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mike hann
mike hann
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Molecular complexity and its impact on the probability of finding leads for drug discovery
MM Hann, AR Leach, G Harper
Journal of chemical information and computer sciences 41 (3), 856-864, 2001
11942001
Type IIA topoisomerase inhibition by a new class of antibacterial agents
BD Bax, PF Chan, DS Eggleston, A Fosberry, DR Gentry, F Gorrec, ...
Nature 466 (7309), 935-940, 2010
8872010
Recap retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry
XQ Lewell, DB Judd, SP Watson, MM Hann
Journal of chemical information and computer sciences 38 (3), 511-522, 1998
8321998
Pursuing the leadlikeness concept in pharmaceutical research
MM Hann, TI Oprea
Current opinion in chemical biology 8 (3), 255-263, 2004
6852004
Finding the sweet spot: the role of nature and nurture in medicinal chemistry
MM Hann, GM Keserü
Nature reviews Drug discovery 11 (5), 355-365, 2012
4642012
Molecular obesity, potency and other addictions in drug discovery
MM Hann
MedChemComm 2 (5), 349-355, 2011
4342011
Strategic pooling of compounds for high-throughput screening
M Hann, B Hudson, X Lewell, R Lifely, L Miller, N Ramsden
Journal of chemical information and computer sciences 39 (5), 897-902, 1999
2801999
Modulators of 14-3-3 protein–protein interactions
LM Stevers, E Sijbesma, M Botta, C MacKintosh, T Obsil, I Landrieu, ...
Journal of medicinal chemistry 61 (9), 3755-3778, 2017
2732017
Design principles for fragment libraries: maximizing the value of learnings from pharma fragment-based drug discovery (FBDD) programs for use in academia
GM Keserű, DA Erlanson, GG Ferenczy, MM Hann, CW Murray, ...
Journal of medicinal chemistry 59 (18), 8189-8206, 2016
2552016
Molecular complexity and fragment-based drug discovery: ten years on
AR Leach, MM Hann
Current opinion in chemical biology 15 (4), 489-496, 2011
2232011
Fragment screening: an introduction
AR Leach, MM Hann, JN Burrows, EJ Griffen
Molecular BioSystems 2 (9), 429-446, 2006
2212006
On the double bond isostere of the peptide bond: preparation of an enkephalin analogue
MM Hann, PG Sammes, PD Kennewell, JB Taylor
Journal of the Chemical Society, Perkin Transactions 1, 307-314, 1982
1931982
The PROTACtable genome
M Schneider, CJ Radoux, A Hercules, D Ochoa, I Dunham, LP Zalmas, ...
Nature reviews Drug discovery 20 (10), 789-797, 2021
1752021
The in silico world of virtual libraries
AR Leach, MM Hann
Drug discovery today 5 (8), 326-336, 2000
1722000
Stabilization of protein-protein interactions in drug discovery
SA Andrei, E Sijbesma, M Hann, J Davis, G O’Mahony, MWD Perry, ...
Expert opinion on drug discovery 12 (9), 925-940, 2017
1682017
Chemoinformatics—a new name for an old problem?
M Hann, R Green
Current Opinion in Chemical Biology 3 (4), 379-383, 1999
1501999
Behavior of cholesterol and its effect on head group and chain conformations in lipid bilayers: a molecular dynamics study
AJ Robinson, WG Richards, PJ Thomas, MM Hann
Biophysical journal 68 (1), 164-170, 1995
1491995
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
PF Chan, V Srikannathasan, J Huang, H Cui, AP Fosberry, M Gu, ...
Nature communications 6 (1), 10048, 2015
1362015
Implementation of a system for reagent selection and library enumeration, profiling, and design
AR Leach, J Bradshaw, DVS Green, MM Hann, JJ Delany
Journal of chemical information and computer sciences 39 (6), 1161-1172, 1999
1101999
The synthesis and antiviral activity of 4-fluoro-1-β-D-ribofuranosyl-1H-pyrazole-3-carboxamide
R Storer, CJ Ashton, AD Baxter, MM Hann, CLP Marr, AM Mason, CL Mo, ...
Nucleosides, Nucleotides & Nucleic Acids 18 (2), 203-216, 1999
1101999
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