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Tommy Weiss-Sadan, Ph.D.
Tommy Weiss-Sadan, Ph.D.
Harvard Medical School and Massachusetts General Hospital
Dirección de correo verificada de mgh.harvard.edu
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The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
M Mahameed, T Wilhelm, O Darawshi, A Obiedat, WS Tommy, C Chintha, ...
Cell death & disease 10 (4), 300, 2019
862019
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
J Zhang, CM Simpson, J Berner, HB Chong, J Fang, Z Ordulu, ...
Cell 186 (11), 2361-2379. e25, 2023
812023
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
T Weiss-Sadan, M Ge, M Hayashi, M Gohar, CH Yao, A de Groot, S Harry, ...
Cell metabolism 35 (3), 487-503. e7, 2023
782023
Characterizing cathepsin activity and macrophage subtypes in excised human carotid plaques
I Abd-Elrahman, K Meir, H Kosuge, Y Ben-Nun, T Weiss Sadan, ...
Stroke 47 (4), 1101-1108, 2016
692016
CT imaging of enzymatic activity in cancer using covalent probes reveal a size-dependent pattern
D Tsvirkun, Y Ben-Nun, E Merquiol, I Zlotver, K Meir, T Weiss-Sadan, ...
Journal of the American Chemical Society 140 (38), 12010-12020, 2018
632018
A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
Y Shaulov-Rotem, E Merquiol, T Weiss-Sadan, O Moshel, S Salpeter, ...
Chemical Science 7 (2), 1322-1337, 2016
512016
Cysteine proteases in atherosclerosis
T Weiss‐Sadan, I Gotsman, G Blum
The FEBS Journal 284 (10), 1455-1472, 2017
472017
Cathepsin inhibition modulates metabolism and polarization of tumor-associated macrophages
D Oelschlaegel, T Weiss Sadan, S Salpeter, S Krug, G Blum, W Schmitz, ...
Cancers 12 (9), 2579, 2020
452020
Cathepsin activity-based probes and inhibitor for preclinical atherosclerosis imaging and macrophage depletion
I Abd-Elrahman, H Kosuge, T Wises Sadan, Y Ben-Nun, K Meir, ...
PLoS One 11 (8), e0160522, 2016
422016
Relative genomic stability of adipose tissue derived mesenchymal stem cells: analysis of ploidy, H19 long non-coding RNA and p53 activity
O Ravid, O Shoshani, M Sela, A Weinstock, TW Sadan, E Gur, D Zipori, ...
Stem cell research & therapy 5, 1-11, 2014
312014
A theranostic cathepsin activity-based probe for noninvasive intervention in cardiovascular diseases
T Weiss-Sadan, Y Ben-Nun, D Maimoun, E Merquiol, I Abd-Elrahman, ...
Theranostics 9 (20), 5731, 2019
262019
Cathepsins drive anti-inflammatory activity by regulating autophagy and mitochondrial dynamics in macrophage foam cells
T Weiss-Sadan, D Maimoun, D Oelschlagel, F Kaschani, D Misiak, ...
Cell Physiol Biochem 53 (3), 550-72, 2019
252019
Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation [S]
T Weiss-Sadan, G Itzhak, F Kaschani, Z Yu, M Mahameed, A Anaki, ...
Molecular & Cellular Proteomics 18 (7), 1330-1344, 2019
102019
Improved Cathepsin Probes for Sensitive Molecular Imaging
Y Yitzhak, H Gaikwad, T Weiss-Sadan, E Merquiol, B Turk, G Blum
Molecules 27 (3), 842, 2022
32022
Cysteine Proteases Cathepsins: From Basic Science to Translational Applications
T Weiss-Sadan
PQDT-Global, 2019
2019
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Artículos 1–15