| Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene RS Jackson, JWM Creemers, S Ohagi, ML Raffin-Sanson, L Sanders, ... Nature genetics 16 (3), 303-306, 1997 | 1383 | 1997 |
| Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis D Scheuner, DV Mierde, B Song, D Flamez, JWM Creemers, K Tsukamoto, ... Nature medicine 11 (7), 757-764, 2005 | 473 | 2005 |
| Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency RS Jackson, JWM Creemers, IS Farooqi, ML Raffin-Sanson, A Varro, ... The Journal of clinical investigation 112 (10), 1550-1560, 2003 | 422 | 2003 |
| Common nonsynonymous variants in PCSK1 confer risk of obesity M Benzinou, JWM Creemers, H Choquet, S Lobbens, C Dina, E Durand, ... Nature genetics 40 (8), 943-945, 2008 | 370 | 2008 |
| A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular … BG Challis, LE Pritchard, JWM Creemers, J Delplanque, JM Keogh, ... Human molecular genetics 11 (17), 1997-2004, 2002 | 362 | 2002 |
| Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice K Lemaire, MA Ravier, A Schraenen, JWM Creemers, R Van de Plas, ... Proceedings of the national Academy of Sciences 106 (35), 14872-14877, 2009 | 359 | 2009 |
| Curbing activation: proprotein convertases in homeostasis and pathology NA Taylor, WJM Van De Ven, JWM Creemers The FASEB journal 17 (10), 1215-1227, 2003 | 275 | 2003 |
| Processing of β-secretase by furin and other members of the proprotein convertase family JWM Creemers, DI Dominguez, E Plets, L Serneels, NA Taylor, ... Journal of Biological Chemistry 276 (6), 4211-4217, 2001 | 274 | 2001 |
| Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3 IS Farooqi, K Volders, R Stanhope, R Heuschkel, A White, E Lank, ... The Journal of Clinical Endocrinology & Metabolism 92 (9), 3369-3373, 2007 | 269 | 2007 |
| T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance M Pesu, WT Watford, L Wei, L Xu, I Fuss, W Strober, J Andersson, ... Nature 455 (7210), 246-250, 2008 | 251 | 2008 |
| Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements B De Cat, SY Muyldermans, C Coomans, G Degeest, B Vanderschueren, ... The Journal of cell biology 163 (3), 625-635, 2003 | 226 | 2003 |
| In vivo evidence that furin from hepatocytes inactivates PCSK9 R Essalmani, D Susan-Resiga, A Chamberland, M Abifadel, ... Journal of Biological Chemistry 286 (6), 4257-4263, 2011 | 191 | 2011 |
| Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin … E Lopez‐Perez, Y Zhang, SJ Frank, J Creemers, N Seidah, F Checler Journal of neurochemistry 76 (5), 1532-1539, 2001 | 175 | 2001 |
| Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D S Jansen, C Stefan, JWM Creemers, E Waelkens, A Van Eynde, ... Journal of cell science 118 (14), 3081-3089, 2005 | 173 | 2005 |
| Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, ... Cell metabolism 20 (6), 979-990, 2014 | 172 | 2014 |
| Limited redundancy of the proprotein convertase furin in mouse liver AJM Roebroek, NA Taylor, E Louagie, I Pauli, L Smeijers, A Snellinx, ... Journal of Biological Chemistry 279 (51), 53442-53450, 2004 | 168 | 2004 |
| Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis. JW Creemers, RJ Siezen, AJ Roebroek, TA Ayoubi, D Huylebroeck, ... Journal of Biological Chemistry 268 (29), 21826-21834, 1993 | 168 | 1993 |
| PCSK1 mutations and human endocrinopathies: from obesity to gastrointestinal disorders P Stijnen, B Ramos-Molina, S O'Rahilly, JWM Creemers Endocrine reviews 37 (4), 347-371, 2016 | 164 | 2016 |
| Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP) 83–132: interaction between AGRP83–132 and … JWM Creemers, LE Pritchard, A Gyte, P Le Rouzic, S Meulemans, ... Endocrinology 147 (4), 1621-1631, 2006 | 139 | 2006 |
| Endoproteolytic Cleavage of Its Propeptide Is a Prerequisite for Efficient Transport of Furin Out of the Endoplasmic Reticulum (∗) JWM Creemers, M Vey, W Schäfer, TAY Ayoubi, AJM Roebroek, ... Journal of Biological Chemistry 270 (6), 2695-2702, 1995 | 138 | 1995 |
Frans Schuithoogleraar Metabolisme, Katholieke Universiteit LeuvenVerified email at kuleuven.be