Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders PM Gosavi, KC Ngan, MJR Yeo, C Su, J Li, NZ Lue, SM Hoenig, BB Liau ACS Central Science 8 (4), 417-429, 2022 | 46 | 2022 |
Base editor scanning charts the DNMT3A activity landscape NZ Lue, EM Garcia, KC Ngan, C Lee, JG Doench, BB Liau Nature Chemical Biology 19 (2), 176-186, 2023 | 36 | 2023 |
Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery AP Siegenfeld, SA Roseman, H Roh, NZ Lue, CC Wagen, E Zhou, ... Nature Communications 13 (1), 4199, 2022 | 25 | 2022 |
Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery KCH Ngan, SM Hoenig, HS Kwok, NZ Lue, PM Gosavi, DA Tanner, ... Elife 12, e80640, 2023 | 16 | 2023 |
Base editor screens for in situ mutational scanning at scale NZ Lue, BB Liau Molecular Cell 83 (13), 2167-2187, 2023 | 15 | 2023 |
Base editor scanning reveals activating mutations of DNMT3A EM Garcia, NZ Lue, JK Liang, WK Lieberman, DD Hwang, JC Woods, ... ACS chemical biology 18 (9), 2030-2038, 2023 | 6 | 2023 |
CRISPR‐Suppressor scanning for systematic discovery of drug‐resistance mutations KC Ngan, NZ Lue, C Lee, BB Liau Current protocols 2 (12), e614, 2022 | 5 | 2022 |
DNA methylation insulates genic regions from CTCF loops near nuclear speckles SA Roseman, AP Siegenfeld, C Lee, NZ Lue, AL Waterbury, BB Liau bioRxiv, 2023.07. 26.550645, 2023 | 2 | 2023 |
Structural insights into transcriptional regulation by the helicase RECQL5 AJ Florez Ariza, NZ Lue, P Grob, B Kaeser, J Fang, SA Kassube, ... bioRxiv, 2025.01. 29.634372, 2025 | | 2025 |
Probing regulatory mechanisms of the de novo DNA methyltransferase DNMT3A EM Garcia, NZ Lue, K Rivera, M Virshup, JK Liang, DD Hwang, SA Carr, ... Biophysical Journal 122 (3), 352a, 2023 | | 2023 |
Integrating functional genomics and biochemistry to interrogate DNMT3A sequence–function NZB Lue Harvard University, 2023 | | 2023 |