilley, JG Wagner, N Li, AK Kopec, KA Wierenga, ... Frontiers in immunology 9, 2002, 2018 | 50 | 2018 |
| A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice A Miszta, AK Kopec, A Pant, LA Holle, JR Byrnes, DA Lawrence, ... Blood, The Journal of the American Society of Hematology 135 (19), 1704-1717, 2020 | 48 | 2020 |
| Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice AK Kopec, DR Boverhof, LD Burgoon, D Ibrahim-Aibo, JR Harkema, ... Toxicological sciences 102 (1), 61-75, 2008 | 45 | 2008 |
| Towards in vitro models for reducing or replacing the use of animals in drug testing DM Stresser, AK Kopec, P Hewitt, RN Hardwick, TR Van Vleet, ... Nature Biomedical Engineering 8 (8), 930-935, 2024 | 44 | 2024 |
| From the cover: coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis R Nault, KA Fader, AK Kopec, JR Harkema, TR Zacharewski, ... Toxicological Sciences 154 (2), 381-391, 2016 | 40 | 2016 |
Nikita JoshiMichigan State University, Northwestern UniversityVerified email at msu.edu