Nature's inventory of halogenation catalysts: oxidative strategies predominate FH Vaillancourt, E Yeh, DA Vosburg, S Garneau-Tsodikova, CT Walsh Chemical reviews 106 (8), 3364-3378, 2006 | 636 | 2006 |
The ins and outs of ring-cleaving dioxygenases FH Vaillancourt, JT Bolin, LD Eltis Critical Reviews in Biochemistry and Molecular Biology 41 (4), 241-267, 2006 | 507 | 2006 |
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis LC Blasiak, FH Vaillancourt, CT Walsh, CL Drennan Nature 440 (7082), 368-371, 2006 | 446 | 2006 |
SyrB2 in syringomycin E biosynthesis is a nonheme FeII α-ketoglutarate-and O2-dependent halogenase FH Vaillancourt, J Yin, CT Walsh Proceedings of the National Academy of Sciences 102 (29), 10111-10116, 2005 | 387 | 2005 |
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis FH Vaillancourt, E Yeh, DA Vosburg, SE O'Connor, CT Walsh Nature 436 (7054), 1191-1194, 2005 | 360 | 2005 |
Substrate-triggered formation and remarkable stability of the C− H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2 ML Matthews, CM Krest, EW Barr, FH Vaillancourt, CT Walsh, MT Green, ... Biochemistry 48 (20), 4331-4343, 2009 | 266 | 2009 |
Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis DP Galonić, FH Vaillancourt, CT Walsh Journal of the American Chemical Society 128 (12), 3900-3901, 2006 | 216 | 2006 |
Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains CJ Balibar, FH Vaillancourt, CT Walsh Chemistry & biology 12 (11), 1189-1200, 2005 | 195 | 2005 |
Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication FH Vaillancourt, L Pilote, M Cartier, J Lippens, M Liuzzi, RC Bethell, ... Virology 387 (1), 5-10, 2009 | 172 | 2009 |
The mechanism-based inactivation of 2, 3-dihydroxybiphenyl 1, 2-dioxygenase by catecholic substrates FH Vaillancourt, G Labbé, NM Drouin, PD Fortin, LD Eltis Journal of Biological Chemistry 277 (3), 2019-2027, 2002 | 153 | 2002 |
Definitive evidence for monoanionic binding of 2, 3-dihydroxybiphenyl to 2, 3-dihydroxybiphenyl 1, 2-dioxygenase from UV resonance Raman spectroscopy, UV/Vis absorption … FH Vaillancourt, CJ Barbosa, TG Spiro, JT Bolin, MW Blades, RFB Turner, ... Journal of the American Chemical Society 124 (11), 2485-2496, 2002 | 152 | 2002 |
Identification and analysis of a bottleneck in PCB biodegradation S Dai, FH Vaillancourt, H Maaroufi, NM Drouin, DB Neau, V Snieckus, ... nature structural biology 9 (12), 934-939, 2002 | 132 | 2002 |
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer X Puyang, C Furman, GZ Zheng, ZJ Wu, D Banka, K Aithal, S Agoulnik, ... Cancer discovery 8 (9), 1176-1193, 2018 | 108 | 2018 |
Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1, 2-dioxygenase by t-butanol FH Vaillancourt, S Han, PD Fortin, JT Bolin, LD Eltis Journal of Biological Chemistry 273 (52), 34887-34895, 1998 | 108 | 1998 |
Enzymatic generation of the antimetabolite γ, γ-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete M Ueki, DP Galonić, FH Vaillancourt, S Garneau-Tsodikova, E Yeh, ... Chemistry & biology 13 (11), 1183-1191, 2006 | 102 | 2006 |
Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo C Spickler, J Lippens, MK Laberge, S Desmeules, É Bellavance, ... Antimicrobial agents and chemotherapy 57 (7), 3358-3368, 2013 | 91 | 2013 |
Evaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug target FH Vaillancourt, M Brault, L Pilote, N Uyttersprot, ET Gaillard, JH Stoltz, ... Journal of virology 86 (21), 11595-11607, 2012 | 71 | 2012 |
Dichlorination and bromination of a threonyl-S-carrier protein by the non-heme Fe (II) halogenase SyrB2. FH Vaillancourt, DA Vosburg, CT Walsh Chembiochem: a European Journal of Chemical Biology 7 (5), 748-752, 2006 | 69 | 2006 |
Spectroscopic and Electronic Structure Studies of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase: O2 Reactivity of the Non-Heme Ferrous Site in Extradiol Dioxygenases MI Davis, EC Wasinger, A Decker, MYM Pau, FH Vaillancourt, JT Bolin, ... Journal of the American Chemical Society 125 (37), 11214-11227, 2003 | 67 | 2003 |
Characterization of extradiol dioxygenases from a polychlorinated biphenyl-degrading strain that possess higher specificities for chlorinated metabolites FH Vaillancourt, MA Haro, NM Drouin, Z Karim, H Maaroufi, LD Eltis Journal of bacteriology 185 (4), 1253-1260, 2003 | 54 | 2003 |