| Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans NR Gavva, JJS Treanor, A Garami, L Fang, S Surapaneni, A Akrami, ... PAIN® 136 (1-2), 202-210, 2008 | 580 | 2008 |
| AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2, 3-dihydrobenzo [b][1, 4] dioxin-6-yl) acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties NR Gavva, R Tamir, Y Qu, L Klionsky, TJ Zhang, D Immke, J Wang, D Zhu, ... The journal of pharmacology and experimental therapeutics 313 (1), 474-484, 2005 | 451 | 2005 |
| Molecular determinants of vanilloid sensitivity in TRPV1 NR Gavva, L Klionsky, Y Qu, L Shi, R Tamir, S Edenson, TJ Zhang, ... Journal of biological chemistry 279 (19), 20283-20295, 2004 | 437 | 2004 |
| Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks GY Wong, NR Gavva Brain research reviews 60 (1), 267-277, 2009 | 422 | 2009 |
| The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation NR Gavva, AW Bannon, S Surapaneni, DN Hovland, SG Lehto, A Gore, ... Journal of Neuroscience 27 (13), 3366-3374, 2007 | 387 | 2007 |
| Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors AA Steiner, VF Turek, MC Almeida, JJ Burmeister, DL Oliveira, JL Roberts, ... Journal of Neuroscience 27 (28), 7459-7468, 2007 | 271 | 2007 |
| Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature MC Almeida, T Hew-Butler, RN Soriano, S Rao, W Wang, J Wang, ... Journal of Neuroscience 32 (6), 2086-2099, 2012 | 268 | 2012 |
| The TRPV1 receptor and nociception DC Immke, NR Gavva Seminars in cell & developmental biology 17 (5), 582-591, 2006 | 247 | 2006 |
| The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons A Leffler, MJ Fischer, D Rehner, S Kienel, K Kistner, SK Sauer, NR Gavva, ... The Journal of clinical investigation 118 (2), 763-776, 2008 | 245 | 2008 |
| Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1 NR Gavva Trends in pharmacological sciences 29 (11), 550-557, 2008 | 235 | 2008 |
| Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade NR Gavva, AW Bannon, DN Hovland Jr, SG Lehto, L Klionsky, ... The Journal of pharmacology and experimental therapeutics 323 (1), 128-137, 2007 | 206 | 2007 |
| Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia VL Raghavendra Rao, KK Bowen, VK Dhodda, G Song, JL Franklin, ... Journal of neurochemistry 83 (5), 1072-1086, 2002 | 206 | 2002 |
| Contributions of different modes of TRPV1 activation to TRPV1 antagonist-induced hyperthermia A Garami, YP Shimansky, E Pakai, DL Oliveira, NR Gavva, ... Journal of Neuroscience 30 (4), 1435-1440, 2010 | 198 | 2010 |
| Antihyperalgesic effects of (R, E)-N-(2-hydroxy-2, 3-dihydro-1 H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl) phenyl)-acrylamide (AMG8562), a novel transient receptor … SG Lehto, R Tamir, H Deng, L Klionsky, R Kuang, A Le, D Lee, JC Louis, ... The Journal of pharmacology and experimental therapeutics 326 (1), 218-229, 2008 | 185 | 2008 |
| Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis A Garami, E Pakai, DL Oliveira, AA Steiner, SP Wanner, MC Almeida, ... Journal of Neuroscience 31 (5), 1721-1733, 2011 | 154 | 2011 |
| Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of N-Aryl Cinnamides EM Doherty, C Fotsch, Y Bo, PP Chakrabarti, N Chen, N Gavva, N Han, ... Journal of medicinal chemistry 48 (1), 71-90, 2005 | 143 | 2005 |
| Species-specific pharmacology of Trichloro (sulfanyl) ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists L Klionsky, R Tamir, BX Gao, W Wang, DC Immke, N Nishimura, ... Molecular pain 3, 1744-8069-3-39, 2007 | 137 | 2007 |
| Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1H-benzimidazoles VI Ognyanov, C Balan, AW Bannon, Y Bo, C Dominguez, C Fotsch, ... Journal of medicinal chemistry 49 (12), 3719-3742, 2006 | 114 | 2006 |
| Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation NR Gavva, C Davis, SG Lehto, S Rao, W Wang, DXD Zhu Molecular Pain 8, 1744-8069-8-36, 2012 | 113 | 2012 |
| Novel Vanilloid Receptor-1 Antagonists: 2. Structure− Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate EM Doherty, C Fotsch, AW Bannon, Y Bo, N Chen, C Dominguez, ... Journal of medicinal chemistry 50 (15), 3515-3527, 2007 | 106 | 2007 |