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Robert Monsen
Robert Monsen
Assistant Professor of Medicine, UofL
Dirección de correo verificada de louisville.edu
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The hTERT core promoter forms three parallel G-quadruplexes
RC Monsen, L DeLeeuw, WL Dean, RD Gray, TM Sabo, S Chakravarthy, ...
Nucleic acids research 48 (10), 5720-5734, 2020
812020
G-quadruplex virtual drug screening: A review
RC Monsen, JO Trent
Biochimie 152, 134-148, 2018
582018
G-quadruplex DNA: a longer story
RC Monsen, JO Trent, JB Chaires
Accounts of chemical research 55 (22), 3242-3252, 2022
452022
The solution structures of higher-order human telomere G-quadruplex multimers
RC Monsen, S Chakravarthy, WL Dean, JB Chaires, JO Trent
Nucleic acids research 49 (3), 1749-1768, 2021
402021
Human POT1 unfolds G-quadruplexes by conformational selection
JB Chaires, RD Gray, WL Dean, R Monsen, LW DeLeeuw, V Stribinskis, ...
Nucleic Acids Research 48 (9), 4976-4991, 2020
382020
Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences
RC Monsen, LW DeLeeuw, WL Dean, RD Gray, S Chakravarthy, ...
Nucleic Acids Research 50 (7), 4127-4147, 2022
362022
Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 Å resolution with cryo-EM
RC Monsen, EYD Chua, JB Hopkins, JB Chaires, JO Trent
Nucleic acids research 51 (4), 1943-1959, 2023
182023
Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex
RC Monsen, JM Maguire, LW DeLeeuw, JB Chaires, JO Trent
PloS one 17 (6), e0270165, 2022
152022
POT1 stability and binding measured by fluorescence thermal shift assays
LW DeLeeuw, RC Monsen, V Petrauskas, RD Gray, L Baranauskiene, ...
Plos one 16 (3), e0245675, 2021
122021
Higher-order G-quadruplexes in promoters are untapped drug targets
RC Monsen
Frontiers in Chemistry 11, 1211512, 2023
82023
Putting a new spin of G-Quadruplex structure and binding by analytical ultracentrifugation
WL Dean, RD Gray, L DeLeeuw, RC Monsen, JB Chaires
G-Quadruplex Nucleic Acids: Methods and Protocols, 87-103, 2019
62019
Strategy for modeling higher-order G-quadruplex structures recalcitrant to NMR determination
TM Sabo, JO Trent, JB Chaires, RC Monsen
Methods 230, 9-20, 2024
12024
Early events in G-quadruplex folding captured by time-resolved small-angle X-ray scattering
RC Monsen, TM Sabo, R Gray, JB Hopkins, JB Chaires
Nucleic Acids Research 53 (3), gkaf043, 2025
2025
Interaction of N-methylmesoporphyrin IX with a hybrid left-/right-handed G-quadruplex motif from the promoter of the SLC2A1 gene
P Seth, E Xing, AD Hendrickson, K Li, R Monsen, JB Chaires, S Neidle, ...
Nucleic Acids Research 53 (2), gkae1208, 2025
2025
Abstract 1789 Structural Characterization and Targeting of Higher-order DNA G-quadruplexes
R Monsen, L DeLeeuw, J Chaires, J Trent
Journal of Biological Chemistry 300 (3), 2024
2024
Structural Characterization and Targeting of Higher-Order Promoter G-Quadruplexes
RC Monsen, LW DeLeeuw, WL Dean, RD Gray, S Chakravarthy, ...
Acta Cryst 79, a216, 2023
2023
Compound 5-6, a CBL E3 ubiquitin ligase antagonist, enhances EGFR-mediated corneal epithelial cell biology
BP Ceresa, BLM Crotchett, A Halder, R Monsen, L DeLeeuw, ...
Investigative Ophthalmology & Visual Science 64 (8), 3151-3151, 2023
2023
Structure of a duplex-embedded G-quadruplex system resolved to 7.4 Å resolution by cryo-EM
R Monsen, E Chua, J Hopkins, J Chaires, J Trent
Research Square, 2022
2022
Structure and dynamics of a duplex-embedded G-quadruplex system resolved to 7.4 Å resolution by cryo-EM and SAXS
R Monsen, E Chua, J Hopkins, J Chaires, J Trent
2022
Structural characterization and selective drug targeting of higher-order DNA G-quadruplex systems.
RC Monsen
2020
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Artículos 1–20