| Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. P Westermark, C Wernstedt, E Wilander, DW Hayden, TD O'Brien, ... Proceedings of the National Academy of Sciences 84 (11), 3881-3885, 1987 | 1212 | 1987 |
| Feline renal failure: questions, answers, questions. JP Lulich, TD O'Brien, CA Osborne, DJ Polzin | 409 | 1992 |
| Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. P Westermark, C Wernstedt, TD O'Brien, DW Hayden, KH Johnson The American journal of pathology 127 (3), 414, 1987 | 364 | 1987 |
| Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus KH Johnson, TD O'Brien, C Betsholtz, P Westermark New England Journal of Medicine 321 (8), 513-518, 1989 | 309 | 1989 |
| Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. KH Johnson, TD O'brien, DW Hayden, K Jordan, HK Ghobrial, ... The American journal of pathology 130 (1), 1, 1988 | 262 | 1988 |
| Evidence for proteotoxicity in β cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway T Gurlo, S Ryazantsev, C Huang, MW Yeh, HA Reber, OJ Hines, ... The American journal of pathology 176 (2), 861-869, 2010 | 261 | 2010 |
| Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis M Couce, TD O'Brien, A Moran, PC Roche, PC Butler The Journal of Clinical Endocrinology & Metabolism 81 (3), 1267-1272, 1996 | 177 | 1996 |
| Feline models of type 2 diabetes mellitus MS Henson, TD O'Brien ILAR journal 47 (3), 234-242, 2006 | 165 | 2006 |
| Impaired glucose tolerance is associated with increased islet amyloid polypeptide (IAPP) immunoreactivity in pancreatic beta cells. KH Johnson, TD O'Brien, K Jordan, P Westermark The American journal of pathology 135 (2), 245, 1989 | 158 | 1989 |
| Islet amyloid polypeptide—a novel controversy in diabetes research P Westermark, KH Johnson, TD O'Brien, C Betsholtz Diabetologia 35, 297-303, 1992 | 150 | 1992 |
| Rapid induction of cerebral organoids from human induced pluripotent stem cells using a chemically defined hydrogel and defined cell culture medium. OBTD Lindborg BA, Brekke JH, Ulrich C, Haider K, Subramaaniam S, Venhuizen S ... Stem Cells Translational Medicine, 2016 | 145 | 2016 |
| Reversal of new-onset diabetes through modulating inflammation and stimulating β-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor L Tian, J Gao, J Hao, Y Zhang, H Yi, TD O'Brien, R Sorenson, J Luo, ... Endocrinology 151 (7), 3049-3060, 2010 | 145 | 2010 |
| Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus TD O'Brien, PC Butler, P Westermark, KH Johnson Veterinary pathology 30 (4), 317-332, 1993 | 138 | 1993 |
| Pathogenesis of feline diabetes mellitus TD O'Brien Molecular and cellular endocrinology 197 (1-2), 213-219, 2002 | 137 | 2002 |
| Molecular profiling reveals prognostically significant subtypes of canine lymphoma AM Frantz, AL Sarver, D Ito, TL Phang, A Karimpour-Fard, MC Scott, ... Veterinary pathology 50 (4), 693-703, 2013 | 136 | 2013 |
| Islet amyloid polypeptide and insulin secretion from isolated perfused pancreas of fed, fasted, glucose-treated, and dexamethasone-treated rats TD O'Brien, P Westermark, KH Johnson Diabetes 40 (12), 1701-1706, 1991 | 135 | 1991 |
| Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation C Betsholtz, L Christmanson, U Engström, F Rorsman, K Jordan, ... Diabetes 39 (1), 118-122, 1990 | 132 | 1990 |
| Multipotent adult progenitor cells from swine bone marrow L Zeng, E Rahrmann, Q Hu, T Lund, L Sandquist, M Felten, TD O'Brien, ... Stem cells 24 (11), 2355-2366, 2006 | 125 | 2006 |
| Islet amyloid polypeptide in human insulinomas: evidence for intracellular amyloidogenesis TD O'Brien, AE Butler, PC Roche, KH Johnson, PC Butler Diabetes 43 (2), 329-336, 1994 | 125 | 1994 |
| Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and β-cell dysfunction M Couce, LA Kane, TD O'Brien, J Charlesworth, W Soeller, J McNeish, ... Diabetes 45 (8), 1094-1101, 1996 | 124 | 1996 |
