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céline Philippe
céline Philippe
INSERM U1242
Dirección de correo verificada de univ-rennes.fr
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Translational regulations in response to endoplasmic reticulum stress in cancers
M Jaud, C Philippe, D Di Bella, W Tang, S Pyronnet, H Laurell, ...
Cells 9 (3), 540, 2020
652020
PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress
C Philippe, A Dubrac, C Quelen, A Desquesnes, L Van Den Berghe, ...
Science signaling 9 (426), ra44-ra44, 2016
472016
ER stress and unfolded protein response in leukemia: friend, foe, or both?
K Féral, M Jaud, C Philippe, D Di Bella, S Pyronnet, K Rouault-Pierre, ...
Biomolecules 11 (2), 199, 2021
462021
Key contribution of eIF4H-mediated translational control in tumor promotion
C Vaysse, C Philippe, Y Martineau, C Quelen, C Hieblot, C Renaud, ...
Oncotarget 6 (37), 39924, 2015
452015
Hypoxia and ER stress promote Staufen1 expression through an alternative translation mechanism
F Bonnet-Magnaval, C Philippe, L Van Den Berghe, H Prats, C Touriol, ...
Biochemical and biophysical research communications 479 (2), 365-371, 2016
292016
The PERK branch of the unfolded protein response promotes DLL4 expression by activating an alternative translation mechanism
M Jaud, C Philippe, L Van Den Berghe, C Ségura, L Mazzolini, ...
Cancers 11 (2), 142, 2019
192019
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, KM Rattigan, ...
Nature Communications 14 (1), 2132, 2023
172023
The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes
N Berastegui, M Ainciburu, JP Romero, P Garcia-Olloqui, ...
Nature Communications 13 (1), 7619, 2022
152022
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia
SA Mian, C Philippe, E Maniati, P Protopapa, T Bergot, M Piganeau, ...
Science translational medicine 15 (685), eabn5135, 2023
122023
Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment
H Armes, F Bewicke‐Copley, A Rio‐Machin, D Di Bella, C Philippe, ...
British Journal of Haematology 199 (5), 754-764, 2022
82022
Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy
C Philippe, M Jaud, K Féral, A Gay, L Van Den Berghe, M Farce, ...
Leukemia 38 (8), 1764-1776, 2024
72024
Transcriptional regulation of HSCs in aging and MDS reveals DDIT3 as a potential driver of transformation
N Berastegui, M Ainciburu, JP Romero, A Alfonso-Pierola, C Philippe, ...
bioRxiv, 2021.09. 08.459384, 2021
42021
Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation
V Dembitz, H Lawson, R Burt, S Natani, C Philippe, SC James, S Atkinson, ...
Leukemia 38 (11), 2395-2409, 2024
22024
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
IY Choi, JP Ling, J Zhang, E Helmenstine, W Walter, P Tsakiroglou, ...
Blood Advances 8 (15), 3961-3971, 2024
12024
SCD inhibition preferentially eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy
V Dembitz, H Lawson, R Burt, C Philippe, SC James, S Atkinson, J Durko, ...
bioRxiv, 2023.08. 02.551656, 2023
12023
Inhibition of Stearoyl-CoA Desaturase Has Anti-Leukemic Properties in Acute Myeloid Leukemia
V Dembitz, H Lawson, C Philippe, RJ Burt, S James, ASM Magee, ...
Blood 140 (Supplement 1), 3058-3060, 2022
12022
Mannose Metabolism Is a Metabolic Vulnerability Unveiled By Standard and Novel Therapies in Acute Myeloid Leukemia
K Woodley, LS Dillingh, G Giotopoulos, P Madrigal, K Tzelepis, C Philippe, ...
Blood 138, 508, 2021
12021
A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo
C Philippe, S Burke, K Rouault-Pierre
Journal of Visualized Experiments (JoVE), e67123, 2025
2025
Proximity Interactome analyses unveil novel regulators of IRE1α canonical signaling
S Le Goupil, C Philippe, H Laprade, M Lode, R Boniface, ...
bioRxiv, 2024.10. 27.620453, 2024
2024
The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts
W Dalton, I Choi, J Ling, J Zhang, E Helmenstine, W Walter, R Bergman, ...
2023
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