Michael Seiler

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Silvia BuonamiciConsultant Third Rock VenturesDirección de correo verificada de thirdrockventures.com
Anant Akash AgrawalRemix TherapeuticsDirección de correo verificada de remixtx.com
Shridar GanesanProfessor of Medicine, Rutgers Cancer Institute of New JerseyDirección de correo verificada de cinj.rutgers.edu
Anupama ReddyData Scientist | Co-founder @ Vindhya Data ScienceDirección de correo verificada de vindhyadatascience.com
James PalacinoHead of Biology, Orum TherapeuticsDirección de correo verificada de orumrx.com
Frederic VaillancourtSVP, Head of Early Research, Remix TherapeuticsDirección de correo verificada de remixtx.com
Benjamin L. EbertDana-Farber Cancer InstituteDirección de correo verificada de dfci.harvard.edu
Peter Fekkes54gene, HotSpot Therapeutics, H3 Biomedicine, Novartis, UC San Diego, University of GroningenDirección de correo verificada de 54gene.com
George VassiliouProfessor of Haematological Medicine, University of Cambridge & Cambridge Stem Cell InstituteDirección de correo verificada de sanger.ac.uk
Shouyong PengData Scientist, H3 BiomedicineDirección de correo verificada de h3biomedicine.com
Annalisa MupoScientific Programme ManagerDirección de correo verificada de altoslabs.com
Chia-Ling HuangNovartis Institutes of Biomedical ResearchDirección de correo verificada de bu.edu
Zuzana TothovaDana-Farber Cancer Institute, Broad InstituteDirección de correo verificada de broadinstitute.org
Peter SmithUniversity of SunderlandDirección de correo verificada de sunderland.ac.uk
Jinesh GheeyaThe Ohio State UniversityDirección de correo verificada de osumc.edu
Bryan M. DunyakRemix TherapeuticsDirección de correo verificada de remixtx.com
Katsuhiro TogamiMedical oncology, Dana-Farbar Cancer InstitutionDirección de correo verificada de dfci.harvard.edu
Andrew A. Lane, MD, PhDDana-Farber Cancer InstituteDirección de correo verificada de dfci.harvard.edu
Stanley Chun-Wei LeeFred Hutchinson Cancer CenterDirección de correo verificada de fredhutch.org
Jesper L.V. MaagRemix TherapeuticsDirección de correo verificada de remixtx.com

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Michael Seiler

Remix Therapeutics

Dirección de correo verificada de remixtx.com

Oncology RNA Biology


Título Ordenar por citas Ordenar por año Ordenar por título	Citado por Citado por	Año
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018	514	2018
Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ... Cell reports 13 (5), 1033-1045, 2015	490	2015
Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... Cell reports 23 (1), 282-296. e4, 2018	422	2018
Physiologic expression of Sf3b1K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to therapeutic spliceosome modulation EA Obeng, RJ Chappell, M Seiler, MC Chen, DR Campagna, PJ Schmidt, ... Cancer cell 30 (3), 404-417, 2016	406	2016
Molecular stratification of clear cell renal cell carcinoma by consensus clustering reveals distinct subtypes and survival patterns AR Brannon, A Reddy, M Seiler, A Arreola, DT Moore, RS Pruthi, ... Genes & cancer 1 (2), 152-163, 2010	364	2010
Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma H Liu, AR Brannon, AR Reddy, G Alexe, MW Seiler, A Arreola, JH Oza, ... BMC systems biology 4, 1-17, 2010	324	2010
Synthetic lethal and convergent biological effects of cancer-associated spliceosomal gene mutations SCW Lee, K North, E Kim, E Jang, E Obeng, SX Lu, B Liu, D Inoue, ... Cancer cell 34 (2), 225-241. e8, 2018	231	2018
Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia L Wang, AN Brooks, J Fan, Y Wan, R Gambe, S Li, S Hergert, S Yin, ... Cancer cell 30 (5), 750-763, 2016	229	2016
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex T Teng, JHC Tsai, X Puyang, M Seiler, S Peng, S Prajapati, D Aird, ... Nature communications 8 (1), 15522, 2017	153	2017
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ... Leukemia 31 (3), 720-727, 2017	147	2017
Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS T Yamauchi, T Masuda, MC Canver, M Seiler, Y Semba, M Shboul, ... Cancer cell 33 (3), 386-400. e5, 2018	140	2018
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer M Korpal, X Puyang, Z Jeremy Wu, R Seiler, C Furman, HZ Oo, M Seiler, ... Nature communications 8 (1), 103, 2017	137	2017
Identifying microRNA/mRNA dysregulations in ovarian cancer GD Miles, M Seiler, L Rodriguez, G Rajagopal, G Bhanot BMC research notes 5, 1-10, 2012	132	2012
ConsensusCluster: a software tool for unsupervised cluster discovery in numerical data M Seiler, CC Huang, S Szalma, G Bhanot OMICS A Journal of Integrative Biology 14 (1), 109-113, 2010	107	2010
Lactase persistence and lipid pathway selection in the Maasai K Wagh, A Bhatia, G Alexe, A Reddy, V Ravikumar, M Seiler, M Boemo, ... Public Library of Science 7 (9), e44751, 2012	75	2012
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis K Togami, SS Chung, V Madan, CAG Booth, CM Kenyon, L Cabal-Hierro, ... Cancer discovery 12 (2), 522-541, 2022	73	2022
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 K Tzelepis, E De Braekeleer, D Aspris, I Barbieri, MS Vijayabaskar, ... Nature communications 9 (1), 5378, 2018	72	2018
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators D Aird, T Teng, CL Huang, E Pazolli, D Banka, K Cheung-Ong, C Eifert, ... Nature communications 10 (1), 137, 2019	71	2019
Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies E Ten Hacken, R Valentin, FFD Regis, J Sun, S Yin, L Werner, J Deng, ... JCI insight 3 (19), 2018	57	2018
Towards improved cancer diagnosis and prognosis using analysis of gene expression data and computer aided imaging G Alexe, J Monaco, S Doyle, A Basavanhally, A Reddy, M Seiler, ... Experimental Biology and Medicine 234 (8), 860-879, 2009	52	2009

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