| Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies Y Yamazaki, N Zhao, TR Caulfield, CC Liu, G Bu Nature Reviews Neurology 15 (9), 501-518, 2019 | 1157 | 2019 |
| Blood-brain barrier dysfunction and the pathogenesis of Alzheimer’s disease Y Yamazaki, T Kanekiyo International journal of molecular sciences 18 (9), 1965, 2017 | 404 | 2017 |
| APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 273 | 2020 |
| Vascular cell senescence contributes to blood–brain barrier breakdown Y Yamazaki, DJ Baker, M Tachibana, CC Liu, JM van Deursen, TG Brott, ... Stroke, STROKEAHA. 115.010835, 2016 | 237 | 2016 |
| Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 207 | 2020 |
| Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression Y Yamazaki, M Shinohara, M Shinohara, A Yamazaki, ME Murray, ... Brain 142 (4), 1077-1092, 2019 | 178 | 2019 |
| ABCA7 deficiency accelerates amyloid-β generation and Alzheimer's neuronal pathology N Sakae, CC Liu, M Shinohara, J Frisch-Daiello, L Ma, Y Yamazaki, ... Journal of Neuroscience 36 (13), 3848-3859, 2016 | 173 | 2016 |
| APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1 M Tachibana, ML Holm, CC Liu, M Shinohara, T Aikawa, H Oue, ... The Journal of clinical investigation 129 (3), 1272-1277, 2019 | 151 | 2019 |
| Apolipoprotein E as a therapeutic target in Alzheimer’s disease: a review of basic research and clinical evidence Y Yamazaki, MM Painter, G Bu, T Kanekiyo CNS drugs 30 (9), 773-789, 2016 | 149 | 2016 |
| Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease M Shinohara, ME Murray, RD Frank, M Shinohara, M DeTure, Y Yamazaki, ... Acta neuropathologica 132, 225-234, 2016 | 114 | 2016 |
| Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, ... Nature neuroscience 25 (8), 1020-1033, 2022 | 109 | 2022 |
| Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease L Zhang, S Zhang, I Maezawa, S Trushin, P Minhas, M Pinto, LW Jin, ... EBioMedicine 2 (4), 294-305, 2015 | 104 | 2015 |
| ApoE (Apolipoprotein E) in brain pericytes regulates endothelial function in an isoform-dependent manner by modulating basement membrane components Y Yamazaki, M Shinohara, A Yamazaki, Y Ren, YW Asmann, T Kanekiyo, ... Arteriosclerosis, thrombosis, and vascular biology 40 (1), 128-144, 2020 | 74 | 2020 |
| Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice M Tachibana, Y Yamazaki, CC Liu, G Bu, T Kanekiyo Experimental neurology 300, 13-21, 2018 | 73 | 2018 |
| Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway CS Casey, Y Atagi, Y Yamazaki, M Shinohara, M Tachibana, Y Fu, G Bu, ... Journal of Biological Chemistry 290 (22), 14208-14217, 2015 | 71 | 2015 |
| ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain T Aikawa, Y Ren, Y Yamazaki, M Tachibana, MR Johnson, CT Anderson, ... Proceedings of the National Academy of Sciences 116 (47), 23790-23796, 2019 | 69 | 2019 |
| Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus Y Yamazaki, T Takahashi, M Hiji, T Kurashige, Y Izumi, T Yamawaki, ... Neuroscience letters 477 (2), 86-90, 2010 | 67 | 2010 |
| Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1 M Tachibana, M Shinohara, Y Yamazaki, CC Liu, J Rogers, G Bu, ... Experimental neurology 277, 1-9, 2016 | 64 | 2016 |
| Vascular ApoE4 impairs behavior by modulating gliovascular function Y Yamazaki, CC Liu, A Yamazaki, F Shue, YA Martens, Y Chen, W Qiao, ... Neuron 109 (3), 438-447. e6, 2021 | 53 | 2021 |
| Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice A Stojakovic, S Trushin, A Sheu, L Khalili, SY Chang, X Li, T Christensen, ... Communications biology 4 (1), 61, 2021 | 51 | 2021 |
Takahisa Kanekiyo, MD, PhDDepartment of Neuroscience, Mayo Clinic JacksonvilleVerified email at mayo.edu
