| Genetic lineage tracing defines myofibroblast origin and function in the injured heart O Kanisicak, H Khalil, MJ Ivey, J Karch, BD Maliken, RN Correll, MJ Brody, ... Nature communications 7, 12260, 2016 | 846 | 2016 |
| Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis H Khalil, O Kanisicak, V Prasad, RN Correll, X Fu, T Schips, RJ Vagnozzi, ... The Journal of clinical investigation 127 (10), 3770-3783, 2017 | 837 | 2017 |
| c-kit+ cells minimally contribute cardiomyocytes to the heart JH Van Berlo, O Kanisicak, M Maillet, RJ Vagnozzi, J Karch, SCJ Lin, ... Nature 509 (7500), 337-341, 2014 | 639 | 2014 |
| Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice JW Elrod, R Wong, S Mishra, RJ Vagnozzi, B Sakthievel, ... The Journal of clinical investigation 120 (10), 3680-3687, 2010 | 445 | 2010 |
| Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice J Karch, JQ Kwong, AR Burr, MA Sargent, JW Elrod, PM Peixoto, ... elife 2, e00772, 2013 | 332 | 2013 |
| Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD J Karch, MJ Bround, H Khalil, MA Sargent, N Latchman, N Terada, ... Science advances 5 (8), eaaw4597, 2019 | 220 | 2019 |
| Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy JQ Kwong, J Davis, CP Baines, MA Sargent, J Karch, X Wang, T Huang, ... Cell Death & Differentiation 21 (8), 1209-1217, 2014 | 191 | 2014 |
| Regulated necrotic cell death: the passive aggressive side of Bax and Bak J Karch, JD Molkentin Circulation research 116 (11), 1800-1809, 2015 | 185 | 2015 |
| Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions P Bernardi, C Gerle, AP Halestrap, EA Jonas, J Karch, N Mnatsakanyan, ... Cell Death & Differentiation 30 (8), 1869-1885, 2023 | 144 | 2023 |
| Identifying the components of the elusive mitochondrial permeability transition pore J Karch, JD Molkentin Proceedings of the National Academy of Sciences 111 (29), 10396-10397, 2014 | 141 | 2014 |
| Necroptosis interfaces with MOMP and the MPTP in mediating cell death J Karch, O Kanisicak, MJ Brody, MA Sargent, DM Michael, JD Molkentin PloS one 10 (6), e0130520, 2015 | 119 | 2015 |
| Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer CES Comstock, MA Augello, RP Benito, J Karch, TH Tran, FE Utama, ... Clinical Cancer Research 15 (17), 5338-5349, 2009 | 110 | 2009 |
| Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak J Karch, TG Schips, BD Maliken, MJ Brody, MA Sargent, O Kanisicak, ... Elife 6, e30543, 2017 | 91 | 2017 |
| Mitochondrial permeability transition pore-dependent necrosis DJ Robichaux, M Harata, E Murphy, J Karch Journal of molecular and cellular cardiology 174, 47-55, 2023 | 81 | 2023 |
| P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism ER Wissing, JG Boyer, JQ Kwong, MA Sargent, J Karch, EM McNally, ... Human molecular genetics 23 (20), 5452-5463, 2014 | 66 | 2014 |
| Regulation of cell death in the cardiovascular system P Patel, J Karch International review of cell and molecular biology 353, 153-209, 2020 | 53 | 2020 |
| Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function CES Comstock, MA Augello, MJ Schiewer, J Karch, CJ Burd, A Ertel, ... Journal of Biological Chemistry 286 (10), 8117-8127, 2011 | 51 | 2011 |
| Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability TG Schips, D Vanhoutte, A Vo, RN Correll, MJ Brody, H Khalil, J Karch, ... Nature communications 10 (1), 76, 2019 | 50 | 2019 |
| Gata4-Dependent Differentiation of c-Kit+–Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart BD Maliken, O Kanisicak, J Karch, H Khalil, X Fu, JG Boyer, V Prasad, ... Circulation 138 (10), 1012-1024, 2018 | 45 | 2018 |
| Is p53 the Long-Sought Molecular Trigger for Cyclophilin D–Regulated Mitochondrial Permeability Transition Pore Formation and Necrosis? J Karch, JD Molkentin Circulation research 111 (10), 1258-1260, 2012 | 38 | 2012 |
Jeffery D MolkentinCincinnati Children's Hospital, USAVerified email at cchmc.org