Inflammasomes: mechanism of assembly, regulation and signalling P Broz, VM Dixit Nature Reviews Immunology 16 (7), 407-420, 2016 | 3297 | 2016 |
The gasdermins, a protein family executing cell death and inflammation P Broz, P Pelegrín, F Shao Nature Reviews Immunology 20 (3), 143-157, 2020 | 1245 | 2020 |
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death L Sborgi, S Rühl, E Mulvihill, J Pipercevic, R Heilig, H Stahlberg, ... The EMBO journal 35 (16), 1766-1778, 2016 | 1121 | 2016 |
Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing P Broz, J von Moltke, JW Jones, RE Vance, DM Monack Cell host & microbe 8 (6), 471-483, 2010 | 726 | 2010 |
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella P Broz, K Newton, M Lamkanfi, S Mariathasan, VM Dixit, DM Monack Journal of Experimental Medicine 207 (8), 1745-1755, 2010 | 679 | 2010 |
Newly described pattern recognition receptors team up against intracellular pathogens P Broz, DM Monack Nature Reviews Immunology 13 (8), 551-565, 2013 | 625 | 2013 |
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation S Rühl, K Shkarina, B Demarco, R Heilig, JC Santos, P Broz Science 362 (6417), 956-960, 2018 | 624 | 2018 |
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 P Broz, T Ruby, K Belhocine, DM Bouley, N Kayagaki, VM Dixit, ... Nature 490 (7419), 288-291, 2012 | 614 | 2012 |
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis JW Jones, N Kayagaki, P Broz, T Henry, K Newton, K O'Rourke, S Chan, ... Proceedings of the National Academy of Sciences 107 (21), 9771-9776, 2010 | 592 | 2010 |
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps KW Chen, M Monteleone, D Boucher, G Sollberger, D Ramnath, ... Science immunology 3 (26), eaar6676, 2018 | 558 | 2018 |
Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K+ efflux S Rühl, P Broz European journal of immunology 45 (10), 2927-2936, 2015 | 550 | 2015 |
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases E Meunier, MS Dick, RF Dreier, N Schürmann, DK Broz, S Warming, ... Nature 509 (7500), 366-370, 2014 | 515 | 2014 |
K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria CJ Groß, R Mishra, KS Schneider, G Médard, J Wettmarshausen, ... Immunity 45 (4), 761-773, 2016 | 488 | 2016 |
The V-Antigen of Yersinia Forms a Distinct Structure at the Tip of Injectisome Needles CA Mueller, P Broz, SA Müller, P Ringler, F Erne-Brand, I Sorg, M Kuhn, ... Science 310 (5748), 674-676, 2005 | 450 | 2005 |
ASC filament formation serves as a signal amplification mechanism for inflammasomes MS Dick, L Sborgi, S Rühl, S Hiller, P Broz Nature communications 7 (1), 1-13, 2016 | 399 | 2016 |
The Gasdermin‐D pore acts as a conduit for IL‐1β secretion in mice R Heilig, MS Dick, L Sborgi, E Meunier, S Hiller, P Broz European journal of immunology 48 (4), 584-592, 2018 | 393 | 2018 |
The needle length of bacterial injectisomes is determined by a molecular ruler L Journet, C Agrain, P Broz, GR Cornelis Science 302 (5651), 1757-1760, 2003 | 387 | 2003 |
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida E Meunier, P Wallet, RF Dreier, S Costanzo, L Anton, S Rühl, ... Nature immunology 16 (5), 476-484, 2015 | 371 | 2015 |
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly KW Chen, B Demarco, R Heilig, K Shkarina, A Boettcher, CJ Farady, ... The EMBO journal 38 (10), e101638, 2019 | 369 | 2019 |
Molecular mechanisms of inflammasome activation during microbial infections P Broz, DM Monack Immunological reviews 243 (1), 174-190, 2011 | 327 | 2011 |