| Machine learning-aided engineering of hydrolases for PET depolymerization H Lu, DJ Diaz, NJ Czarnecki, C Zhu, W Kim, R Shroff, DJ Acosta, ... Nature 604 (7907), 662-667, 2022 | 796 | 2022 |
| Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals EJ Olson, LA Hartsough, BP Landry, R Shroff, JJ Tabor Nature methods 11 (4), 449-455, 2014 | 232 | 2014 |
| Synthetic evolutionary origin of a proofreading reverse transcriptase JW Ellefson, J Gollihar, R Shroff, H Shivram, VR Iyer, AD Ellington Science 352 (6293), 1590-1593, 2016 | 147 | 2016 |
| Fragile X AGG analysis provides new risk predictions for 45–69 repeat alleles SL Nolin, S Sah, A Glicksman, SL Sherman, E Allen, E Berry‐Kravis, ... American Journal of Medical Genetics Part A 161 (4), 771-778, 2013 | 143 | 2013 |
| Discovery of novel gain-of-function mutations guided by structure-based deep learning R Shroff, AW Cole, DJ Diaz, BR Morrow, I Donnell, A Annapareddy, ... ACS synthetic biology 9 (11), 2927-2935, 2020 | 131 | 2020 |
| Microbiota and metatranscriptome changes accompanying the onset of gingivitis EM Nowicki, R Shroff, JA Singleton, DE Renaud, D Wallace, J Drury, ... MBio 9 (2), 10.1128/mbio. 00575-18, 2018 | 108 | 2018 |
| Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains R Thyer, R Shroff, DR Klein, S d'Oelsnitz, VC Cotham, M Byrom, ... Nature biotechnology 36 (7), 624-631, 2018 | 50 | 2018 |
| Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach I Paik, PHT Ngo, R Shroff, DJ Diaz, AC Maranhao, DJF Walker, S Bhadra, ... Biochemistry 62 (2), 410-418, 2021 | 49 | 2021 |
| Evolution of a thermophilic strand-displacing polymerase using high-temperature isothermal compartmentalized self-replication JN Milligan, R Shroff, DJ Garry, AD Ellington Biochemistry 57 (31), 4607-4619, 2018 | 49 | 2018 |
| DLPacker: Deep learning for prediction of amino acid side chain conformations in proteins M Misiura, R Shroff, R Thyer, AB Kolomeisky Proteins: Structure, Function, and Bioinformatics 90 (6), 1278-1290, 2022 | 42 | 2022 |
| Cellular reagents for diagnostics and synthetic biology S Bhadra, A Pothukuchy, R Shroff, AW Cole, M Byrom, JW Ellefson, ... PLoS One 13 (8), e0201681, 2018 | 31 | 2018 |
| A structure-based deep learning framework for protein engineering R Shroff, AW Cole, BR Morrow, DJ Diaz, I Donnell, J Gollihar, ... BioRxiv, 833905, 2019 | 14 | 2019 |
| Evolving bacterial fitness with an expanded genetic code DS Tack, AC Cole, R Shroff, BR Morrow, AD Ellington Scientific Reports 8 (1), 3288, 2018 | 14 | 2018 |
| Deep learning redesign of PETase for practical PET degrading applications H Lu, DJ Diaz, NJ Czarnecki, C Zhu, W Kim, R Shroff, DJ Acosta, ... Biorxiv, 2021.10. 10.463845, 2021 | 9 | 2021 |
| Recovery of Information Stored in Modified DNA with an Evolved Polymerase R Shroff, JW Ellefson, SS Wang, AA Boulgakov, RA Hughes, AD Ellington ACS Synthetic Biology 11 (2), 554-561, 2022 | 8 | 2022 |
| SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode J Goike, CL Hsieh, AP Horton, EC Gardner, L Zhou, F Bartzoka, N Wang, ... Communications Biology 6 (1), 1250, 2023 | 6 | 2023 |
| Multi-modal engineering of Bst DNA polymerase for thermostability in ultra-fast LAMP reactions I Paik, PHT Ngo, R Shroff, AC Maranhao, DJF Walker, S Bhadra, ... bioRxiv, 2021.04. 15.439918, 2021 | 6 | 2021 |
| Methods for nucleic acid size detection of repeat sequences E Bram, R Shroff, A Hadd, B Printy US Patent App. 15/343,057, 2017 | 3 | 2017 |
| Methods and kits for using recombinant microorganisms as direct reagents in biological applications A Ellington, S Bhadra, J Ellefson, J Gollihar, A Pothukuchy, M Byrom, ... US Patent 11,807,901, 2023 | 1 | 2023 |
| System and method for increasing synthesized protein stability A Ellington, A Cole, R Shroff, R Thyer US Patent 11,551,786, 2023 | 1 | 2023 |
