Articles with public access mandates - John CirritoLearn more
Not available anywhere: 4
Opportunities for drug repurposing of serotonin reuptake inhibitors: potential uses in inflammation, infection, cancer, neuroprotection, and Alzheimer’s disease prevention
MJ Nykamp, CF Zorumski, AM Reiersen, GE Nicol, J Cirrito, EJ Lenze
Pharmacopsychiatry 55 (01), 24-29, 2022
Mandates: US National Institutes of Health, Patient-Centered Outcomes Research Institute
S4‐04‐06: Dimebon®: A Clinically Promising Drug for Alzheimer's Disease, Regulates Amyloid‐Beta Metabolism in Cultured Cells, In Isolated Nerve Terminals, and In the …
S Gandy, J Cirrito, J Steele, SH Kim, G Thinakaran, D Westaway, P Fraser, ...
Alzheimer's & Dementia 5 (4S_Part_5), e5-e5, 2009
Mandates: US National Institutes of Health
γ-Secretase Modulation inhibits Amyloid Plaque Formation and Growth and stimulates Plaque Regression in APP/PS1 Mice
G Nordvall, P Yan, L Agholme, J Lundkvist, J Sandin, H Biverstål, ...
The Journal of Pharmacology and Experimental Therapeutics, 103400, 2025
Mandates: UK Medical Research Council, European Commission, Vinnova, Sweden
P4‐268: APP endocytosis is required for synaptic‐dependent release of amyloid‐beta in vivo
JR Cirrito, FR Stewart, S Mennerick, DM Holtzman
Alzheimer's & Dementia 4, T750-T750, 2008
Mandates: US National Institutes of Health
Available somewhere: 69
Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle
JE Kang, MM Lim, RJ Bateman, JJ Lee, LP Smyth, JR Cirrito, N Fujiki, ...
Science 326 (5955), 1005-1007, 2009
Mandates: US National Institutes of Health
TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model
Y Wang, M Cella, K Mallinson, JD Ulrich, KL Young, ML Robinette, ...
Cell 160 (6), 1061-1071, 2015
Mandates: US National Institutes of Health
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
PE Cramer, JR Cirrito, DW Wesson, CYD Lee, JC Karlo, AE Zinn, ...
science 335 (6075), 1503-1506, 2012
Mandates: US National Institutes of Health
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
AW Bero, P Yan, JH Roh, JR Cirrito, FR Stewart, ME Raichle, JM Lee, ...
Nature neuroscience 14 (6), 750-756, 2011
Mandates: US National Institutes of Health
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Y Wang, TK Ulland, JD Ulrich, W Song, JA Tzaferis, JT Hole, P Yuan, ...
Journal of Experimental Medicine 213 (5), 667-675, 2016
Mandates: US National Institutes of Health
Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo
JR Cirrito, JE Kang, J Lee, FR Stewart, DK Verges, LM Silverio, G Bu, ...
Neuron 58 (1), 42-51, 2008
Mandates: US National Institutes of Health
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
JK Holth, SK Fritschi, C Wang, NP Pedersen, JR Cirrito, TE Mahan, ...
Science 363 (6429), 880-884, 2019
Mandates: US National Institutes of Health, German Research Foundation
Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model
PE Sanchez, L Zhu, L Verret, KA Vossel, AG Orr, JR Cirrito, N Devidze, ...
Proceedings of the National Academy of Sciences 109 (42), E2895-E2903, 2012
Mandates: US National Institutes of Health
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
K Yamada, JR Cirrito, FR Stewart, H Jiang, MB Finn, BB Holmes, ...
Journal of Neuroscience 31 (37), 13110-13117, 2011
Mandates: US National Institutes of Health
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans
JR Cirrito, BM Disabato, JL Restivo, DK Verges, WD Goebel, A Sathyan, ...
Proceedings of the National Academy of Sciences 108 (36), 14968-14973, 2011
Mandates: US National Institutes of Health
Amyloid‐beta oligomerization in Alzheimer dementia versus high‐pathology controls
TJ Esparza, H Zhao, JR Cirrito, NJ Cairns, RJ Bateman, DM Holtzman, ...
Annals of neurology 73 (1), 104-119, 2013
Mandates: US National Institutes of Health
Antisense reduction of tau in adult mice protects against seizures
SL DeVos, DK Goncharoff, G Chen, CS Kebodeaux, K Yamada, ...
Journal of Neuroscience 33 (31), 12887-12897, 2013
Mandates: US National Institutes of Health
Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice
AW Kraft, X Hu, H Yoon, P Yan, Q Xiao, Y Wang, SC Gil, J Brown, ...
The FASEB Journal 27 (1), 187, 2013
Mandates: US National Institutes of Health, Swedish Research Council
Neuronal clearance of amyloid-β by endocytic receptor LRP1
T Kanekiyo, JR Cirrito, CC Liu, M Shinohara, J Li, DR Schuler, ...
Journal of Neuroscience 33 (49), 19276-19283, 2013
Mandates: US National Institutes of Health
Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice
P Yan, AW Bero, JR Cirrito, Q Xiao, X Hu, Y Wang, E Gonzales, ...
Journal of Neuroscience 29 (34), 10706-10714, 2009
Mandates: US National Institutes of Health
Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis
Q Xiao, P Yan, X Ma, H Liu, R Perez, A Zhu, E Gonzales, JM Burchett, ...
Journal of Neuroscience 34 (29), 9607-9620, 2014
Mandates: US National Institutes of Health
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